• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

An efficient single-cell based method for linking human T cell phenotype to T cell receptor sequence and specificity
This article is protected by copyright. All rights reserved.PMID:34710239 | DOI:10.1002/eji.202149392
Source: European Journal of Immunology - October 28, 2021 Category: Allergy & Immunology Authors: Ilka Wahl Sandro Hoffmann Rebecca Hundsdorfer Julia Puchan Stephen L Hoffman Peter G Kremsner Benjamin Mordm üller Christian E Busse Hedda Wardemann Source Type: research

Brief Report: Tolerability of COVID-19 Vaccines, BNT162b2 and mRNA-1273, in Patients with Thymic Epithelial Tumors
CONCLUSIONS: Tolerability of COVID-19 mRNA vaccines in patients with TETs is comparable to the general population. Most patients with pre-existing AD did not experience disease flares and the development of new AD was rare. Patients with TETs should be encouraged to get vaccinated against COVID-19 due to the documented benefits of vaccination and manageable risk profile.PMID:34514444 | PMC:PMC8423742 | DOI:10.1016/j.jtocrr.2021.100229
Source: Clinical Lung Cancer - September 13, 2021 Category: Cancer & Oncology Authors: Madison Ballman Shannon Swift Cristina Mullenix Yvonne Mallory Chen Zhao Eva Szabo Meenakshi Shelat Susan Sansone Seth M Steinberg Meredith J McAdams Arun Rajan Source Type: research

Fight Aging! Newsletter, August 30th 2021
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out mo...
Source: Fight Aging! - August 29, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Administration of COVID-19 vaccines in immunocompromised patients
Int Immunopharmacol. 2021 Jul 28;99:108021. doi: 10.1016/j.intimp.2021.108021. Online ahead of print.ABSTRACTSince the beginning of vaccination programs against COVID-19 in different countries, several populations such as patients with specific immunological conditions have been considered as the priorities for immunization. In this regard, patients with autoimmune diseases or those receiving immunosuppressive agents and anti-cancer therapies, need special attention. However, no confirmed data is presently available regarding COVID-19 vaccines in these populations due to exclusion from the conducted clinical trials. Given ...
Source: International Immunopharmacology - August 5, 2021 Category: Allergy & Immunology Authors: Manica Negahdaripour Mojtaba Shafiekhani Seyed Mohammad Iman Moezzi Sogand Amiri Shiva Rasekh Ashkan Bagheri Pouria Mosaddeghi Afsaneh Vazin Source Type: research

Clinical translation of immunomodulatory therapeutics
Adv Drug Deliv Rev. 2021 Jul 26:113896. doi: 10.1016/j.addr.2021.113896. Online ahead of print.ABSTRACTImmunomodulatory therapeutics represent a unique class of drug products that have tremendous potential to allow for rebalance ing of a malfunctioning immune systems and are quickly becoming one of the fastest growing areas in the pharmaceutical industry. However, many challenges related to precision dosing, off-target effects, and manufacturing hurdles will need to be addressed before we see widespread adoption of these therapies in the clinic. For these drugs to become mainstream medicines, they must provide more therape...
Source: Advanced Drug Delivery Reviews - July 29, 2021 Category: Drugs & Pharmacology Authors: Amanda Nash Samira Aghlara-Fotovat Andrea Hernandez Christopher Scull Omid Veiseh Source Type: research

NIDCR's Summer 2021 E-Newsletter
Having trouble viewing this email? View it as a Web page. NIDCR's Summer 2021 E-Newsletter In this issue: NIDCR News Funding Opportunities & Related Notices NIH/HHS News Subscribe to NICDR News Science Advances   Grantee News   NIDCR News NIDCR to Release Report on Oral Health in America As a 20-year follow-up to the seminal Oral Health in America: A Report of the Surgeon General, NIDCR will release Oral Health in America: Advances and Challenges in the fall of 2021. The report will illuminate new directions in the prevention and t...
Source: NIDCR Science News - July 1, 2021 Category: Dentistry Source Type: news

CTL ELISPOT Assay and T Cell Detection
Methods Mol Biol. 2021;2325:65-77. doi: 10.1007/978-1-0716-1507-2_5.ABSTRACTEnzyme-linked immune absorbent spot (Elispot) is a quantitative method for measuring relevant parameters of T-cell activation. The sensitivity of Elispot allows the detection of low-frequency antigen-specific T-cells that secrete cytokines and effector molecules, such as granzyme B and perforin. Cytotoxic T-cell (CTL) studies have taken advantage with this high-throughput technology by providing insights of quantity and immune kinetics. Accuracy, sensitivity, reproducibility, and robustness of Elispot resulted in a wide range of applications in res...
Source: Mol Biol Cell - May 30, 2021 Category: Molecular Biology Authors: Elena Ranieri Giuseppe Stefano Netti Margherita Gigante Source Type: research

Modulating T Follicular Cells In  Vivo Enhances Antigen-Specific Humoral Immunity
In this study, we sought to improve Ag-specific IgG responses with two interventions intended to transiently diminish TFR cell influence. First, adult mice were administered an antibiotic mixture (ABX) for an extended period to deplete the immunoregulatory intestinal microbiota. This intriguingly increased TFH cell and reduced TFR cell numbers. 2,4,6-Trinitrophenyl hapten conjugated to keyhole limpet hemocyanin immunization resulted in higher affinity 2,4,6-trinitrophenyl hapten-specific IgG1 in ABX mice compared with controls. In a model of IgG-driven inflammatory nephritis, ABX mice had significantly worse nephritis acco...
Source: Journal of Immunology - May 20, 2021 Category: Allergy & Immunology Authors: Jose D Pagan Hera Vlamakis Anthony Gaca Ramnik J Xavier Robert M Anthony Source Type: research

Fight Aging! Newsletter, May 10th 2021
This study suggests that some of those changes contribute to age-related hypertension, providing yet another reason to put resources into the near term development of therapies that can reverse the aging of the gut microbiome, such as flagellin vaccination or fecal microbiota transplantation. "Previous studies from our lab have shown that the composition of the gut microbiota in animal models of hypertension, such as the SHRSP (spontaneously hypertensive stroke-prone) rat model, is different from that in animals with normal blood pressure. Further, transplanting dysbiotic gut microbiota from a hypertensive animal ...
Source: Fight Aging! - May 9, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

COVID-19 Vaccine Concerns: Fact or Fiction?
Exp Clin Transplant. 2021 Mar 31. doi: 10.6002/ect.2021.0056. Online ahead of print.ABSTRACTOne year has elapsed since a team of Chinese scientists reported the first case of COVID-19 in Wuhan, China on January 8, 2020, after sequencing the first viral genetic material. Since then, many vaccines were rushed into testing, bypassing animal experimentations, with more than 200 pharma companies in different countries declaring the development of different vaccines, each with their own strategy for generating immunity, despite the arguments of many infectious disease experts that 18 months for a first vaccine is an incredibly a...
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - April 20, 2021 Category: Transplant Surgery Authors: Antoine Barbari Source Type: research

Pages: 1  2  3  4  5  6  7  8  9  10  11  12  13