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Condition: Asthma
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Total 404 results found since Jan 2013.
CTNNAL1 participates in the regulation of mucus overproduction in HDM-induced asthma mouse model through the YAP-ROCK2 pathway
J Cell Mol Med. 2022 Jan 28. doi: 10.1111/jcmm.17206. Online ahead of print.ABSTRACTOur previous study indicated that adhesion molecule catenin alpha-like 1(CTNNAL1) is downregulated in airway epithelial cells of asthma patients and asthma animal model but little is known about how the CTNNAL1 affects asthma pathogenesis. To reveal the direct relationship between asthma and CTNNAL1, CTNNAL1-deficient mouse model in bronchopulmonary tissue was constructed by introducing CTNNAL1-siRNA sequence using adeno-associated virus (AAV) as vector. The mouse model of asthma was established by stimulation of house dust mite (HDM). Afte...
Source: Molecular Medicine - January 29, 2022 Category: Molecular Biology Authors: Di Wu Wang Jiang Caixia Liu Lexin Liu Furong Li Xiaodi Ma Lang Pan Chi Liu Xiangping Qu Huijun Liu Xiaoqun Qin Yang Xiang Source Type: research
Effect of Src tyrosine kinase on a rat model of asthma
In conclusion, the present study utilized a gene transfer technique to interfere with the expression of Src in rats, which decreased the levels of IL-5, IL-33, WBCs and EOSs and increased the level of IFN-γ; these changes effectively ameliorated the condition of the trachea in asthmatic rats.PMID:35069853 | PMC:PMC8764580 | DOI:10.3892/etm.2021.11095
Source: Experimental and Therapeutic Medicine - January 24, 2022 Category: General Medicine Authors: Min Wu Jingping Yang Tao Liu Pengfei Xuan Baoying Bu Xiyuan Xu Rina Wu Source Type: research
Small Proline-Rich Protein 3 Regulates IL-33/ILC2 Axis to Promote Allergic Airway Inflammation
This study reveals the regulatory role of SPRR3 in allergic airway inflammation, identifying this protein as a potential novel therapeutic target for asthma.
Source: Frontiers in Immunology - January 20, 2022 Category: Allergy & Immunology Source Type: research
15LO1 dictates glutathione redox changes in asthmatic airway epithelium to worsen type 2 inflammation
Altered redox biology challenges all cells, with compensatory responses often determining a cell’s fate. When 15 lipoxygenase 1 (15LO1), a lipid-peroxidizing enzyme abundant in asthmatic human airway epithelial cells (HAECs), binds phosphatidylethanolamine-binding protein 1 (PEBP1), hydroperoxy-phospholipids, which drive ferroptotic cell death, are generated. Peroxidases, including glutathione peroxidase 4 (GPX4), metabolize hydroperoxy-phospholipids to hydroxy derivatives to prevent ferroptotic death, but consume reduced glutathione (GSH). The cystine transporter SLC7A11 critically restores/maintains intracellular GSH. ...
Source: Journal of Clinical Investigation - January 16, 2022 Category: Biomedical Science Authors: Tadao Nagasaki, Alexander J. Schuyler, Jinming Zhao, Svetlana N. Samovich, Kazuhiro Yamada, Yanhan Deng, Scott P. Ginebaugh, Stephanie A. Christenson, Prescott G. Woodruff, John V. Fahy, John B. Trudeau, Detcho Stoyanovsky, Anuradha Ray, Yulia Y. Tyurina, Source Type: research
Leukotriene C < sub > 4 < /sub > synthase is a novel PPAR γ target gene, and leukotriene C < sub > 4 < /sub > and D < sub > 4 < /sub > activate adipogenesis through cysteinyl LT1 receptors in adipocytes
In this study, we investigated the expression of LTC4S and production of CysLTs in murine adipocyte 3T3-L1 cells and their underlying regulatory mechanisms. Expression of LTC4S and production of LTC4 and CysLTs increased during adipogenesis, whereas siRNA-mediated suppression of LTC4S expression repressed adipogenesis by reducing adipogenic gene expression. The CysLT1 receptor, one of the two LTC4 receptors, was expressed in adipocytes. LTC4 and LTD4 increased the intracellular triglyceride levels and adipogenic gene expression, and their enhancement was suppressed by co-treatment with pranlukast, a CysLT1 receptor antagon...
Source: Biochimica et Biophysica Acta - December 30, 2021 Category: Biochemistry Authors: Ko Fujimori Saki Uno Kyohei Kuroda Chihiro Matsumoto Toko Maehara Source Type: research
The mixture of siRNAs targeted to IL-4 and IL-13 genes effectively reduces the airway hyperreactivity and allergic inflammation in a mouse model of asthma
In this study we evaluated whether the siRNA targeted to IL-4 and IL-13 reduce BA symptoms in mice model. Experimental BA was induced in BALB/c mice by sensitization to ovalbumin allergen followed by intranasal challenge. The intranasal delivery of siRNAs targeted to IL-4 and IL-13 inhibited the lung expression of these cytokines by more than 50% that led to the attenuation of AHR and pulmonary inflammation; the quantity of eosinophils in lungs which are one of the major inflammatory cells involved in allergic asthma pathogenesis decreased by more than 50% after siRNA treatment. These data support the possibility of a dual...
Source: International Immunopharmacology - December 19, 2021 Category: Allergy & Immunology Authors: Shilovskiy Ip Sundukova Ms Korneev Av Nikolskii Aa Barvinskaya Ed Kovchina Vi Vishniakova Li Turenko Vn Yumashev Kv Kaganova Mm Brylina Ve Sergeev I Maerle A Kudlay DA Petukhova O Khaitov M R Source Type: research
LSC - 2021 - COL4A3 expression in asthmatic epithelium depends on intronic methylation and ZNF263 binding
Conclusion: Our data suggests an epigenetic modification at cg11797365 interrupts ZNF263 binding which may contribute to the COL4A3 expression deficit in asthmatic airways.
Source: European Respiratory Journal - November 25, 2021 Category: Respiratory Medicine Authors: Sai Sneha Priya, N., Joseph Vermeulen, C., Pech, M., Faiz, A., George G. Oliver, B., Van Den Berge, M., Kay Burgess, J., Kopp, M., Weckmann, M. Tags: Occupational and environmental health Source Type: research
