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Condition: Dementia
Procedure: PET Scan

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Total 174 results found since Jan 2013.

Small vessel disease and clinical outcomes after IV rt ‐PA treatment
ConclusionOur results suggest that SVD negatively affects stroke outcomes after intravenous thrombolysis. Although white matter changes seem to be the major driver in relation to worse outcomes, global estimation of SVD is feasible and may provide helpful information.
Source: Acta Neurologica Scandinavica - February 24, 2017 Category: Neurology Authors: F. Arba, D. Inzitari, M. Ali, S. J. Warach, M. Luby, K. R. Lees, Tags: ORIGINAL ARTICLE Source Type: research

Chronic Blood-Brain Barrier Disruption: a case report (P3.275)
Conclusions:WMH-associated BBB disruption maybe exacerbated by acute stroke, and can persist for months after the initial event, as manifest on BBB permeability imaging. These findings may offer insight into the pathophysiology of vascular dementia.Disclosure: Dr. Naqvi has nothing to disclose. Dr. Hitomi has nothing to disclose. Dr. Leigh has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Naqvi, I., Hitomi, E., Leigh, R. Tags: Cerebrovascular Disease Case Reports II Source Type: research

Second death linked to potential antibody treatment for Alzheimer ’s disease
A 65-year-old woman who was receiving a promising experimental treatment to slow the cognitive decline caused by her early Alzheimer’s disease recently died from a massive brain hemorrhage that some researchers link to the drug. The clinical trial death, described in an unpublished case report Science has obtained, is the second thought to be associated with the antibody called lecanemab. The newly disclosed fatality intensifies questions about its safety and how widely lecanemab should be prescribed if ultimately approved by regulators. The woman, who received infusions of the antibody as part of the trial, s...
Source: ScienceNOW - November 28, 2022 Category: Science Source Type: news

Modifiable Lifestyle Factors and Cognitive Function in Older People: A Cross-Sectional Observational Study
Conclusions: Lifestyle factors, such as physical activity, sleep, and social activity appear to be associated with cognitive function among older people. Physical activity and appropriate durations of sleep and conversation are important for cognitive function. Introduction Dementia is a major public health issue worldwide, with a serious burden for patients, caregivers, and society, as well as substantial economic impacts (1). Although the prevalence of late-life cognitive impairment and dementia are expected to increase in future, effective disease-modifying treatments are currently unavailable. Therefore, unders...
Source: Frontiers in Neurology - April 23, 2019 Category: Neurology Source Type: research

Changing clinical patterns and increasing prevalence in CADASIL
ConclusionsCADASIL prevalence is at least 4.6 per 100,000 adults. Median age of first stroke may be older than previously thought. Clinicians should consider CADASIL in the differential diagnosis even in older patients with stroke.
Source: Acta Neurologica Scandinavica - April 1, 2014 Category: Neurology Authors: F. C. Moreton, S. S. M. Razvi, R. Davidson, K. W. Muir Tags: Original Article Source Type: research

Can You Think Yourself Into A Different Person?
For years she had tried to be the perfect wife and mother but now, divorced, with two sons, having gone through another break-up and in despair about her future, she felt as if she’d failed at it all, and she was tired of it. On 6 June 2007 Debbie Hampton, of Greensboro, North Carolina, took an overdose of more than 90 pills – a combination of ten different prescription drugs, some of which she’d stolen from a neighbor’s bedside cabinet. That afternoon, she’d written a note on her computer: “I’ve screwed up this life so bad that there is no place here for me and nothing I can contr...
Source: Science - The Huffington Post - November 19, 2015 Category: Science Source Type: news

Decreased CSF Levels of ß-Amyloid in Patients With Cortical Superficial Siderosis
Conclusions: Our results demonstrate that the presence and extent of cSS are associated with reduced CSF ß-amyloid 42 levels. Further studies are needed to investigate the underlying mechanisms of this association. Introduction Cerebral amyloid angiopathy (CAA)—characterized by the deposition of ß-amyloid in the walls of leptomeningeal vessels—is a common cerebral small vessel disease and a major cause of intracerebral hemorrhage in the elderly (1–3). Furthermore, it has become evident that CAA is associated with cognitive impairment (4). Specifically, it has been shown that ...
Source: Frontiers in Neurology - April 25, 2019 Category: Neurology Source Type: research

A Case of Akinetopsia (P6.246)
CONCLUSIONS:This rare case confirms the the importance of akinetopsia, which has historically well described in the last century and was attributed to the vascular causes, trauma and dementia. In this case a bilateral stroke in the occipital lobes, presumably affecting the V5 area was confirmed by MR. In addition to the rarity of the syndrome, the unawareness of trained personnel for the discrepancy of being able to see objects, but be unaware of motion made treatment and rehabilitation difficult.Study Supported by:no supportDisclosure: Dr. Grisold has nothing to disclose. Dr. Pollanz has nothing to disclose. Dr. Surbö...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Grisold, W., Pollanz, S., Surbock, B., Horvath, B. Tags: Cerebrovascular Disease and Interventional Neurology: Case Reports Source Type: research

PET imaging in ischemic cerebrovascular disease: current status and future directions
Abstract Cerebrovascular diseases are caused by interruption or significant impairment of the blood supply to the brain, which leads to a cascade of metabolic and molecular alterations resulting in functional disturbance and morphological damage. These pathophysiological changes can be assessed by positron emission tomography (PET), which permits the regional measurement of physiological parameters and imaging of the distribution of molecular markers. PET has broadened our understanding of the flow and metabolic thresholds critical for the maintenance of brain function and morphology: in this application, PET has...
Source: Neuroscience Bulletin - October 1, 2014 Category: Neuroscience Source Type: research

Differences in predictors of 5‐year survival over a 10‐year period in two cohorts of elderly nursing home residents in Sweden
ConclusionsThe present results indicate a trend that individuals are older and frailer when admitted to NH and that survival time after admission has been shortened. Hence, the need of daily support and care has increased, irrespective of housing. Also, predictors of survival, possible to influence, have changed.
Source: Scandinavian Journal of Caring Sciences - February 4, 2016 Category: Nursing Authors: Märta Sund Levander, Anna Milberg, Nils Rodhe, Pia Tingström, Ewa Grodzinsky Tags: Empirical Studies Source Type: research

Can chocolate make you smarter?
ConclusionStudies suggesting that chocolate is good for us always grab the headlines. However, as is so often the case, the reality is less clear than the headlines suggest.The current study adds to information about the links between diet and brain function – the way our brain processes and manages information. It found that people who scored better than average on these tests said they ate chocolate more often than people who scored worse than average on the tests. But we don't know why that is.There are quite a few limitations to the study. It's cross-sectional, which means we don't know which came first: the chocol...
Source: NHS News Feed - March 9, 2016 Category: Consumer Health News Tags: Food/diet Mental health Source Type: news

Differences in predictors of 5 ‐year survival over a 10‐year period in two cohorts of elderly nursing home residents in Sweden
ConclusionsThe present results indicate a trend that individuals are older and frailer when admitted to NH and that survival time after admission has been shortened. Hence, the need of daily support and care has increased, irrespective of housing. Also, predictors of survival, possible to influence, have changed.
Source: Scandinavian Journal of Caring Sciences - February 3, 2016 Category: Nursing Authors: M ärta Sund Levander, Anna Milberg, Nils Rodhe, Pia Tingström, Ewa Grodzinsky Tags: Empirical Studies Source Type: research

Mortality of Shift Workers
This study strengthens the evidence of a connection between shift work and all-cause mortality. It also provides support for an association between shift work and mortality of cardiovascular disease. The mechanisms responsible for the association between shift work and disease are probably co mplex and influenced by genetics, lifestyle, sleep, social stress, and disturbed circadian rhythms (7). Further epidemiological studies and experimental studies are needed to explain the causal pathways. One issue would be to find a better variable measuring the circadian phase. Shift work is not a valid proxy since previous studies...
Source: Scandinavian Journal of Work, Environment and Health - January 25, 2017 Category: Occupational Health Tags: Editorial Source Type: research

Harnessing the Four Elements for Mental Health
DiscussionAs detailed above, the “elements” in both a classical and a contemporary sense have effects on our mental health and are potentially modifiable aspects that can be harnessed as therapeutic interventions. The most robust interventional evidence currently available shows tentative support for several use of the elements via horticultural and nature-exposure therapy, green exercise/physical activity, sauna and heat therapy, balneotherapy, and breathing exercises. It should be noted that, in many cases, these interventions were not studied in definitive diagnosed psychiatric disorders and thus it is pre...
Source: Frontiers in Psychiatry - April 23, 2019 Category: Psychiatry Source Type: research

Detecting the vulnerable carotid plaque: the Carotid Artery Multimodality imaging Prognostic study design
Background Carotid artery disease is highly prevalent and a main cause of ischemic stroke and vascular dementia. There is a paucity of information on predictors of serious vascular events. Besides percentage diameter stenosis, international guidelines also recommend the evaluation of qualitative characteristics of carotid artery disease as a guide to treatment, but with no agreement on which qualitative features to assess. This inadequate knowledge leads to a poor ability to identify patients at risk, dispersion of medical resources, and unproven use of expensive and resource-consuming techniques, such as magnetic reso...
Source: Journal of Cardiovascular Medicine - July 1, 2022 Category: Cardiology Tags: Research articles: Study design Source Type: research