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Regulation of the epithelial Na+ channel by the mTORC2/SGK1 pathway
The epithelial Na+ channel (ENaC) is decisive for sodium reabsorption by the aldosterone-sensitive distal nephron (ASDN) of the kidney. ENaC is regulated by the serum- and glucocorticoid-inducible kinase 1 (SGK1), a kinase genomically upregulated by several hormones including glucocorticoids and mineralocorticoids. SGK1 is activated by the serine/threonine kinase mammalian target of rapamycin (mTOR) isoform mTORC2. SGK1 knockout (sgk1–/– mice) impairs renal Na+ retention during salt depletion. The mTOR catalytic site inhibitor, PP242, but not mTORC1 inhibitor rapamycin, inhibits ENaC, decreases Na+ flux in isol...
Source: Nephrology Dialysis Transplantation - January 25, 2016 Category: Urology & Nephrology Authors: Lang, F., Pearce, D. Tags: REVIEWS - BASIC SCIENCE AND TRANSLATIONAL NEPHROLOGY Source Type: research

Effectiveness of family involvement in newly diagnosed type 2 diabetes patients: a follow-up study
In recent years, the global prevalence of diabetes has increased significantly. The number of Chinese patients with type 2 diabetes mellitus (T2DM) ranks first in the world. Diabetes ranks in the third place among chronic non-communicable diseases according to the morbidity, disability and mortality as well as the degree of harm to human health, and it has brought a heavy burden on healthcare [1–3]. The family is an important place for people to influence lifestyle intervention of family members to participate may improve health and reduce disease relapse rate, increase well-being of the family, help improve diabetes, hy...
Source: Patient Education and Counseling - December 30, 2015 Category: Global & Universal Authors: Mai Shi, Mei-Yan Xu, Zhao-Lan Liu, Xue-Ying Duan, Yan-Bo Zhu, Hui-Mei Shi, Bo Jiang, Xiao-Mei Zhang, Xiao-Han Yu Source Type: research

The “Sapienza University Mortality and Morbidity Event Rate (SUMMER) Study in Diabetes”: Study Protocol
Discussion The “SUMMER study in diabetes” is aimed at identifying new molecular promoters of mortality and major vascular events in patients with T2DM. Most likely, these novel pathogenic factors will be instrumental for unraveling new pathways underlying such dramatic events. In addition, they will also be used as additional markers to increase the performance of already existing risk-scoring models in predicting the above mentioned outcomes in T2DM, as well as in setting up new preventive and treatment strategies, possibly tailored to specific pathogenic backgrounds.
Source: Nutrition, Metabolism and Cardiovascular Diseases - October 9, 2015 Category: Nutrition Source Type: research

Mortality following a cardiovascular or renal event in patients with type 2 diabetes in the ALTITUDE trial
Conclusion The majority of deaths occurred in patients who did not experience a non-fatal CV or renal event, although the risk of death was higher following an event. Our findings illustrate continuing opportunities to reduce morbidity and mortality in patients with type 2 diabetes.
Source: European Heart Journal - September 21, 2015 Category: Cardiology Authors: Jhund, P. S., McMurray, J. J. V., Chaturvedi, N., Brunel, P., Desai, A. S., Finn, P. V., Haffner, S. M., Solomon, S. D., Weinrauch, L. A., Claggett, B. L., Pfeffer, M. A. Tags: Prevention and epidemiology Source Type: research

Adiponectin predicts cardiovascular events in diabetes dialysis patients.
CONCLUSIONS: In diabetes dialysis patients low adiponectin favors occurrence of atherosclerosis related cardiovascular events. PMID: 26006757 [PubMed - as supplied by publisher]
Source: Clinical Biochemistry - May 22, 2015 Category: Biochemistry Authors: Kacso IM, Potra AR, Bondor CI, Moldovan D, Rusu C, Patiu IM, Racasan S, Orasan R, Vladutiu D, Spanu C, Rusu A, Nita C, Moldovan R, Ghigolea B, Kacso G Tags: Clin Biochem Source Type: research

Prospective study on the incidences of cardiovascular-renal complications in chinese patients with young-onset type 1 and type 2 diabetes.
CONCLUSIONS Young patients with type 2 diabetes had greater risks of developing cardiovascular-renal complications compared with patients with type 1 diabetes. The increased risk was driven primarily by accompanying metabolic risk factors. PMID: 24356598 [PubMed - in process]
Source: Diabetes Care - December 23, 2013 Category: Endocrinology Authors: Luk AO, Lau ES, So WY, Ma RC, Kong AP, Ozaki R, Chow FC, Chan JC Tags: Diabetes Care Source Type: research

Long-term Outcomes of Japanese Type 2 Diabetic Patients With Biopsy-Proven Diabetic Nephropathy.
CONCLUSIONSOur study suggests that the characteristic pathological lesions as well as macroalbuminuria (severe proteinuria) were closely related to the long-term outcomes of biopsy-proven diabetic nephropathy in type 2 diabetes. PMID: 24089538 [PubMed - as supplied by publisher]
Source: Diabetes Care - October 2, 2013 Category: Endocrinology Authors: Shimizu M, Furuichi K, Toyama T, Kitajima S, Hara A, Kitagawa K, Iwata Y, Sakai N, Takamura T, Yoshimura M, Yokoyama H, Kaneko S, Wada T, and the Kanazawa Study Group for Renal Diseases and Hypertension Tags: Diabetes Care Source Type: research

If you could propose one idea to help improve health care delivery in the United States, what would it be?
Thumbnail: Tags: conversationsphrma conversationslarry hausnermyrl weinbergchris hansennancy brownContributors: 11621161115911631173Contributions: Read Larry Hausner's bio Despite the rapid development of innovative technologies in the health care field, we have yet to discover a panacea that will easily transform our health care system into one that provides high-quality and cost-effective care.  What we have discovered and come to agree on over the last decade is that our sick care system must be reconfigured to a health care system that emphasizes wellness and prevention.  For that reason, I offer ...
Source: PHRMA - June 24, 2013 Category: Pharmaceuticals Authors: rlowe Source Type: news

Cardiovascular risk in women attending primary care centres: baseline data of the EVA study
Conclusions Four in 10 women attending primary care centres had a high or very high cardiovascular risk. Percentages of classic cardiovascular risk factors were higher in HT than in NHT and increased significantly with age. The most commonly used drugs were renin–angiotensin system blockers and diuretics.
Source: Nephrology Dialysis Transplantation - December 20, 2012 Category: Urology & Nephrology Authors: Fernandez-Vega, F., Prieto-Diaz, M. A., Redondo, M., Garcia-Norro, F. J., Suliman, N., Diaz, A., Vidal, C., Rodriguez, J. M., Montero, F. J., Gonzalez, M. B., Suarez, S., Garcia, J. J., Redondo, P. Tags: Original articles Source Type: research

Prevalence of hypertension and dyslipidemia and their associations with micro- and macrovascular diseases in patients with diabetes in Taiwan: An analysis of nationwide data for 2000-2009.
CONCLUSION: Although progressively increased prevalence of dyslipidemia and hypertension was observed in patients with diabetes in Taiwan, there was a decrease in the prevalence of stroke and CVD in the past 10 years. Among those with macrovascular diseases, except PVD, there was a trend of decreased prevalence of hypertension and dyslipidemia during the study period. In patients with microvascular diseases, prevalence of hypertension and dyslipidemia in patients with eye diseases increased in the past 10 years. More aggressive management of different risk factors is warranted in diabetic patients with various vascular dis...
Source: J Formos Med Assoc - November 1, 2012 Category: Journals (General) Authors: Tseng LN, Tseng YH, Jiang YD, Chang CH, Chung CH, Lin BJ, Chuang LM, Tai TY, Sheu WH Tags: J Formos Med Assoc Source Type: research

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