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Prevalence and Risk Factors of Caregiver Dependence among Older Adults in a Southeast Asian Population.
CONCLUSION: Various sociodemographic and health-related conditions were significantly associated with caregiver dependence. Dependent older adults will put greater demands on health and social services, resulting in greater healthcare expenditures. Hence, effective planning, services and support are crucial to meet the needs of dependent older adults and their caregivers.
PMID: 27922142 [PubMed - in process]
Source: Annals of the Academy of Medicine, Singapore - October 31, 2016 Category: Journals (General) Authors: Picco L, Abdin E, Vaingankar JA, Pang S, Shafie S, Sambasivam R, Chong SA, Subramaniam M Tags: Ann Acad Med Singapore Source Type: research
Effects of bidi smoking on all-cause mortality and cardiorespiratory outcomes in men from south Asia: an observational community-based substudy of the Prospective Urban Rural Epidemiology Study (PURE)
We examined the effects of bidi smoking on baseline respiratory impairment, and prospectively collected data for all-cause mortality and cardiorespiratory events in men from this region. Methods This substudy of the international, community-based Prospective Urban Rural Epidemiology (PURE) study was done in seven centres in India, Pakistan, and Bangladesh. Men aged 35–70 years completed spirometry testing and standardised questionnaires at baseline and were followed up yearly. We used multilevel regression to compare cross-sectional baseline cardiorespiratory symptoms, spirometry measurements, and follow-up events (all-c...
Source: The Lancet Global Health - January 16, 2017 Category: Global & Universal Source Type: research
The therapeutic potential of purinergic signalling.
Abstract
This review is focused on the pathophysiology and therapeutic potential of purinergic signalling. A wide range of diseases are considered, including those of the central nervous system, skin, kidney, musculoskeletal, liver gut, lower urinary tract, cardiovascular, airways and reproductive systems, the special senses, infection, diabetes and obesity. Several purinergic drugs are already on the market, including P2Y12 receptor antagonists for stroke and thrombosis, P2Y2 receptor agonists for dry eye, A1 receptor agonists for supraventricular tachycardia. Clinical trials are underway for the use of P2X3 rece...
Source: Biochemical Pharmacology - July 20, 2017 Category: Drugs & Pharmacology Authors: Burnstock G Tags: Biochem Pharmacol Source Type: research
Comparison of clinical features and outcome in COPD patients with and without heart failure, admitted at tertiary care hospital
Conclusion: COPD with HF most likely presented with breathlessness and cough, with longer hospital stay and were more prone to arrhythmias as compared to COPD without HF.
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Ashraf, S., Ashraf, A. Tags: Monitoring Airway Disease Source Type: research
Comparison of a portable device versus a specific spirometer for cough flow testing
Conclusions: In this evaluation, including patients with heterogeneous disorders and normal controls, CPF readings were on average significantly higher when measured using the equipment with the CPF testing dedicated software; moreover this device allows for a better assessment of the cough maneuvers including visualization of the cough flow-volume loops.
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Maia Silva, A., Viamonte, S., Machado Vaz, I., Almeida, M., Gomes, A., Silva, F., Winck, J. C. Tags: Monitoring Airway Disease Source Type: research
The double-sidedness of cough in the elderly
Publication date: Available online 11 January 2018 Source:Respiratory Physiology & Neurobiology Author(s): Ha-Kyeong Won, Sol-Ji Yoon, Woo-Jung Song Cough is a physiological reflex to protect airways against aspiration, but also it is one of the most frequent problems that lead patients to seek medical care. Chronic cough is more prevalent in the elderly than younger subjects, and more challenging to manage due to frequent comorbidities and possible side effects from drug treatment. Meanwhile, cough reflex does not decrease with natural aging but is often impaired by pathologic conditions like stroke. The impairme...
Source: Respiratory Physiology and Neurobiology - January 12, 2018 Category: Respiratory Medicine Source Type: research
New treatment for SMA offers hope for Arianna
For the first few months of Arianna Condon’s life, everything was moving along fine. She was a happy baby, and seemed to be developing much like her older sister, Tessa.
“She was gaining weight, and seemed to be doing great,” says Arianna’s mom, Marina. “She did have problems with reflux, but it was nothing too unusual for a baby.”
But by the time Arianna was 3 months old, Marina started to have concerns. Arianna wasn’t lifting her head the way Tessa had at that age. Something didn’t seem right.
“I brought it up to her pediatrician, but she told me that all babies develop differently and there wasn’t a ...
Source: Thrive, Children's Hospital Boston - January 16, 2018 Category: Pediatrics Authors: Ellen Greenlaw Tags: Diseases & Conditions Our Patients’ Stories Dr. Basil Darras spinal muscular atrophy spinal muscular atrophy program Spinraza Source Type: news
IJERPH, Vol. 15, Pages 252: Residents ’ Self-Reported Health Effects and Annoyance in Relation to Air Pollution Exposure in an Industrial Area in Eastern-Estonia
IJERPH, Vol. 15, Pages 252: Residents’ Self-Reported Health Effects and Annoyance in Relation to Air Pollution Exposure in an Industrial Area in Eastern-Estonia
International Journal of Environmental Research and Public Health doi: 10.3390/ijerph15020252
Authors:
Hans Orru
Jane Idavain
Mihkel Pindus
Kati Orru
Kaisa Kesanurm
Aavo Lang
Jelena Tomasova
Eastern Estonia has large oil shale mines and industrial facilities mainly focused on electricity generation from oil shale and shale oil extraction, which produce high air pollution emissions. The “Study of the health impact of the oil shale sector—SO...
Source: International Journal of Environmental Research and Public Health - February 2, 2018 Category: Environmental Health Authors: Hans Orru Jane Idavain Mihkel Pindus Kati Orru Kaisa Kesanurm Aavo Lang Jelena Tomasova Tags: Article Source Type: research
Cough response to aspiration in thin and thick fluids during FEES in hospitalized inpatients.
CONCLUSIONS & IMPLICATIONS: Cough response to aspiration differs across bolus volumes and viscosities. The finding of inconsistent cough response to aspiration in some patients strongly encourages the use of instrumental assessment to guide decisions regarding diet modifications.
PMID: 29845700 [PubMed - as supplied by publisher]
Source: International Journal of Language and Communication Disorders - May 30, 2018 Category: Speech-Language Pathology Authors: Miles A, McFarlane M, Scott S, Hunting A Tags: Int J Lang Commun Disord Source Type: research
A True Hematologic Emergency
BY GREGORY TAYLOR, DO, & JACKLYN MCPARLANE, DOA 33-year-old woman with a past medical history of sickle cell SS presented to the emergency department with chest pain, difficulty breathing, and a cough for two days. Her chest pain was diffuse, without radiation, and partially reproducible. Her cough was nonproductive, and she also reported fever and chills.The patient noted this was different from her normal back and leg pain from past sickle cell crises. She was following up with a sickle cell specialist, and was compliant with her hydroxyurea treatment.Her temperature was 102.8°F, blood pressure was 94/60 mm...
Source: The Case Files - June 26, 2018 Category: Emergency Medicine Tags: Blog Posts Source Type: research
The double-sidedness of cough in the elderly
Publication date: Available online 11 January 2018Source: Respiratory Physiology & NeurobiologyAuthor(s): Ha-Kyeong Won, Sol-Ji Yoon, Woo-Jung SongAbstractCough is a physiological reflex to protect airways against aspiration, but also it is one of the most frequent problems that lead patients to seek medical care. Chronic cough is more prevalent in the elderly than younger subjects, and more challenging to manage due to frequent comorbidities and possible side effects from drug treatment. Meanwhile, cough reflex does not decrease with natural aging but is often impaired by pathologic conditions like stroke. The impairment ...
Source: Respiratory Physiology and Neurobiology - July 5, 2018 Category: Respiratory Medicine Source Type: research
A Study on Etiopathogenesis of Vocal Cord Paresis and Palsy in a Tertiary Centre
AbstractTo identify patients of vocal cord paresis and palsy and to establish an etiological diagnosis based on a study performed in a tertiary centre. Study was done prospectively in the Department of ENT in KIMS Hospital, Bangalore, for 1 year, from June 2016 to June 2017. 100 patients with vocal cord paresis and palsy were identified and examined by using various tests and investigations to establish the etiology. Most of the patients presented with complaints of change in voice (92%). Some of the other common presenting complaint s included noisy breathing and difficulty in swallowing, difficulty in voice production ...
Source: Indian Journal of Otolaryngology and Head and Neck Surgery - October 8, 2018 Category: ENT & OMF Source Type: research
Effectiveness of polypill for primary and secondary prevention of cardiovascular diseases (PolyIran): a pragmatic, cluster-randomised trial
Publication date: 24–30 August 2019Source: The Lancet, Volume 394, Issue 10199Author(s): Gholamreza Roshandel, Masoud Khoshnia, Hossein Poustchi, Karla Hemming, Farin Kamangar, Abdolsamad Gharavi, Mohammad Reza Ostovaneh, Alireza Nateghi, Masoud Majed, Behrooz Navabakhsh, Shahin Merat, Akram Pourshams, Mahdi Nalini, Fatemeh Malekzadeh, Masoumeh Sadeghi, Noushin Mohammadifard, Nizal Sarrafzadegan, Mohammad Naemi-Tabiei, Abdolreza Fazel, Paul BrennanSummaryBackgroundA fixed-dose combination therapy (polypill strategy) has been proposed as an approach to reduce the burden of cardiovascular disease, especially in low-income ...
Source: The Lancet - August 23, 2019 Category: General Medicine Source Type: research
Introduction to Purinergic Signaling.
Abstract
Purinergic signaling was proposed in 1972, after it was demonstrated that adenosine 5'-triphosphate (ATP) was a transmitter in nonadrenergic, noncholinergic inhibitory nerves supplying the guinea-pig taenia coli. Later, ATP was identified as an excitatory cotransmitter in sympathetic and parasympathetic nerves, and it is now apparent that ATP acts as a cotransmitter in most, if not all, nerves in both the peripheral nervous system and central nervous system (CNS). ATP acts as a short-term signaling molecule in neurotransmission, neuromodulation, and neurosecretion. It also has potent, long-term (trophic) ...
Source: Mol Biol Cell - October 27, 2019 Category: Molecular Biology Authors: Burnstock G Tags: Methods Mol Biol Source Type: research
