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Specialty: Neurology
Condition: Dementia

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Total 1006 results found since Jan 2013.

Late-onset epilepsy predicts stroke: Systematic review and meta-analysis.
Abstract OBJECTIVE: Late-onset epilepsy (LOE) is closely associated with cerebrovascular disease, acting as both a marker of cerebrovascular disease (CVD) and occurring as a direct consequence. Despite this, our understanding of LOE as a cerebrovascular phenomenon is in its infancy. LOE also appears to be a harbinger of dementia. METHODS: A systematic review was performed to identify publications relating to LOE and identified observational studies, clinical studies, and radiological studies. RESULTS: A meta-analysis of observational studies demonstrated that patients presenting with LOE experience an in...
Source: Epilepsy and Behaviour - December 14, 2020 Category: Neurology Authors: Wall J, Knight J, Emsley HCA Tags: Epilepsy Behav Source Type: research

Cause-Specific Mortality as a Sequalae of Perioperative Stroke Following Cardiac and Vascular Surgery
In this study, we aim to establish the risk of cause-specific mortality associated with perioperative stroke following cardiac and vascular procedures at 30 days, 90 days, and 1-year postoperative. It is hoped that this fund of knowledge will enhance perioperative risk stratification and medical management for patients who have suffered a perioperative stroke. Methods: This is a retrospective cohort study evaluating 277,654 cardiac and vascular surgical patients dually documented within the Inpatient Discharge Claims Database and the Pennsylvania Department of Health Death Statistics database. A univariate assessmen...
Source: The Neurologist - January 1, 2022 Category: Neurology Tags: Original Article Source Type: research

FUS aggregation following ischemic stroke favors brain astrocyte activation through inducing excessive autophagy
In conclusion, our results reveal the important contribution of FUS aggregates in promoting astrocyte activation in stroke pathology independent of its transcriptional regulation activity. We thus propose that aggregation of FUS is an important pathological process in ischemic stroke and targeting FUS aggregates might be of unique therapeutic value in the development of future treatment strategies for ischemic stroke.PMID:35718207 | DOI:10.1016/j.expneurol.2022.114144
Source: Experimental Neurology - June 19, 2022 Category: Neurology Authors: Shusheng Wu Yuye Yin Longfei Du Source Type: research

Clinical Biomarkers and Prediction Models for Poststroke Epilepsy: Have We Settled the Scores Yet?
In an era of time-dependent reperfusion and recanalization therapy for stroke leading to improved survival, there is a growing population at risk of poststroke epilepsy (PSE). Accumulating evidence suggests a multidirectional interaction among stroke, PSE, and dementia in stroke survivors. There is no evidence to justify prophylactic antiseizure medication (ASM) to reduce these morbidities. Although several predictive molecular biomarkers and scoring models have been proposed, they remain inadequately validated for stratifying risk and indicating who will benefit from prophylactic ASM. Studies leveraging advances in geneti...
Source: Neurology Clinical Practice - March 14, 2023 Category: Neurology Authors: Yonas, A. S., Meschia, J. F., Feyissa, A. M. Tags: Stroke in young adults, All Cerebrovascular disease/Stroke, EEG; see Epilepsy/Seizures, Screening in epidemiology, All Epilepsy/Seizures Commentary Source Type: research

Prediction of long-term mortality in patients with ischemic stroke based on clinical characteristics on the first day of ICU admission: An easy-to-use nomogram
ConclusionThis proposed nomogram has good performance in predicting long-term mortality among ischemic stroke patients.
Source: Frontiers in Neurology - April 14, 2023 Category: Neurology Source Type: research

Alzheimer disease and risk of stroke: A population-based cohort study
Conclusion: Clinical diagnosis of AD is associated with considerably increased risk of stroke development.
Source: Neurology - February 18, 2013 Category: Neurology Authors: Chi, N.-F., Chien, L.-N., Ku, H.-L., Hu, C.-J., Chiou, H.-Y. Tags: Alzheimer's disease, Infarction, Intracerebral hemorrhage ARTICLE Source Type: research

Prevalence, Incidence and Associated Risk Factors of Stroke in Older Adults in Havana and Matanzas Provinces, Cuba (P03.152)
CONCLUSIONS: Prevalence and incidence of stroke in this study is similar to that reported for Europe and North America, and higher than that observed in other Latin American countries. The risk profile identified includes classic risk factors plus anemia and APOE 4 genotype.Disclosure: Dr. Lombardi has nothing to disclose. Dr. Valhuerdy has nothing to disclose. Dr. Fernández has nothing to disclose. Dr. Llibre has nothing to disclose.
Source: Neurology - February 14, 2013 Category: Neurology Authors: Llibre, J., Valhuerdy, A., Fernandez, O., Llibre, J. Tags: P03 Cerebrovascular Disease III Source Type: research

Profile and determinants of vascular cognitive impairment in African stroke survivors: The CogFAST Nigeria Study
Sub-Saharan Africa faces a potential epidemic of non-communicable diseases including stroke and dementia but little is known about the burden of stroke-related cognitive dysfunction. We assessed the baseline profile and factors associated with vascular cognitive impairment (VCI) in stroke survivors participating in the Cognitive Function After STroke (CogFAST) Nigeria Study.
Source: Journal of the Neurological Sciences - September 1, 2014 Category: Neurology Authors: Rufus O. Akinyemi, Louise Allan, Mayowa O. Owolabi, Joshua O. Akinyemi, Godwin Ogbole, Akinlolu Ajani, Michael Firbank, Adesola Ogunniyi, Raj N. Kalaria Source Type: research

Tactile unawareness in acute right hemispheric stroke (P1.207)
CONCLUSIONS:Tactile unawareness is common in acute right MCA stroke. Bedside findings can help dissociate primary sensory deficit from somatosensory hemi-inattention. The importance of spatial attention in tactile awareness is substantiated by the lesion sites associated with the disorder: regions crucial for multi-sensory integration and bodily awareness. Study Supported by:Disclosure: Dr. Antoniello has nothing to disclose. Dr. Gottesman has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Antoniello, D., Gottesman, R. Tags: Aging, Dementia, Cognitive, and Behavioral Neurology: Attention and Aphasia Source Type: research

Altered resting-state network connectivity in stroke patients with and without apraxia of speech (S49.002)
CONCLUSIONS: These results highlight the left PM region’s involvement in AOS, begin to differentiate it’s neural mechanisms from those of other motor impairments following stroke, and help inform us of the neural mechanisms driving differences in speech motor planning and programming following stroke. Study Supported by: National Health and Medical Research Council Project Grant 632763Disclosure: Dr. New has nothing to disclose. Dr. Kirrie has nothing to disclose. Dr. Parkinson has nothing to disclose. Dr. Duffy has nothing to disclose. Dr. McNeil has nothing to disclose. Dr. Piguet has nothing to disclose. Dr....
Source: Neurology - April 8, 2015 Category: Neurology Authors: New, A., Kirrie, B., Parkinson, A., Duffy, J., McNeil, M., Piguet, O., Hornberger, M., Price, C., Eickhoff, S., Robin, D. Tags: Aging, Dementia, Cognitive, and Behavioral Neurology: Imaging: Behavioral Neurology and non-Alzheimer ' s Disease Dementias Source Type: research

Ocular Fundus Photography as a Tool to Study Stroke and Dementia
Semin Neurol 2015; 35: 481-490DOI: 10.1055/s-0035-1563570Although cerebral small vessel disease has been linked to stroke and dementia, due to limitations of current neuroimaging technology, direct in vivo visualization of changes in the cerebral small vessels (e.g., cerebral arteriolar narrowing, tortuous microvessels, blood–brain barrier damage, capillary microaneurysms) is difficult to achieve. As the retina and the brain share similar embryological origin, anatomical features, and physiologic properties with the cerebral small vessels, the retinal vessels offer a unique and easily accessible “window” to study the...
Source: Seminars in Neurology - October 6, 2015 Category: Neurology Authors: Cheung, Carol Y.Chen, ChristopherWong, Tien Y. Source Type: research

Montreal Cognitive Assessment: One Cutoff Never Fits All Brief Reports
Conclusions— Conventional single cutoff scores are associated with substantially high rates of misclassification especially in older and less-educated patients with stroke. These results caution against the use of one-size-fits-all cutoffs on the MoCA.
Source: Stroke - November 23, 2015 Category: Neurology Authors: Wong, A., Law, L. S. N., Liu, W., Wang, Z., Lo, E. S. K., Lau, A., Wong, L. K. S., Mok, V. C. T. Tags: Rehabilitation, Cognitive Impairment Brief Reports Source Type: research

Intracranial and Extracranial Stenosis interact with White Matter Disease in the Pathogenesis of Post Stroke Dementia (P5.210)
Conclusions: Patients with concomitant extracranial and intracranial stenosis have highest risks of developing PSD. Burden of WMH further influences the impact of stenosis on cognition.Disclosure: Dr. Ben Wee has nothing to disclose. Dr. Choong has nothing to disclose. Dr. Chander has nothing to disclose. Dr. Kandiah has received honorarium and CME sponsorship from Lundbeck, Novartis and Eisai.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Ben Wee, C., Choong, A., Chander, R., Kandiah, N. Tags: Aging and Dementia: Disease Models and Mechanisms Source Type: research