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Condition: Heart Attack
Procedure: Transplants

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Total 250 results found since Jan 2013.

No sex-based difference in cardiogenic shock: A post-hoc analysis of the DOREMI trial
CONCLUSION: In patients presenting with CS treated with milrinone or dobutamine, no differences in clinical outcomes were observed between males and females.PMID:35725945 | DOI:10.1016/j.jjcc.2022.06.001
Source: Journal of Cardiology - June 21, 2022 Category: Cardiology Authors: Graeme Prosperi-Porta Pouya Motazedian Pietro Di Santo Richard G Jung Simon Parlow Omar Abdel-Razek Trevor Simard Jordan Hutson Nikita Malhotra Angel Fu F Daniel Ramirez Michael Froeschl Rebecca Mathew Benjamin Hibbert CAPITAL DOREMI investigators Source Type: research

A population cohort analysis of English transplant centers indicates major adverse cardiovascular events after kidney transplantation.
Major adverse cardiovascular event (MACE) rates immediately after kidney transplantation remain uncertain due to heterogeneous reporting in the literature. To clarify this, we retrospectively studied every eligible kidney transplant procedure performed in England between April 1, 2002 and March 31. 2018 with follow-up through August 31, 2019. The primary outcome of interest was MACE broadly defined as any hospital admission with myocardial infarction, stroke, unstable angina, heart failure, any coronary revascularisation procedure and/or any cardiovascular death.
Source: Kidney International - June 15, 2022 Category: Urology & Nephrology Authors: Benjamin Anderson, Muhammad Qasim, Felicity Evison, Suzy Gallier, Jonathan N. Townend, Charles J. Ferro, Adnan Sharif Tags: clinical investigation Source Type: research

CZecking heart failure in patients with advanced chronic kidney disease (Czech HF-CKD): Study protocol
DISCUSSION: This trial will differ from others by: (1) detailed repeated hemodynamic assessment including arteriovenous access flow and (2) by careful assessment of adequate hydration to avoid confusion between HF and water overload.PMID:35676802 | DOI:10.1177/11297298221099843
Source: The Journal of Vascular Access - June 9, 2022 Category: Surgery Authors: Jan Malik Anna Valerianova Satu Sinikka Pesickova Zdenka Hruskova Vladimira Bednarova Pavel Michalek Vladimir Polakovic Vladimir Tesar Source Type: research

103 High rates of venous and arterial thrombotic events in POEMS patients
Conclusion Arterial and venous thromboses are more common in POEMS syndrome than previously reported and appear associated with disease pathology and activity. We propose a management strategy for appropriate thromboprophylaxis in POEMS patients throughout the course of disease. stephen.keddie@nhs.net
Source: Journal of Neurology, Neurosurgery and Psychiatry - May 27, 2022 Category: Neurosurgery Authors: Keddie, S., Sayar, Z., Weatherill, A., Sive, J., Thomas, M., DSa, S., Lunn, M. Tags: Poster Presentations Source Type: research

Defective KIM-1 phagocytosis does not predispose to acute graft dysfunction after kidney transplantation in humans
Introduction: Ischemia reperfusion injury (IRI) is common to several pathologic conditions, including myocardial infarction, stroke, acute kidney injury, and delayed graft function after kidney transplantation1. Clearance of apoptotic and necrotic cells by resident immune or epithelial cellsS1,S2 prevents release of harmful intracellular pro-inflammatory mediators, and is thought to represent an important mechanism to dampen secondary tissue damage and promote repair after acute injury including IRI2, 3, S3, S4.
Source: Kidney International - May 27, 2022 Category: Urology & Nephrology Authors: Rita S. Suri, Ji Yun Lee, Matthew R. Ban, Bradly Shrum, Elena Tutunea-Fatan, Ola Z. Ismail, Steven Leckie, Adam McIntyre, Qingyong Xu, Seung Ho Lee, Sonali de Chickera, Robert A. Hegele, Lakshman Gunaratnam Tags: research letter Source Type: research

Kidney transplantation waiting times and risk of cardiovascular events and mortality: a retrospective observational cohort study in Taiwan
Conclusions Our results demonstrate that early KT is associated with superior long-term cardiovascular outcomes compared with late KT in selected patients with ESRD receiving uncomplicated KT, suggesting that an early KT could be a better treatment option for patients with ESRD who are eligible for transplantation.
Source: BMJ Open - May 24, 2022 Category: General Medicine Authors: Chen, H.-H., Chern, Y.-B., Hsu, C.-Y., Tang, P.-L., Lai, C.-C. Tags: Open access, Epidemiology Source Type: research

The enigmatic role of VCAM-1 expressed by macrophages in mitochondrial metabolism and atherosclerosis
CONCLUSION: We conclude that macrophage-specific VCAM-1 augments mitochondrial biogenesis and DNA oxidation via Cmpk2. Oxidized mitochondrial DNA in plaque macrophages increases inflammation via Sting, resulting in exacerbation of atherosclerosis.PMID:35557156 | DOI:10.1096/fasebj.2022.36.S1.R6141
Source: Atherosclerosis - May 13, 2022 Category: Cardiology Authors: Niranjana Natarajan Jonathan Florentin Scott P O'Neil Lee L Ohayon Partha Dutta Source Type: research

Assessment of Hypertension, Guideline-Directed Counseling, and Outcomes in the ACHD Population
AbstractGuidelines for the diagnosis and treatment of hypertension were published by the American Heart Association (AHA) in 2017. The prevalence of hypertension in adults with congenital heart disease (ACHD) under these guidelines has yet to be characterized. We sought to assess the prevalence, impact, and provider response to hypertension under current guidelines. Data were obtained retrospectively from records of routine clinic visits over a 10  year period. Potential hypertension-related adverse outcomes including stroke, myocardial infarction, surgical intervention for aortic aneurysm, aortic dissection, atrial fibri...
Source: Pediatric Cardiology - April 5, 2022 Category: Cardiology Source Type: research

Antiplatelet agents for chronic kidney disease
CONCLUSIONS: Antiplatelet agents probably reduced myocardial infarction and increased major bleeding, but do not appear to reduce all-cause and cardiovascular death among people with CKD and those treated with dialysis. The treatment effects of antiplatelet agents compared with each other are uncertain.PMID:35224730 | DOI:10.1002/14651858.CD008834.pub4
Source: Cochrane Database of Systematic Reviews - February 28, 2022 Category: General Medicine Authors: Patrizia Natale Suetonia C Palmer Valeria M Saglimbene Marinella Ruospo Mona Razavian Jonathan C Craig Meg J Jardine Angela C Webster Giovanni Fm Strippoli Source Type: research

TAT-RHIM: a more complex issue than expected
Biochem J. 2022 Jan 11:BCJ20210677. doi: 10.1042/BCJ20210677. Online ahead of print.ABSTRACTMurine cytomegalovirus protein M45 contains a RIP homotypic interaction motif (RHIM) that is sufficient to confer protection of infected cells against necroptotic cell death. Mechanistically, the N-terminal region of M45 drives rapid self-assembly into homo-oligomeric amyloid fibrils, and interacts with the endogenous RHIM domains of receptor-interacting protein kinases (RIPK) 1, RIPK3, Z-DNA binding protein 1, and TIR domain-containing adaptor-inducing interferon-β. Remarkably, all four mammalian proteins harbouring such a RHIM do...
Source: The Biochemical Journal - January 11, 2022 Category: Biochemistry Authors: Benedikt Kolbrink Theresa Riebeling Nikolas K Teiwes Claudia Steinem Hubert Kalbacher Ulrich Kunzendorf Stefan Krautwald Source Type: research

Myocardial infarction and factor VIII elevation in a 36-year-old man
We report a 36-year-old man who had a myocardial infarction despite lacking traditional cardiac risk factors. He developed end-stage heart failure and renal insufficiency necessitating a HeartMate II left ventricular assist device (LVAD). While on the transplant list, he experienced two episodes of LVAD thrombosis 6 months apart, prompting device exchange and escalation of anticoagulation therapy. He eventually underwent a successful heart-kidney transplant before suffering an extensive left lower extremity deep vein thrombosis 6 weeks later. A thrombophilia workup revealed elevated factor VIII activity of 319% (normal ran...
Source: Baylor University Medical Center Proceedings - December 31, 2021 Category: Universities & Medical Training Authors: Amit Alam Harsh Doshi Divya N Patel Keval Patel Dreamy James Jesus Almendral Source Type: research