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Total 61 results found since Jan 2013.

Alpha-gal syndrome: a review for the dermatologist.
Alpha-gal syndrome (AGS) is an allergy to “red” meat and other mammalian products due to immunoglobulin E (IgE) antibodies against the sugar moiety galactose-alpha-1,3-galactose (alpha-gal), which is acquired following tick bites. Clinically, AGS presents with urticaria, abdominal pain, nausea, and occasionally anaphylaxis, and has wide inter- and intra-personal variability. Because symptom onset is generally delayed by two to six hours after meat consumption, AGS can be easily confused with other causes of urticaria and anaphylaxis, such as chronic spontaneous urticaria (CSU) and mast cell activation syndrome (MCAS).
Source: Journal of the American Academy of Dermatology - May 5, 2023 Category: Dermatology Authors: Soumya Reddy, Lauren Yi, Bridget Shields, Thomas Platts-Mills, Jeffrey Wilson, R. Hal Flowers Source Type: research

Alpha-gal syndrome: A review for the dermatologist
Alpha-gal syndrome (AGS) is an allergy to “red meat” and other mammalian products due to immunoglobulin E (IgE) antibodies against the sugar moiety galactose-alpha-1,3-galactose (alpha-gal), which is acquired following tick bites. Clinically, AGS presents with urticaria, abdominal pain, nausea, and occasionally anaphylaxis, and has wide inter- and intra-personal variability. Because symptom onset is generally delayed by 2 to 6 hours after meat consumption, AGS can be easily confused with other causes of urticaria and anaphylaxis, such as chronic spontaneous urticaria (CSU) and mast cell activation syndrome (MCAS).
Source: Journal of the American Academy of Dermatology - May 5, 2023 Category: Dermatology Authors: Soumya Reddy, Lauren Yi, Bridget Shields, Thomas Platts-Mills, Jeffrey Wilson, R. Hal Flowers Tags: Clinical review Source Type: research

Alpha-gal Syndrome Misdiagnosed As Chronic Spontaneous Urticaria Alpha-gal Syndrome Misdiagnosed As Chronic Spontaneous Urticaria
While alpha-gal syndrome usually is found in adults, this case illustrates that children can also present with this potentially life-threatening allergy to red meat.Journal of Medical Case Reports
Source: Medscape Allergy Headlines - April 14, 2023 Category: Allergy & Immunology Tags: Family Medicine/Primary Care Journal Article Source Type: news

AGA Clinical Practice Update on Alpha-Gal Syndrome for the GI Clinician: Commentary
Alpha-gal syndrome causes an IgE-mediated reaction hours after eating beef, pork, other mammalian meat, or mammalian-derived products.1 Although the allergy was first described in patients with anaphylaxis and urticaria, gastrointestinal (GI) alpha-gal is a phenotype that increasingly is recognized and manifests with GI symptoms such as abdominal pain, diarrhea, nausea, and vomiting without predominant skin, respiratory, or circulatory symptoms.2 –9 It is important for gastroenterologists to be aware of this condition and to be capable of diagnosing and treating it in a timely manner.
Source: Clinical Gastroenterology and Hepatology - February 24, 2023 Category: Gastroenterology Authors: Sarah K. McGill, Jana G. Hashash, Thomas A. Platts-Mills Tags: Clinical Practice Update Source Type: research

Alpha-gal syndrome initially misdiagnosed as chronic spontaneous urticaria in a pediatric patient: a case report and review  of the literature
ConclusionA detailed clinical history led to the diagnosis of alpha-gal syndrome. Although alpha-gal syndrome is typically seen in adults, our case illustrates that children can also present with this potentially life-threatening allergy. Since alpha-gal syndrome is rare in Europe, the disease is not well known and often overlooked for several years, especially in children.
Source: Journal of Medical Case Reports - January 8, 2023 Category: General Medicine Source Type: research

Newly Recognized α-Gal Syndrome in the Upper Midwestern United States
α-Gal syndrome is a recently recognized entity in which allergy to mammalian meat may be acquired by exposure to the disaccharide galactose-α-1,3-galactose (α-gal) antigen through the saliva of the Lone Star tick. Subsequent exposure to the antigen in meat may result in the delayed presentation ( 3 to 6 hours after ingestion) of systemic hypersensitivity reactions (eg, urticaria, angioedema), gastrointestinal symptoms, or life-threatening anaphylaxis.1,2 Anaphylaxis is potentially fatal, and identifying the cause is critical.
Source: Mayo Clinic Proceedings - September 1, 2022 Category: Internal Medicine Authors: Gina R. Chacon Osorio, Raj Palraj, Sheryl van Nunen, Michael J. White Tags: Letter to the editor Source Type: research

M236 alpha gal syndrome: an evolving red meat allergy
Alpha gal syndrome (AGS) is a tick-borne disease, induced by an IgE antibody reaction against the carbohydrate galactose-alpha-1, 3-galactose, found primarily in beef, pork or lamb. Symptoms range from hives to anaphylaxis, with the distinctive feature being delayed symptom onset starting 3 to 6 hours after eating meat. Growing evidence suggests AGS is associated with bites from the lone star tick (Amblyomma Americanum).
Source: Annals of Allergy, Asthma and Immunology - November 1, 2021 Category: Allergy & Immunology Authors: K. Lacy, J. Gillen-Zinsmeister, S. Shah, A. Dang Source Type: research

A pediatric case of tick ‐bite–Induced meat allergy and recall urticaria
Alpha-gal syndrome should be suspected also in children in case of typical allergic symptoms in the evening or night during tick seasons and the event of recall urticaria. It is, however, still a challenge for both patients and clinicians. AbstractAlpha-gal syndrome should be suspected also in children in case of typical allergic symptoms in the evening or night during tick seasons and the event of recall urticaria. It is, however, still a challenge for both patients and clinicians.
Source: Clinical Case Reports - September 24, 2021 Category: General Medicine Authors: May Saleem, Caroline Nilsson Tags: CASE REPORT Source Type: research

Allergy to Mammalian Meat Linked to Alpha-Gal Syndrome Potentially After Tick Bite in the Amazon: A Case Series
This study confirms the presence of this new entity in French Guiana and is the largest reported in Latin America. Our results do not clearly allow us to state that tick bites are the cause of this allergy, but all patients reported being exposed regularly to these arthropods.PMID:34544046 | DOI:10.4269/ajtmh.20-1630
Source: Am J Trop Med Hyg - September 20, 2021 Category: Infectious Diseases Authors: Lo ïc Epelboin Florent Roche Maryvonne Dueymes Genevi ève Guillot Olivier Duron Mathieu Nacher F élix Djossou Ang èle Soria Source Type: research

A Case of α-Gal-Unrelated Red Meat-Induced Urticaria Treated by Omalizumab
A 70-year-old healthy woman was referred to our hospital for chronic urticaria. She did not have a history of allergy, asthma, and rhinitis. She was initially diagnosed with α-gal-related urticaria based on an episode of delayed-type urticaria after eating red meat. The results of the intracutaneous allergen test for beef and pork were negative. Fluorenzyme immunoassays specific for IgE against α-gal, beef, and pork were also negative. She was diagnosed with an α-gal -unrelated red meat allergy following the reproduction of urticaria by a food challenge test. The patient was unresponsive to several drugs, including anti...
Source: Case Reports in Dermatology - September 6, 2021 Category: Dermatology Source Type: research

Exceptional occupational allergies due to food of animal origin
CONCLUSIONS: All employees with allergic immediate skin and/or respiratory reactions exposed to proteins of animal origin in the workplace should undergo a careful allergological workup at an early stage. Determination of the specific IgE plays a central role in confirming the diagnosis and it is of great importance in individual cases to include the suspected native material in the skin tests. The course of the disease is generally characterized by a poor prognosis and is commonly associated with a change in occupation.PMID:33877379 | DOI:10.1007/s00105-021-04810-8
Source: Der Hautarzt: Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete - April 20, 2021 Category: Dermatology Authors: H Dickel Source Type: research