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Condition: Ganglions
Nutrition: Vitamin A

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Total 39 results found since Jan 2013.

Nestin contributes to laser choroidal and retinal neovascularization
CONCLUSIONS: Our results confirmed the presence of nestin in glial (e.g., astrocytes), reactive Müller, and endothelial cells. They demonstrated their critical involvement in a rat model of retinal and choroidal neovascularization experimentally induced using ocular laser impacts.PMID:36284669 | PMC:PMC9514549
Source: Molecular Vision - October 26, 2022 Category: Molecular Biology Authors: Sofiane Miloudi Maud Valensi Mohamed El Sanharawi Marc M Abitbol Francine Behar-Cohen Claudine Versaux-Botteri Source Type: research

Erythropoietin inhibits apoptosis of retinal ganglion cells induced by high glucose through JNK signaling pathway
J Biol Regul Homeost Agents. 2021 Mar 23;35(2). doi: 10.23812/20-646-A. Online ahead of print.ABSTRACTThe aim of this study was to investigate the effect of erythropoietin (EPO) on the apoptosis of retinal ganglion cells (RGCs) induced by high glucose and its mechanism. Rat primary RGCs were extracted to establish high glucose-induced apoptosis models using a 30 mM high-glucose medium. Then flow cytometry, cell counting kit-8 (CCK-8) assay and Western blotting assay were performed to detect the effects of high-, medium- and low-dose EPO on the apoptosis of RGCs induced by high glucose. Next, the molecular mechanism by whic...
Source: Journal of Biological Regulators and Homeostatic Agents - March 23, 2021 Category: Biomedical Science Authors: Y X Qi X J Su L L Wei J Zhang Source Type: research

ASAP Enhanced Delivery of siRNA to Retinal Ganglion Cells by Intravitreal Lipid Nanoparticles of Positive Charge
Molecular PharmaceuticsDOI: 10.1021/acs.molpharmaceut.0c00992
Source: Molecular Pharmaceutics - December 9, 2020 Category: Drugs & Pharmacology Authors: Xiaonan Huang and Ying Chau Source Type: research

The small molecule inhibitor PR-619 protects retinal ganglion cells against glutamate excitotoxicity
This study was designed to investigate the role of PR-619 in regulating mitophagy of RGCs under glutamate excitotoxicity. Primary cultured RGCs were incubated with PR-619 or vehicle control in the excitotoxicity model of 100 µM glutamate treatment. Mitochondrial membrane potential was assessed by JC-1 assay. Cytotoxicity of RGCs was measured by LDH activity. Proteins levels of parkin, optineurin, LAMP1, Bax, Bcl-2 and the LC3-II/I ratio were analyzed by western blot. The distribution and morphology of mitochondria in RGCs was stained by MitoTracker and antibody against mitochondria membrane protein, and examined by confoc...
Source: NeuroReport - October 6, 2020 Category: Neurology Tags: Degeneration and Repair Source Type: research

MTIM affects retinal ganglion cells through PI3K/AKT signaling pathway.
CONCLUSIONS: Up-regulation of MT1M can inhibit RGC cell apoptosis and inflammation, and promote RGC cell proliferation through the PI3K/AKT signaling pathway. PMID: 32495853 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - June 5, 2020 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

Relationship between miR-375 regulating Ndrg2/IL-6/STAT3 signaling pathway and diabetic retinopathy in rats.
CONCLUSIONS: MiR-375 inhibitors are able to reduce blood glucose, retinal permeability, and optic ganglion apoptosis in rats with DR, and the mechanism of action may be related to the regulation on the Ndrg2/IL-6/STAT3 signaling pathway. PMID: 32196570 [PubMed - as supplied by publisher]
Source: European Review for Medical and Pharmacological Sciences - March 21, 2020 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

A method for gene knockdown in the retina using a lipid-based carrier.
Conclusions: This work supports the use of Invivofectamine 3.0 as a transfection agent for effective delivery of nucleic acids to the retina for gene function studies and as potential therapeutics. PMID: 32165826 [PubMed - in process]
Source: Molecular Vision - March 15, 2020 Category: Molecular Biology Tags: Mol Vis Source Type: research

RSK3 mediates necroptosis by regulating phosphorylation of RIP3 in rat retinal ganglion cells.
Abstract Receptor-interacting protein 3 (RIP3) plays an important role in the necroptosis signaling pathway. Our previous studies have shown that the RIP3/mixed lineage kinase domain-like protein (MLKL)-mediated necroptosis occurs in retinal ganglion cell line 5 (RGC-5) following oxygen-glucose deprivation (OGD). However, upstream regulatory pathways of RIP3 are yet to be uncovered. The purpose of the present study was to investigate the role of p90 ribosomal protein S6 kinase 3 (RSK3) in the phosphorylation of RIP3 in RGC-5 cell necroptosis following OGD. Our results showed that expression of RSK3, RIP3, and MLKL...
Source: Journal of Anatomy - March 11, 2020 Category: Anatomy Authors: Wang M, Wan H, Wang S, Liao L, Huang Y, Guo L, Liu F, Shang L, Huang J, Ji D, Xia X, Jiang B, Chen D, Xiong K Tags: J Anat Source Type: research

MicroRNA-30b regulates the polarity of retinal ganglion cells by inhibiting semaphorin-3A.
Conclusions: The results indicate that Sema3A promotes dendritic growth and inhibits axonal growth, which is not conducive to the early repair of optic nerve injury. The overexpression of miR-30b can overcome this problem, and may represent a new target for the treatment of nerve injury and regeneration in the future. PMID: 31814697 [PubMed - in process]
Source: Molecular Vision - December 10, 2019 Category: Molecular Biology Tags: Mol Vis Source Type: research

Kaempferol protects retinal ganglion ceils from high-glucose-induced injury by regulating vasohibin-1
In this study, we explored kaempferol’s role in high-glucose injury in cells from the retinal ganglion cell (RGC) line. RGC cells were isolated and then cultured in high glucose (55 mmol/L) for 0 hours, 12 hours, 24 hours, 48 hours, or 72 hours, and results showed decreased cell viability at 48 hours and 72 hours. We treated RGC cells with different concentrations of kaempferol (0 µmol/L, 20 µmol/L, 40 µmol/L, 60 µmol/L, 80 µmol/L, or 100 µmol/L) and high-glucose (55 mmol/L) for 48 hours. The data indicated inhibited lactate dehydrogenase leakage, apoptosis, caspase-3 activity, and r...
Source: Neuroscience Letters - November 18, 2019 Category: Neuroscience Source Type: research

Involvement of Upregulated P53-Induced Death Domain Protein in Retinal Ganglion Cells Apoptosis after Optic Nerve Crush.
CONCLUSIONS: Taken together, PIDD may play a crucial role in RGCs apoptosis after ONC, and this process may be relevant to caspase-2 and tBid. PMID: 31533600 [PubMed - as supplied by publisher]
Source: Current Molecular Medicine - September 17, 2019 Category: Molecular Biology Authors: Zhang M, Chen L, Xu F, Jiang L, Yan W, Kunwar B, Tang F, Yang K, Shen C, Huang H, Lv J, Qin C, Wu X, Zeng S, Li M, Zhong S, Chen Q Tags: Curr Mol Med Source Type: research

Investigating impacts of surface charge on intraocular distribution of intravitreal lipid nanoparticles.
Abstract In this paper, the effect of surface charge of intravitreal lipid nanoparticles (LNPs) on their intraocular accumulation and distribution was quantitatively and systematically studied. The retinal distribution of LNPs delivering model drug (siRNA) with optimal surface charge was visualized as well. LNPs and siRNA-loaded LNPs (siLNPs) were prepared with ethanol-injection method. C57BL/6 Mice with the age of 6-8 weeks were used for the animal experiments. Quantitative accumulation in the eye and respective intraocular distribution of the intravitreally injected LNPs with different surface charge were examin...
Source: Experimental Eye Research - June 21, 2019 Category: Opthalmology Authors: Huang X, Chau Y Tags: Exp Eye Res Source Type: research