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Condition: Autism
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Total 234 results found since Jan 2013.
The Promoter Regions of Intellectual Disability-Associated Genes Are Uniquely Enriched in LTR Sequences of the MER41 Primate-Specific Endogenous Retrovirus: An Evolutionary Connection Between Immunity and Cognition
Discussion
We have found that, in the human genome, the promoter regions of ID-associated genes are uniquely enriched in MER41 LTRs. More specifically, nine ID-associated genes that are putatively important in cognitive evolution exhibit MER41 LTRs in their promoter regions. As more than 100 families of HERV are integrated into our genome, it was important to determine whether our findings are specific to MER41 and to ID-associated genes, and if so to what extent. Among the 133 families of HERV explored here, MER41 is the only family whose LTRs were found with statistically high frequency in the promoter regions of ID-ass...
Source: Frontiers in Genetics - April 11, 2019 Category: Genetics & Stem Cells Source Type: research
Targeting damages in the brain: Exosomes derived from MSC present migration and homing abilities to different neurodegenerative and neuropsychiatric locations
ConclusionWe used gold nanoparticles loaded exosomes for in-vivo neuroimaging and present specific migration and homing to various brain pathologies including stroke, Parkinson's, Alzheimer's, Autism and healthy brains as a control. By this method, we visualized the migration and homing abilities of exosomes in long-term follow-up ad report that in pathological areas they home for more than 96 hours while in healthy brains they are being evacuated within 24 hours. Furthermore, we show that MSC-exo uses chemotaxis signaling to target the inflammatory areas in the brain.
Source: Cytotherapy - May 24, 2019 Category: Cytology Source Type: research
An umbrella review of the evidence for equine ‐assisted interventions
ConclusionsThe evidence for equine ‐assisted interventions for adults and children across a range of conditions and presentations is equivocal. The current evidence base is marred by multiple methodological weaknesses and thus, therapeutic interventions that include a horse cannot be asserted as best practice at this time. Rigorous research is indicated to determine the utility of equine‐assisted interventions.
Source: Australian Journal of Psychology - February 19, 2019 Category: Psychiatry & Psychology Authors: Cindy Stern,
Anna Chur ‐Hansen Tags: SPECIAL ISSUE Source Type: research
Consensus Paper: Experimental Neurostimulation of the Cerebellum
We report on the most advanced techniques for manipulating cerebellar circuits in humans and animal models and define key hurdles and questions for moving forward.
Source: The Cerebellum - June 3, 2019 Category: Neurology Source Type: research
Consensus Paper: Experimental Neurostimulation of the Cerebellum.
We report on the most advanced techniques for manipulating cerebellar circuits in humans and animal models and define key hurdles and questions for moving forward.
PMID: 31165428 [PubMed - as supplied by publisher]
Source: Cerebellum - June 3, 2019 Category: Neuroscience Authors: Miterko LN, Baker KB, Beckinghausen J, Bradnam LV, Cheng MY, Cooperrider J, DeLong MR, Gornati SV, Hallett M, Heck DH, Hoebeek FE, Kouzani AZ, Kuo SH, Louis ED, Machado A, Manto M, McCambridge AB, Nitsche MA, Taib NOB, Popa T, Tanaka M, Timmann D, Steinbe Tags: Cerebellum Source Type: research
Benefits of curcumin in brain disorders
AbstractCurcumin is widely consumed in Asia either as turmeric directly or as one of the culinary ingredients in food recipes. The benefits of curcumin in different organ systems have been reported extensively in several neurological diseases and cancer. Curcumin has got its global recognition because of its strong antioxidant, anti ‐inflammatory, anti‐cancer, and antimicrobial activities. Additionally, it is used in diabetes and arthritis as well as in hepatic, renal, and cardiovascular diseases. Recently, there is growing attention on usage of curcumin to prevent or delay the onset of neurodegenerative diseases. This...
Source: BioFactors - June 10, 2019 Category: Biochemistry Authors: Abid Bhat,
Arehally M. Mahalakshmi,
Bipul Ray,
Sunanda Tuladhar,
Tousif A. Hediyal,
Esther Manthiannem,
Jagadeeswari Padamati,
Ramesh Chandra,
Saravana B. Chidambaram,
Meena K. Sakharkar Tags: REVIEW ARTICLE Source Type: research
An umbrella review of the evidence for equine ‐assisted interventions
ConclusionsThe evidence for equine ‐assisted interventions for adults and children across a range of conditions and presentations is equivocal. The current evidence base is marred by multiple methodological weaknesses and thus, therapeutic interventions that include a horse cannot be asserted as best practice at this time. Rigorous research is indicated to determine the utility of equine‐assisted interventions.
Source: Australian Journal of Psychology - February 19, 2019 Category: Psychiatry & Psychology Authors: Cindy Stern,
Anna Chur ‐Hansen Tags: SPECIAL ISSUE Source Type: research
Application of functional near-infrared spectroscopy in the healthcare industry: A review
This study comprehensively reviews brain-impaired patients: The studies involving patient populations and the diseases discussed in more than 10 works are included. Eleven diseases examined in this paper include autism spectrum disorder, attention-deficit hyperactivity disorder, epilepsy, depressive disorders, anxiety and panic disorder, schizophrenia, mild cognitive impairment, Alzheimer ’s disease, Parkinson’s disease, stroke, and traumatic brain injury. For each disease, the tasks used for examination, fNIRS variables, and significant findings on the impairment are discussed. The channel configurations and the regio...
Source: Journal of Innovative Optical Health Sciences - September 11, 2019 Category: Biomedical Science Authors: Keum-Shik Hong M. Atif Yaqub Source Type: research
The Director of the NIH Lays Out His Vision of the Future of Medical Science
Our world has never witnessed a time of greater promise for improving human health. Many of today’s health advances have stemmed from a long arc of discovery that begins with strong, steady support for basic science. In large part because of fundamental research funded by the National Institutes of Health (NIH), which traces its roots to 1887, Americans are living longer, healthier lives. Life expectancy for a baby born in the U.S. has risen from 47 years in 1900 to more than 78 years today. Among the advances that have helped to make this possible are a 70% decline in the U.S. death rate from cardiovascular disease ...
Source: TIME: Science - October 24, 2019 Category: Science Authors: Dr. Francis S. Collins Tags: Uncategorized Healthcare medicine Source Type: news
Cognoa, MedRhythms announce pivotal trials in preparation for FDA submissions
Cognoa and MedRhythms will be kicking off multi-site investigations of their tools, which are designed for pediatric autism diagnosis and stroke rehabilitation, respectively.
Source: mobihealthnews - October 28, 2019 Category: Information Technology Source Type: news
Transcranial Magnetic Stimulation for the Treatment of Pediatric Neurological Disorders
AbstractPurpose of reviewRepetitive transcranial magnetic stimulation (rTMS) is a form of noninvasive brain stimulation that is used for the treatment of migraine and major depression in adults and is now being evaluated for use in other disorders. The purpose of this review is to summarize the physiology underlying TMS, the safety and tolerability in pediatric patients, and the evidence for TMS efficacy in the treatment of pediatric neurologic disorders.Recent findingsStudies investigating rTMS for adolescent depression, hemiparesis due to pediatric stroke, autism, and tics/Tourette syndrome have demonstrated some therape...
Source: Current Treatment Options in Neurology - November 12, 2019 Category: Neurology Source Type: research
The gut microbiome in neurological disorders
Publication date: Available online 18 November 2019Source: The Lancet NeurologyAuthor(s): John F Cryan, Kenneth J O'Riordan, Kiran Sandhu, Veronica Peterson, Timothy G DinanSummaryResearch into the role of the gut microbiome in modulating brain function has rapidly increased over the past 10 years, albeit chiefly in animal models. Increasing clinical and preclinical evidence implicates the microbiome as a possible key susceptibility factor for neurological disorders, including Alzheimer's disease, autism spectrum disorder, multiple sclerosis, Parkinson's disease, and stroke. Cross-sectional clinical studies are bolstering ...
Source: The Lancet Neurology - November 19, 2019 Category: Neurology Source Type: research
'Face blindness' may involve a failed brain network, and could shed light on autism
(Boston Children's Hospital) Face blindness often becomes apparent in early childhood, but people occasionally acquire it from a brain injury later in life. A new study of people who became face-blind after a stroke, led by Alexander Cohen, MD, PhD, of Boston Children's Hospital, provides clues to what goes wrong in the brain.
Source: EurekAlert! - Medicine and Health - November 19, 2019 Category: International Medicine & Public Health Source Type: news
Psychostimulants/Atomoxetine and Serious Cardiovascular Events in Children with ADHD or Autism Spectrum Disorder
ConclusionUsing large US claims data, we found no evidence of increased SCV risk in children and adolescents with ADHD or ASD exposed to ADHD medications.
Source: CNS Drugs - November 24, 2019 Category: Neurology Source Type: research
