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Supplementation with Bifidobacterium longum subspecies infantis EVC001 for mitigation of type 1 diabetes autoimmunity: the GPPAD-SINT1A randomised controlled trial protocol
Introduction The Global Platform for the Prevention of Autoimmune Diabetes-SINT1A Study is designed as a randomised, placebo-controlled, double-blind, multicentre, multinational, primary prevention study aiming to assess whether daily administration of Bifidobacterium infantis from age 7 days to 6 weeks until age 12 months to children with elevated genetic risk for type 1 diabetes reduces the cumulative incidence of beta-cell autoantibodies in childhood. Methods and analysis Infants aged 7 days to 6 weeks from Germany, Poland, Belgium, UK and Sweden are eligible for study participation if they have a >10.0% expected ri...
Source: BMJ Open - November 9, 2021 Category: General Medicine Authors: Ziegler, A.-G., Arnolds, S., Kölln, A., Achenbach, P., Berner, R., Bonifacio, E., Casteels, K., Elding Larsson, H., Gündert, M., Hasford, J., Kordonouri, O., Lundgren, M., Oltarzewski, M., Pekalski, M. L., Pfirrmann, M., Snape, M. D., Szyp Tags: Open access, Diabetes and Endocrinology Source Type: research

NIDCR's Spring 2021 E-Newsletter
Having trouble viewing this email? View it as a Web page. NIDCR's Spring 2021 E-Newsletter In this issue: NIDCR News Funding Opportunities & Related Notices NIH/HHS News Subscribe to NICDR News Science Advances   Grantee News   NIDCR News NIDCR & NIH Stand Against Structural Racism NIDCR Director Rena D’Souza, DDS, MS, PhD, said in a statement that there is no place for structural racism in biomedical research, echoing remarks from NIH Director Francis Collins, MD, PhD, in his announcement of a new NIH initiative—called UNIT...
Source: NIDCR Science News - April 7, 2021 Category: Dentistry Source Type: news

Clinical Applications of Interleukin-37: A Key Player in the Immunopathogenesis of Immune Disorders.
Abstract Recently, the era of medicine has been encountered with the exponential growth of special seroimmunobiomarkers in clinical trials. Lately, Interleukin-37 (IL-37) has attracted a wide range of basic medical scientists' attention due to its controversial functions in physiologic or pathologic microenvironments. In this research, an updated overview of immunobiological functions and clinical applications of IL-37 in a wide range of diseases, are discussed in order to highlight the role of recent laboratory-based results of IL-37. Data of this systematic review article were collected from initial 237 articles...
Source: Iranian Journal of Allergy, Asthma and Immunology - June 22, 2020 Category: Allergy & Immunology Authors: Khosh E, Bahmaie N, Elahi R, Esmaeilzadeh A Tags: Iran J Allergy Asthma Immunol Source Type: research

Traditional Chinese medicine (TCM)-what is myth and what is the state of evidence today?
Abstract Traditional Chinese medicine (TCM) is the most comprehensive and widely practiced system of medicine in the world.Originally, TCM appeared in our Western context as an unfathomable mythological doctrine. Once the linguistic barriers had been overcome, it became possible to understand and apply the terminological and physiological concepts, the method of diagnosis, and the clinical findings.Since the NIH consensus conference in 1998, our understanding of TCM has been the subject of methodologically robust studies. We now have evidence of the efficacy and effectiveness of acupuncture beyond its use in pain ...
Source: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz - April 6, 2020 Category: International Medicine & Public Health Authors: Hempen CH, Hummelsberger J Tags: Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz Source Type: research

Current Clinical Trials in Pemphigus and Pemphigoid
Conclusions The clinical trials discussed here, which include several trials investigating novel therapeutic targets, demonstrate that translational research in pemphigus and pemphigoid is a fast-growing field. We thus expect that several novel treatments will be shortly available for the treatment of pemphigus and pemphigoid patients. Given the high, and thus far unmet, medical need in this field (110), this is highly encouraging and will hopefully improve the quality of life of the affected patients. In addition to the compounds and targets described here, several new targets have been recently identified in preclinical...
Source: Frontiers in Immunology - May 2, 2019 Category: Allergy & Immunology Source Type: research

Neurological Involvement in Primary Systemic Vasculitis
Conclusion Neurological involvement is a common complication of PSV (Table 1), and neurologists play an important role in the identification and diagnosis of PSV patients with otherwise unexplained neurological symptoms as their chief complaint. This article summarizes the neurological manifestations of PSV and hopes to improve neuroscientists' understanding of this broad range of diseases. TABLE 1 Table 1. Common CNS and PNS involvements of primary systemic vasculitis. Author Contributions SZ conceived the article and wrote the manuscript. DY and GT reviewed and edited the manuscript. All authors ...
Source: Frontiers in Neurology - April 25, 2019 Category: Neurology Source Type: research

Report on the 2018 Cancer, Autoimmunity, and Immunology Conference.
Abstract With the increased use of cancer immunotherapy, a number of immune-related adverse events (irAEs) are being identified. These irAEs can be compared with known autoimmune disorders in similar tissues, with important similarities and differences. Understanding the etiology of irAEs may bring to light concepts applicable to immune responses in cancer, autoimmunity, and infectious disease. This immunobiology is especially relevant to cancer patients with preexisting allogeneic transplants or autoimmune disease who are undergoing cancer immunotherapy. To address these facets of cancer immunotherapy, academic l...
Source: Journal of Immunology - April 14, 2019 Category: Allergy & Immunology Authors: Curran CS, Sommers CL, Young HA, Bourcier K, Mancini M, Sharon E Tags: J Immunol Source Type: research

A Bidirectional Label Propagation Based Computational Model for Potential Microbe-Disease Association Prediction
Discussion There are numerous microbial communities inhabited in the human body, which is critical to human health. The relationship between human microbiome and diseases received much attention from both medical and bioinformatics community recently. However, traditional methods to detect their association is costly and labor-intensive. Thus, we proposed here a new computational model called NBLPIHMDA to infer potential microbe-disease associations. NBLPIHMDA first combined known microbe-disease associations in HMDAD and the Gaussian interaction profile kernel similarity to construct disease similarity network and microb...
Source: Frontiers in Microbiology - April 8, 2019 Category: Microbiology Source Type: research

Vitiligo: Focus on Clinical Aspects, Immunopathogenesis, and Therapy
AbstractVitiligo is an acquired chronic depigmenting disorder of the skin, with an estimated prevalence of 0.5% of the general population, characterized by the development of white macules resulting from a loss of epidermal melanocytes. The nomenclature has been revised after an extensive international work within the vitiligo global issues consensus conference, and vitiligo (formerly non-segmental vitiligo) is now a consensus umbrella term for all forms of generalized vitiligo. Two other subsets of vitiligo are segmental vitiligo and unclassified/undetermined vitiligo, which corresponds to focal disease and rare variants....
Source: Clinical Reviews in Allergy and Immunology - July 6, 2017 Category: Allergy & Immunology Source Type: research

Rationale and study design of the Adaptive study of IL-2 dose on regulatory T cells in type 1 diabetes (DILT1D): a non-randomised, open label, adaptive dose finding trial
Introduction CD4 T regulatory cells (Tregs) are crucial for the maintenance of self-tolerance and are deficient in many common autoimmune diseases such as type 1 diabetes (T1D). Interleukin 2 (IL-2) plays a major role in the activation and function of Tregs and treatment with ultra-low dose (ULD) IL-2 could increase Treg function to potentially halt disease progression in T1D. However, prior to embarking on large phase II/III clinical trials it is critical to develop new strategies for determining the mechanism of action of ULD IL-2 in participants with T1D. In this mechanistic study we will combine a novel trial design wi...
Source: BMJ Open - June 4, 2014 Category: Journals (General) Authors: Waldron-Lynch, F., Kareclas, P., Irons, K., Walker, N. M., Mander, A., Wicker, L. S., Todd, J. A., Bond, S. Tags: Open access, Immunology (including allergy), Pharmacology and therapeutics, Diabetes and Endocrinology Protocol Source Type: research