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Total 430 results found since Jan 2013.

Are You Getting Older - Or Are You Getting Sleep Apnea?
By Brandon R. Peters, MD As my 81-year-old grandma likes to remind me on occasion, "It's hell to get old." More than a nuisance, the cumulative decline that comes with aging can significantly compromise one's quality of life and health. What if some of the problems so often associated with growing older didn't need to occur? Better yet, what if some of these physical and mental impairments could be reversed? Consider the role of sleep apnea as an unexpected contributor to many ailments erroneously attributed to aging and the reversals possible with effective treatment. Sleep Changes with Age It is clear that sleep chang...
Source: Healthy Living - The Huffington Post - November 15, 2016 Category: Consumer Health News Source Type: news

Aerobic exercise and vascular cognitive impairment: A randomized controlled trial
Conclusions: This study provides preliminary evidence for the efficacy of 6 months of thrice-weekly progressive aerobic training in community-dwelling adults with mild SIVCI, relative to usual care plus education. ClinicalTrials.gov identifier: NCT01027858. Classification of evidence: This study provides Class II evidence that for adults with mild SIVCI, an aerobic exercise program for 6 months results in a small, significant improvement in ADAS-Cog performance.
Source: Neurology - November 13, 2016 Category: Neurology Authors: Liu-Ambrose, T., Best, J. R., Davis, J. C., Eng, J. J., Lee, P. E., Jacova, C., Boyd, L. A., Brasher, P. M., Munkacsy, M., Cheung, W., Hsiung, G.-Y. R. Tags: All Cerebrovascular disease/Stroke, Clinical trials Randomized controlled (CONSORT agreement), Vascular dementia, Class I ARTICLE Source Type: research

Prevalence and Risk Factors of Caregiver Dependence among Older Adults in a Southeast Asian Population.
CONCLUSION: Various sociodemographic and health-related conditions were significantly associated with caregiver dependence. Dependent older adults will put greater demands on health and social services, resulting in greater healthcare expenditures. Hence, effective planning, services and support are crucial to meet the needs of dependent older adults and their caregivers. PMID: 27922142 [PubMed - in process]
Source: Annals of the Academy of Medicine, Singapore - October 31, 2016 Category: Journals (General) Authors: Picco L, Abdin E, Vaingankar JA, Pang S, Shafie S, Sambasivam R, Chong SA, Subramaniam M Tags: Ann Acad Med Singapore Source Type: research

Early life characteristics and late life burden of cerebral small vessel disease in the Lothian Birth Cohort 1936.
Abstract It is unknown whether relations between early-life factors and overall health in later life apply to burden of cerebral small vessel disease (cSVD), a major cause of stroke and dementia. We explored relations between early-life factors and cSVD in the Lothian Birth Cohort, a healthy aging cohort. Participants were recruited at age 70 (N = 1091); most had completed a test of cognitive ability at age 11 as part of the Scottish Mental Survey of 1947. Of those, 700 participants had brain MRI that could be rated for cSVD conducted at age 73. Presence of lacunes, white matter hyperintensities, microbleeds, and ...
Source: Aging - September 18, 2016 Category: Biomedical Science Authors: Field TS, Doubal FN, Johnson W, Backhouse E, McHutchison C, Cox S, Corley J, Pattie A, Gow AJ, Shenkin S, Cvoro V, Morris Z, Staals J, Bastin M, Deary IJ, Wardlaw JM Tags: Aging (Albany NY) Source Type: research

Sleep Duration and White Matter Quality in Middle-Aged Adults
Conclusions:Short sleep duration was associated with worse markers of white matter integrity in midlife. These mid-life differences in white matter may underlie the link between poor sleep and risk of dementia and stroke.Citation:Yaffe K, Nasrallah I, Hoang TD, Lauderdale DS, Knutson KL, Carnethon MR, Launer LJ, Lewis CE, Sidney S. Sleep duration and white matter quality in middle-aged adults.SLEEP 2016;39(9):1743–1747.
Source: Sleep - August 31, 2016 Category: Sleep Medicine Source Type: research

Pulse Pressure Is Associated With Early Brain Atrophy and Cognitive Decline: Modifying Effects of APOE- ε4.
Pulse Pressure Is Associated With Early Brain Atrophy and Cognitive Decline: Modifying Effects of APOE-ε4. Alzheimer Dis Assoc Disord. 2016 Jul-Sep;30(3):210-5 Authors: Nation DA, Preis SR, Beiser A, Bangen KJ, Delano-Wood L, Lamar M, Libon DJ, Seshadri S, Wolf PA, Au R Abstract We investigated whether midlife pulse pressure is associated with brain atrophy and cognitive decline, and whether the association was modified by apolipoprotein-E ε4 (APOE-ε4) and hypertension. Participants (549 stroke-free and dementia-free Framingham Offspring Cohort Study participants, age range=55.0 to 64.9 y) underwent...
Source: Alzheimer Disease and Associated Disorders - August 26, 2016 Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research

China's shift from population control to population quality: Implications for neurology
China's population restriction, known across the globe as the 1-child policy, has been in place since 1981, with variations to allow some couples a second child.1,2 In response to social challenges arising from this policy, the Chinese government announced in 2015 that it would transition to a new 2-child policy, encouraging couples since January 1, 2016, to have 2 children.3 This transition accompanies a focus on population quality (i.e., improvements in health, education, and social welfare) in newborns to the large Chinese elderly population, with an initiative to reform the Chinese health care system and increase disea...
Source: Neurology - August 21, 2016 Category: Neurology Authors: Ke, Q., Zhang, L., He, C., Zhao, Z., Qi, M., Griggs, R. C., Gatheridge, M. A. Tags: Stroke prevention, All Neuromuscular Disease, All Cognitive Disorders/Dementia GLOBAL PERSPECTIVES Source Type: research

Calcium supplements linked to post-stroke dementia in women
Conclusion The media paint this as a troubling study for older women who take calcium to strengthen their bones. However the small size of the study (only 98 women took calcium supplements, and only 14 of those got dementia) and its observational nature mean that we cannot rely on the results. As the researchers mention, it is possible that those taking supplements were less healthy than those that didn't in some unmeasured way. Further research may improve our confidence in these results. Broken bones are not a trivial matter for older people – a broken hip can be the difference between being able to live independentl...
Source: NHS News Feed - August 18, 2016 Category: Consumer Health News Tags: Neurology Medication Older people Source Type: news

Relations between Recent Past Leisure Activities with Risks of Dementia and Cognitive Functions after Stroke
by Adrian Wong, Alexander Y. L. Lau, Eugene Lo, Michael Tang, Zhaolu Wang, Wenyan Liu, Nicole Tanner, Natalie Chau, Lorraine Law, Lin Shi, Winnie C. W. Chu, Jie Yang, Yun-yun Xiong, Bonnie Y. K. Lam, Lisa Au, Anne Y. Y. Chan, Yannie Soo, Thomas W. H. Leung, Lawrence K. S. Wong, Linda C. W. Lam, Vincent C. T. Mok Background Leisure activity participation has been shown to lower risks of cognitive decline in non-stroke populations. However, effects of leisure activities participation upon cognitive functions and risk of dementia after stroke are unclear. The purpose of this study is to examine the effects of recent past lei...
Source: PLoS One - July 24, 2016 Category: Biomedical Science Authors: Adrian Wong Source Type: research

Attitudes of neurology specialists toward older adults.
CONCLUSIONS: Generalization of geriatrics education may translate into a better understanding and improved care for older patients. Development of instruments and implementation of qualitative studies to assess attitudes of neurologists toward older adults are needed. PMID: 27456680 [PubMed - as supplied by publisher]
Source: Aging Clinical and Experimental Research - July 24, 2016 Category: Geriatrics Authors: Seferoğlu M, Yıldız D, Pekel NB, Güneş A, Yıldız A, Tufan F Tags: Aging Clin Exp Res Source Type: research

The Diagnostic Utility of the NINDS-CSN Neuropsychological Battery in Memory Clinics
Conclusion: The NINDS-CSN neuropsychological battery can be applied in memory clinics and effectively discriminate between cognitively intact individuals and those with cognitive impairments of varying severity. Furthermore, level of education should be taken into consideration when choosing protocols with different lengths for cognitive assessment.Dement Geriatr Cogn Disord Extra 2016;6:276-282
Source: Dementia and Geriatric Cognitive Disorders Extra - July 14, 2016 Category: Geriatrics Source Type: research

Pulse Pressure Is Associated With Early Brain Atrophy and Cognitive Decline: Modifying Effects of APOE-ε4
We investigated whether midlife pulse pressure is associated with brain atrophy and cognitive decline, and whether the association was modified by apolipoprotein-E ε4 (APOE-ε4) and hypertension. Participants (549 stroke-free and dementia-free Framingham Offspring Cohort Study participants, age range=55.0 to 64.9 y) underwent baseline neuropsychological and magnetic resonance imaging (subset, n=454) evaluations with 5- to 7-year follow-up. Regression analyses investigated associations between baseline pulse pressure (systolic−diastolic pressure) and cognition, total cerebral volume and temporal horn ventricular volume (...
Source: Alzheimer Disease and Associated Disorders - July 1, 2016 Category: Geriatrics Tags: Original Articles Source Type: research

Disability in Singapore's Elderly Population.
CONCLUSION: The findings highlighted specific factors associated with disability in this multiethnic population. The identification of these factors would lead the way to the development of appropriate interventions. PMID: 27523509 [PubMed - in process]
Source: Annals of the Academy of Medicine, Singapore - June 30, 2016 Category: Journals (General) Authors: Mahesh M, Abdin E, Vaingankar JA, Picco L, Jeyagurunathan A, Shafie SB, Pang S, Sagayadevan V, Seow E, Chong SA, Subramaniam M Tags: Ann Acad Med Singapore Source Type: research

Delayed-onset dementia after stroke or transient ischemic attack.
DISCUSSION: Severe SVD contributes importantly to delayed-onset dementia after stroke and/or TIA. Future clinical trials aiming to prevent delayed-onset dementia after stroke and/or TIA should target this high-risk group. PMID: 27327542 [PubMed - as supplied by publisher]
Source: The Journal of Alzheimers Association - June 23, 2016 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Delayed-onset dementia after stroke or transient ischemic attack
Discussion Severe SVD contributes importantly to delayed-onset dementia after stroke and/or TIA. Future clinical trials aiming to prevent delayed-onset dementia after stroke and/or TIA should target this high-risk group.
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - June 17, 2016 Category: Geriatrics Source Type: research