Filtered By:
Condition: Autoimmune Disease
Procedure: Transplants
This page shows you your search results in order of date.
Order by Relevance | Date
Total 144 results found since Jan 2013.
Perspectives on Mycophenolate Mofetil in the Management of Autoimmunity
Clin Rev Allergy Immunol. 2023 Jun 20. doi: 10.1007/s12016-023-08963-3. Online ahead of print.ABSTRACTBefore becoming a cornerstone in the treatment of numerous immune-mediated diseases, mycophenolate mofetil (MMF) was first introduced as an immunosuppressive agent in transplant immunology and later received the attention of rheumatologists and clinicians involved in the management of autoimmune diseases. MMF is now a widespread immunosuppressive drug for the treatment of several conditions, including lupus nephritis, interstitial lung disease associated with systemic sclerosis, and anti-neutrophil cytoplasm antibody (ANCA...
Source: Clinical Lung Cancer - June 20, 2023 Category: Cancer & Oncology Authors: Rithika Bhat Antonio Tonutti Suraj Timilsina Carlo Selmi M Eric Gershwin Source Type: research
The role of PD-1 signaling in health and immune-related diseases
Programmed cell death 1 receptor (PD-1) and its ligands constitute an inhibitory pathway to mediate the mechanism of immune tolerance and provide immune homeostasis. Significantly, the binding partners of PD-1 and its associated ligands are diverse, which facilitates immunosuppression in cooperation with other immune checkpoint proteins. Accumulating evidence has demonstrated the important immunosuppressive role of the PD-1 axis in the tumor microenvironment and in autoimmune diseases. In addition, PD-1 blockades have been approved to treat various cancers, including solid tumors and hematological malignancies. Here, we pr...
Source: Frontiers in Immunology - May 16, 2023 Category: Allergy & Immunology Source Type: research
Immunosuppressive Polymeric Nanoparticles Targeting Dendritic Cells Alleviate Lupus Disease in < em > Fcgr2b < /em > < sup > -/- < /sup > Mice by Mediating Antigen-Specific Immune Tolerance
This study developed a new nanoparticle (NP) containing a biodegradable PDMAEMA-PLGA copolymer for target-oriented delivery to DCs in situ. PDMAEMA-PLGA NPs provided sustained drug release and exhibited immunosuppressive activity in FLT3L and GM-CSF-derived bone marrow in conventional DCs (BM-cDCs). PDMAEMA-PLGA NPs improved dexamethasone capability to convert wild-type and Fcgr2b-/- BM-cDCs from an immunogenic to tolerogenic state, and BM-cDCs treated with dexamethasone-incorporated PDMAEMA-PLGA NPs (Dex-NPs) efficiently mediated regulatory T cell (Treg) expansion in vitro. Dex-NP therapy potentially alleviated lupus dise...
Source: Cell Research - May 13, 2023 Category: Cytology Authors: Phuriwat Khiewkamrop Chamraj Kaewraemruaen Chonnavee Manipuntee Chalathan Saengruengrit Numpon Insin Asada Leelahavanichkul Warerat Kaewduangduen Opor Sonpoung Kasirapat Ariya-Anandech Nattiya Hirankarn Patcharee Ritprajak Source Type: research
Autoimmune manifestations in VEXAS: Opportunities for integration and pitfalls to interpretation
VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) is a novel entity manifesting with a multiplicity of clinical features. Somatic mutations of the UBA1 gene in hematopoietic stem cells constitute the genetic basis of VEXAS. As an X-linked disorder, most cases occur in men, classically developing symptoms during the fifth to sixth decade of life. Considering its multidisciplinary nature involving numerous branches of internal medicine, VEXAS has elicited a wide medical interest and several medical conditions have been associated with this disease.
Source: Journal of Allergy and Clinical Immunology - March 20, 2023 Category: Allergy & Immunology Authors: Alessandro Bruno, Carmelo Gurnari, Tobias Alexander, John A. Snowden, Raffaella Greco, Autoimmune Diseases Working Party of the European Society for Blood and Marrow Transplantation Source Type: research
The Adaptation Model of Immunity: Signal IV Matters Most in Determining the Functional Outcomes of Immune Responses
J Immunol. 2023 Mar 1;210(5):521-530. doi: 10.4049/jimmunol.2200672.ABSTRACTCurrent research in immunology and immunotherapy is fully influenced by the self-nonself model of immunity. This theoretical model suggests that alloreactivity results in graft rejection, whereas tolerance toward self-antigens expressed by malignant cells facilitates cancer development. Similarly, breakage of immunological tolerance toward self-antigens results in autoimmune diseases. Accordingly, immune suppression is recommended for the management of autoimmune diseases, allergy, and organ transplantation, whereas immune inducers are used for the...
Source: Journal of Immunology - March 7, 2023 Category: Allergy & Immunology Authors: Masoud H Manjili Source Type: research
The Evolving Landscape of Fecal Microbial Transplantation
AbstractThe human gastrointestinal tract houses an enormous microbial ecosystem. Recent studies have shown that the gut microbiota plays significant physiological roles and maintains immune homeostasis in the human body. Dysbiosis, an imbalanced gut microbiome, can be associated with various disease states, as observed in infectious diseases, inflammatory diseases, autoimmune diseases, and cancer. Modulation of the gut microbiome has become a therapeutic target in treating these disorders. Fecal microbiota transplantation (FMT) from a healthy donor restores the normal gut microbiota homeostasis in the diseased host. Ample ...
Source: Clinical Reviews in Allergy and Immunology - February 9, 2023 Category: Allergy & Immunology Source Type: research
Science ’s 2022 Breakthrough of the Year: A telescope’s golden eye sees the universe anew
html { scroll-behavior: smooth; } .news-article-content--featured>.bodySection>.mb-2x:not(:first-of-type) { display: none; } h3 { scroll-margin-top: 5rem; } .parent-section h3, .subsection h3 { font-size: 1.375rem; line-height: 1.875rem; } .news-article-content-footer h2 { display: none; } .toc img { padding-bottom: 16px; transition: opacity .25s; } .toc img:hover { opacity: 60%; } .toc .image-grid img { padding-bottom: 16px; padding-top: 16px; } .image-grid .news-article__figure__image__wrapper:before, .image-grid .news-article__figure__image__wrapper:after { display: none; } .news-article-content sectio...
Source: ScienceNOW - December 15, 2022 Category: Science Source Type: news
The T Cell Receptor Repertoire Diversity Following Hematopoietic Stem Cell Transplantation
This study aimed to assess the T cell receptor (TCR) repertoire diversity in CD4+ cells of patients with hematological malignancies who received allogeneic or autologous HSCT. The diversity of the TCR repertoire was evaluated in 13 patients with hematologic malignancies before and four months after HSCT. Amino acid changes in the 25 Vβ families were evaluated using Spectratyping and data were presented as Hamming distance (HD). HD more than 20% was considered a change in TCR repertoire after HSCT. The mean HD was significantly changed after transplantation in all Vβ gene families, with most amino acid changes in p4 and p...
Source: Cancer Control - November 7, 2022 Category: Cancer & Oncology Authors: Fahimeh Zamani Reza Mirfakhraie Sayyed Reza Safaee Nodehi Yaghoub Mollaei-Kandelous Hossein Jafari Mohammad Farahmand Farhad Rezaei Majid Teymoori-Rad Abolfazl Movafagh Source Type: research
