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Condition: Diabetes Type 2
Nutrition: Diets

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Total 290 results found since Jan 2013.

Use of a bioengineered antioxidant in mouse models of metabolic syndrome.
Conclusions: PEG-HCC can improve some parameters of disease in these models and this may be due to a resulting increase in peripheral insulin sensitivity. However, additional studies are needed to elucidate how PEG-HCCs are producing these effects. PMID: 31937152 [PubMed - as supplied by publisher]
Source: Expert Opinion on Investigational Drugs - January 17, 2020 Category: Drugs & Pharmacology Tags: Expert Opin Investig Drugs Source Type: research

Carbohydrate Quality, Glycemic Index, Glycemic Load and Cardiometabolic Risks in the US, Europe and Asia: A Dose-Response Meta-Analysis
ConclusionsOverweight/obese females can shift their carbohydrate intake for higher cereal fiber to decrease T2DM risk, but GL may cancel-out this effect.
Source: Nutrition, Metabolism and Cardiovascular Diseases - January 15, 2020 Category: Nutrition Source Type: research

Diet quality as a predictor of cardiometabolic disease-free life expectancy: the Whitehall II cohort study.
CONCLUSIONS: Healthier dietary habits are associated with cardiometabolic disease-free life expectancy between ages 50 and 85. PMID: 31927573 [PubMed - as supplied by publisher]
Source: The American Journal of Clinical Nutrition - January 10, 2020 Category: Nutrition Authors: Lagström H, Stenholm S, Akbaraly T, Pentti J, Vahtera J, Kivimäki M, Head J Tags: Am J Clin Nutr Source Type: research

Suboptimal Diet May Drive $50 Billion in Cardiometabolic Costs Suboptimal Diet May Drive $50 Billion in Cardiometabolic Costs
Poor diet is associated with 18.2% of all costs related to treatment of ischemic heart disease, stroke, and type 2 diabetes in the US, new research estimates.Medscape Medical News
Source: Medscape FamilyMedicine Headlines - December 31, 2019 Category: Primary Care Tags: Cardiology News Source Type: news

Unhealthy Eating Habits Cost U.S. $50 Billion a Year: Study
THURSDAY, Dec. 19, 2019 -- Healthier eating could save the United States more than $50 billion a year in health care costs associated with heart disease, stroke, type 2 diabetes and related illnesses, according to a new study. An unhealthy diet is...
Source: Drugs.com - Daily MedNews - December 19, 2019 Category: General Medicine Source Type: news

Cardiometabolic disease costs associated with suboptimal diet in the United States: A cost analysis based on a microsimulation model
ConclusionsSuboptimal diet of 10 dietary factors accounts for 18.2% of all ischemic heart disease, stroke, and type 2 diabetes costs in the US, highlighting that timely implementation of diet policies could address these health and economic burdens.
Source: PLoS Medicine - December 16, 2019 Category: Internal Medicine Authors: Thiago Veiga Jardim Source Type: research

Delayed Administration of Angiotensin II Type 2 Receptor (AT2R) Agonist Compound 21 Prevents the Development of Post-stroke Cognitive Impairment in Diabetes Through the Modulation of Microglia Polarization
AbstractA disabling consequence of stroke is cognitive impairment, occurring in 12% –48% of patients, for which there is no therapy. A critical barrier is the lack of understanding of how post-stroke cognitive impairment (PSCI) develops. While 70% of stroke victims present with comorbid diseases such as diabetes and hypertension, the limited use of comorbid disease models in prec linical research further contributes to this lack of progress. To this end, we used a translational model of diabetes to study the development of PSCI. In addition, we evaluated the application of compound 21 (C21), an angiotensin II Type 2 rece...
Source: Translational Stroke Research - December 2, 2019 Category: Neurology Source Type: research

Metformin for prevention or delay of type 2 diabetes mellitus and its associated complications in persons at increased risk for the development of type 2 diabetes mellitus.
CONCLUSIONS: Metformin compared with placebo or diet and exercise reduced or delayed the risk of T2DM in people at increased risk for the development of T2DM (moderate-quality evidence). However, metformin compared to intensive diet and exercise did not reduce or delay the risk of T2DM (moderate-quality evidence). Likewise, the combination of metformin and intensive diet and exercise compared to intensive diet and exercise only neither showed an advantage or disadvantage regarding the development of T2DM (very low-quality evidence). Data on patient-important outcomes such as mortality, macrovascular and microvascular diabe...
Source: Cochrane Database of Systematic Reviews - December 2, 2019 Category: General Medicine Authors: Madsen KS, Chi Y, Metzendorf MI, Richter B, Hemmingsen B Tags: Cochrane Database Syst Rev Source Type: research

How old am I really?
Telomeres are repetitive nucleotides sequences localized to the ends of each individual chromosome. They are replicated during each cellular division, but with each cell cycle they become progressively shorter. The problem is short telomeres are associated with dysregulation of cellular events such as senescence or cell death. The shortening process is accelerated by exposure to stress, smoking, obesity, lack of exercise, and poor diet. Many refer to this process as one of our “biological clocks.” In long-term studies, shortened telomeres are associated with adverse health outcomes including atherosclerosis, stroke, and Type 2 diabetes.
Source: The Journal of Pediatrics - November 22, 2019 Category: Pediatrics Authors: James F. Padbury Tags: The Editors' Perspectives Source Type: research

S-Homocysteinylation effects on transthyretin: Worsening of cardiomyopathy onset
ConclusionsOur study demonstrated that S-homocysteinylation of the L55P-TTR mutant impairs protein stability, favouring the appearance of toxic monomers. Interestingly, S-homocysteinylation affected only mutant, not wt-TTR. Moreover, we also show that assemblies of S-homocysteinylated L55P-TTR impair cardiomyocytes functional parameters.General significanceOur study offers new insights on the negative impact of S-homocysteinylation on L55P-TTR stability, whose aggregation is considered the causative agent of a form of early-onset familial amyloid polyneuropathy and cardiomyopathy. Our results suggest that high homocysteine...
Source: Biochimica et Biophysica Acta (BBA) General Subjects - October 29, 2019 Category: Biochemistry Source Type: research

Red and Processed Meat Consumption and Risk for All-Cause Mortality and Cardiometabolic Outcomes: A Systematic Review and Meta-analysis of Cohort Studies.
Conclusion: The magnitude of association between red and processed meat consumption and all-cause mortality and adverse cardiometabolic outcomes is very small, and the evidence is of low certainty. Primary Funding Source: None. (PROSPERO: CRD42017074074). PMID: 31569213 [PubMed - as supplied by publisher]
Source: Annals of Internal Medicine - September 30, 2019 Category: Internal Medicine Authors: Zeraatkar D, Han MA, Guyatt GH, Vernooij RWM, El Dib R, Cheung K, Milio K, Zworth M, Bartoszko JJ, Valli C, Rabassa M, Lee Y, Zajac J, Prokop-Dorner A, Lo C, Bala MM, Alonso-Coello P, Hanna SE, Johnston BC Tags: Ann Intern Med Source Type: research

AHA News: These Diets Helped Women With Diabetes Cut Heart Attack, Stroke Risk
THURSDAY, Sept. 19, 2019 (American Heart Association News) -- Eating patterns similar to the Mediterranean diet and the blood pressure-lowering DASH may help older women with Type 2 diabetes ward off heart attacks, strokes and related problems, new...
Source: Drugs.com - Daily MedNews - September 19, 2019 Category: General Medicine Source Type: news

Mediterranean diet: The role of long-chain ω-3 fatty acids in fish; polyphenols in fruits, vegetables, cereals, coffee, tea, cacao and wine; probiotics and vitamins in prevention of stroke, age-related cognitive decline, and Alzheimer disease.
Authors: Román GC, Jackson RE, Gadhia R, Román AN, Reis J Abstract The mechanisms of action of the dietary components of the Mediterranean diet are reviewed in prevention of cardiovascular disease, stroke, age-associated cognitive decline and Alzheimer disease. A companion article provides a comprehensive review of extra-virgin olive oil. The benefits of consumption of long-chain ω-3 fatty acids are described. Fresh fish provides eicosapentaenoic acid while α-linolenic acid is found in canola and soybean oils, purslane and nuts. These ω-3 fatty acids interact metabolically with ω-6 fatty acids mainly linoleic...
Source: Revue Neurologique - September 16, 2019 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Want To Live Longer? Study Suggests You Should Ditch Soda
This study, as well as other research on the connection between diet and sugary beverages and health risks, is observational and cannot show cause and effect. That’s a major limitation, researchers say, as it’s impossible to determine whether the association is due to a specific artificial sweetener, a type of beverage, obesity or another hidden health issue. “The cause behind these associations isn’t clear,” said Bergquist. “Other potential biological causes could be attributed to experimental evidence linking consumption of artificial sweeteners to sugar cravings, appetite stimulation ...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - September 3, 2019 Category: Consumer Health News Authors: Health – CBS Boston Tags: Health News CNN Soda Source Type: news