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Specialty: Drugs & Pharmacology
Condition: Heart Failure

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Total 434 results found since Jan 2013.

Factors associated with development of nephrotoxicity in patients treated with vancomycin versus daptomycin for severe Gram-positive infections: A practice-based study.
CONCLUSIONS: Nephrotoxicity with VAN was significantly higher than with DAP despite poorer basal renal status in the DAP group. PMID: 30630306 [PubMed - as supplied by publisher]
Source: Revista Espanola de Quimioterapia - January 8, 2019 Category: Drugs & Pharmacology Authors: Barberan J, Mensa J, Artero A, Epelde F, Rodriguez JC, Ruiz-Morales J, Calleja JL, Guerra JM, Martínez-Gil I, Giménez MJ, Granizo JJ, Aguilar L Tags: Rev Esp Quimioter Source Type: research

Betrixaban for Extended Venous Thromboembolism Prophylaxis in High-Risk Hospitalized Patients: Putting the APEX Results into Practice
AbstractAcutely ill hospitalized medical patients remain at high thromboembolic risk for several weeks after discharge. Previous trials with extended-duration thromboprophylaxis using enoxaparin, apixaban, and rivaroxaban failed to achieve acceptable net clinical benefit, largely due to excess of major bleeding. Betrixaban is a novel factor Xa inhibitor with unique pharmacokinetic properties, including low renal clearance, long half-life, and low peak-to-trough ratio. The phase III APEX trial (N = 7513) compared a betrixaban 160 mg loading dose followed by 80 mg once daily for 35–42 days, with enoxaparin 40 mg once...
Source: Drugs - February 5, 2019 Category: Drugs & Pharmacology Source Type: research

Understanding the cardiovascular risk with non-insulin antidiabetic drugs.
Authors: Athyros VG, Imprialos K, Stavropoulos K, Sahinidis A, Doumas M Abstract INTRODUCTION: Diabetes mellitus is a major public health problem with significant macro- and micro-vascular complications. Achievement of glucose control is associated with substantial reduction of micro-vascular events, while the effects of antidiabetic drugs in macro-vascular complications are less clear. This review summarizes and critically discusses the cardiovascular effects of non-insulin antidiabetic agents. Areas covered: A selective literature search of Pubmed was performed regarding the efficacy and safety of non-insulin ant...
Source: Expert Opinion on Drug Safety - February 28, 2019 Category: Drugs & Pharmacology Tags: Expert Opin Drug Saf Source Type: research

An update on the association of protein kinases with cardiovascular diseases.
CONCLUSION: ROCK inhibitors, fasudil and Y27632, have been reported for significant efficiency in dropping vascular smooth muscle cell hyper-contraction, vascular inflammatory cell recruitment, cardiac remodelling and endothelial dysfunction which highlight their role in cardiovascular diseases. PMID: 30864507 [PubMed - as supplied by publisher]
Source: Current Pharmaceutical Design - March 10, 2019 Category: Drugs & Pharmacology Authors: Amin F, Ahmad A, Feroz A, Khaqi SS, Khan MS, Tabrez S, Zaidi SK, Abulaal WH, Shamsi A, Khan W, Bano B Tags: Curr Pharm Des Source Type: research

Dapagliflozin and cardiovascular outcomes: anything else to DECLARE?
Authors: Raschi E, Poluzzi E, Marchesini G, De Ponti F Abstract INTRODUCTION: Individuals with type 2 diabetes mellitus (T2DM) have increased cardiovascular risk with regulatory agencies requiring cardiovascular outcome trials (CVOTs) for the approval of new antidiabetic drugs. Areas covered: In this paper, the authors critically discuss the background, trial design, results and implications of a recent CVOT [NCT01730534; DECLARE-TIMI 58 study], which demonstrated that dapagliflozin was non-inferior to placebo in terms of major adverse cardiovascular events, and superior for the occurrence of hospitalization for he...
Source: Expert Opinion on Pharmacotherapy - March 30, 2019 Category: Drugs & Pharmacology Tags: Expert Opin Pharmacother Source Type: research

YiQiFuMai Powder Injection Attenuates Coronary Artery Ligation-Induced Heart Failure Through Improving Mitochondrial Function via Regulating ROS Generation and CaMKII Signaling Pathways
This study was carried out in accordance with the recommendations of “Guide for the Care and Use of Laboratory Animals, National Institutes of Health.” The protocol was approved by the “China Pharmaceutical University.” Surgical Preparation The mice were anesthetized with chloral hydrate (4% chloral hydrate, ip). The HF model was induced by CAL as previously reported (Gao et al., 2010). Successful ligation of the coronary artery was confirmed by the occurrence of ST-segment elevation in electrocardiogram. Sham operated mice were performed the same process except left CAL. After ligation, the h...
Source: Frontiers in Pharmacology - April 9, 2019 Category: Drugs & Pharmacology Source Type: research

Nrf2 as a Potential Mediator of Cardiovascular Risk in Metabolic Diseases
Conclusion Activation of the Nrf2-dependent antioxidant system plays an important role in cell defense against oxidative stress damage, whereas the insufficiency of the Nrf2 system is associated with multiple aspects of the genesis and progression of metabolic diseases, posing a great risk to the cardiovascular system (Figure 1). The systemic increase of Nrf2 activity by several activators may be beneficial in the treatment of metabolic diseases. In addition, selective upregulation of Nrf2 genes may represent a potential therapy in obesity, diabetes and atherosclerosis. Looking to the future, experimental research that el...
Source: Frontiers in Pharmacology - April 11, 2019 Category: Drugs & Pharmacology Source Type: research

Unintended consequences of the new ACC/AHA blood pressure treatment guidelines.
Authors: Chrysant SG, Chrysant GS Abstract Hypertension is a major risk factor for cardiovascular disease, heart failure, chronic kidney disease and stroke. Therefore, its early detection and treatment are very important according to blood pressure (BP) treatment guidelines issued by the various scientific societies. Over the years, BP treatment guidelines have changed from strict control of BP to more relaxed control, and lately to a strict BP control influenced by the results of the SPRINT trial. The recently published BP treatment guidelines by the American College of Cardiology/American Heart Association (ACC/A...
Source: Drugs of Today - May 7, 2019 Category: Drugs & Pharmacology Tags: Drugs Today (Barc) Source Type: research

The efficacy of simendan in the treatment of acute heart failure and its impact on NT-proBNP.
CONCLUSIONS: Simendan can significantly reduce plasma NT-proBNP level; thus, it is relatively safe and effective for the treatment of acute heart failure (AHF). PMID: 31115032 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - May 24, 2019 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

Population Pharmacokinetics and Pharmacodynamics of Apixaban Linking Its Plasma Concentration to Intrinsic Activated Coagulation Factor X Activity in Japanese Patients with Atrial Fibrillation
In this study, we aimed to elucidate intrinsic factors affecting efficacy of apixaban by conducting population pharmacokinetic and pharmacodynamic analysis using data from 81 Japanese AF patients. The intrinsic FXa activity was determined to assess the pharmacodynamic effect of apixaban. The pharmacokinetic and pharmacodynamic profiles were described based on a one-compartment model with first-order absorption and a maximum inhibitory model, respectively. Pharmacokinetic and pharmacodynamic analysis was conducted using a nonlinear mixed effect modeling program. The population pharmacokinetic parameters of apixaban were fix...
Source: The AAPS Journal - June 23, 2019 Category: Drugs & Pharmacology Source Type: research

Polyphenols regulate endothelial functions and reduce the risk of cardiovascular disease.
CONCLUSION: High intake of dietary polyphenols may help prevent CVD. Polyphenols inhibit endothelial dysfunction and induce vascular endothelium-dependent vascular relaxation viz. redox regulation and nitric oxide production. The polyphenol-induced healthy endothelial cell function may be related to CVD prevention. PMID: 31333108 [PubMed - as supplied by publisher]
Source: Current Pharmaceutical Design - July 20, 2019 Category: Drugs & Pharmacology Authors: Yamagata K Tags: Curr Pharm Des Source Type: research

A review of the role of statins in heart failure treatment.
Abstract Heart failure is a common medical problem in the world, which has a high prevalence in both developed and developing countries. Today, among the medications used for the heart failure treatment, there are many medications with a positive cardiac contraction effect (positive inotropic such as digital glycosides, adrenergic receptor stimulants, and phosphodiesterase inhibitors), a large number of cardiac diluents (such as Angiotensin-converting enzyme (ACE) inhibitor group), and a few other types of drugs whose final effects are still under review Statins are valuable drugs that are broadly prescribed in hy...
Source: Current Clinical Pharmacology - August 1, 2019 Category: Drugs & Pharmacology Authors: Niazi M, Galehdar N, Jamshidi M, Mohammadi R, Moayyedkazemi A Tags: Curr Clin Pharmacol Source Type: research

Efficacy and Safety of Direct Oral Anticoagulants in Patients With Atrial Fibrillation and High Thromboembolic Risk. A Systematic Review
Conclusions: The use of DOACs is a reasonable alternative to vitamin K antagonists in AF patients with CHADS2 score ≥3, advanced age, and HF. The RI constitutes a useful, additional tool to facilitate clinicians in choosing DOACs or warfarin in particular category of AF patients.
Source: Frontiers in Pharmacology - September 18, 2019 Category: Drugs & Pharmacology Source Type: research

Effects of ANP on Pulmonary Vein Electrophysiology, Ca2+ Homeostasis and Adrenergic Arrhythmogenesis via PKA.
In conclusion, ANP directly regulates PV electrophysiological characteristics and Ca2+ homeostasis, and attenuates isoproterenol-induced arrhythmogenesis through NPR-C/cAMP/PKA signal pathway. PMID: 31637746 [PubMed - as supplied by publisher]
Source: Clinical and Experimental Pharmacology and Physiology - October 21, 2019 Category: Drugs & Pharmacology Authors: Lu YY, Cheng CC, Wu HJ, Lin YK, Chen YC, Chen SA, Chen YJ Tags: Clin Exp Pharmacol Physiol Source Type: research

Sacubitril/Valsartan Improves Left Atrial and Left Atrial Appendage Function in Patients With Atrial Fibrillation and in Pressure Overload-Induced Mice
LCZ696 (sacubitril/valsartan) is an angiotensin receptor-neprilysin inhibitor and has shown beneficial effects in patients with heart failure. However, whether LCZ696 protects against left atrial (LA) and LA appendage (LAA) dysfunction is still unclear. The present study aimed to assess the efficacy of LCZ696 for improving the function of LA and LAA. We performed both a retrospective study comparing LCZ696 with angiotensin receptor blockers (ARBs) to assess the efficacy of LCZ696 in patients with atrial fibrillation and an animal study in a mouse model with pressure overload. LA peak systolic strain, LAA emptying flow velo...
Source: Frontiers in Pharmacology - October 28, 2019 Category: Drugs & Pharmacology Source Type: research