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Comprehensive care of adults with respiratory diseases must include vaccines
Vaccines are among the most effective tools we have to improve and save lives, but only if they are administered to eligible patients. In this issue, Naeger et al1 highlight the major opportunities that the health care community has to achieve high adult vaccination rates. These vaccines include those for prevention of coronavirus disease 2019 (COVID-19), pneumococcal, and influenza, diseases that respiratory health professionals are most aware of, plus pertussis (in Tdap), herpes zoster (HZ, shingles), and as of May 3, 2023, respiratory syncytial viral, for which adults with asthma and chronic obstructive pulmonary diseas...
Source: Annals of Allergy, Asthma and Immunology - September 1, 2023 Category: Allergy & Immunology Authors: Barbara P. Yawn, Dennis Williams, Gregory Poland Tags: Editorial Source Type: research

The Human Upper Respiratory Tract Epithelium Is Susceptible to Flaviviruses
In this study, we exposed apically well-differentiated human NECs cultured at the ALI to the related flaviviruses ZIKV, JEV, WNV, and Usutu virus (USUV). We selected these viruses due to the recent increasing evidences of potential threat to humans (Cadar et al., 2017; Simonin et al., 2018). We show that NECs are particularly susceptible to JEV and WNV infection and to other flaviviruses included in this study. Infection with each virus led to shedding of infectious virus particles through the apical and basolateral surfaces and triggered host mechanisms at the level of inflammatory and antiviral mediators....
Source: Frontiers in Microbiology - April 15, 2019 Category: Microbiology Source Type: research

A 58-Year-Old Woman With Pneumonia and Gram-Negative Diplococci.
Abstract CASE PRESENTATION: A 58-year-old woman with COPD, cor pulmonale, diabetes, and hypertension had a productive cough of greenish and purulent sputum, low-grade fever, and shortness of breath. Medications were metformin, losartan, cholecalciferol, folic acid, a multivitamin, fluticasone by inhalation, and, as needed, ipratropium by inhalation. She lived alone and worked as a physician, had received that year's seasonal influenza vaccine, was a heavy smoker, did not drink alcohol or use illicit drugs, and had no personal or family history of allergy and autoimmunity. PMID: 28991556 [PubMed - in process]
Source: Chest - October 1, 2017 Category: Respiratory Medicine Authors: Famularo G, Sordillo P, Stasolla A, Parisi MG Tags: Chest Source Type: research

Impaired Humoral and Cellular Immune Responses to Influenza Vaccination in COPD Patient
Source: Journal of Allergy and Clinical Immunology - September 7, 2017 Category: Allergy & Immunology Authors: Aur élien Parpaleix, Laurent Boyer, Aurelie Wiedemann, Christine Lacabaratz, Laurent Margarit, Vincent Enouf, Philippe Le Corvoisier, Anne Lino, Ala Covali-Noroc, Bruno Housset, Christos Chouaid, Bernard Maitre, Yves Lévy, Jean-Daniel Lelièvre, Serge A Source Type: research

Impaired humoral and cellular immune responses to influenza vaccination in chronic obstructive pulmonary disease patients
Exacerbations are the main sources of hospitalization and mortality in patients with chronic obstructive pulmonary disease (COPD). They are related chiefly to lung infections,1 of which 36% are due to influenza viruses.2,3 Exacerbations triggered by viral infections are usually more severe than those related to bacterial infections, with a longer recovery time and a higher admission rate.1 Although influenza vaccination of patients with COPD is recommended in many countries, the immune response to the vaccine in this population has not been studied in detail.
Source: Journal of Allergy and Clinical Immunology - September 7, 2017 Category: Allergy & Immunology Authors: Aur élien Parpaleix, Laurent Boyer, Aurelie Wiedemann, Christine Lacabaratz, Laurent Margarit, Vincent Enouf, Philippe Le Corvoisier, Anne Lino, Ala Covali-Noroc, Bruno Housset, Christos Chouaid, Bernard Maitre, Yves Lévy, Jean-Daniel Lelièvre, Serge A Tags: Letter to the Editor Source Type: research

How Common is α -1-Antitrypsin Deficiency?
Discussion α-1-Antitrypsin Deficiency (A1AT) is a common single-gene mutation disease that is homozygous recessive. The normal allele is called M and the most common abnormal allele is Z. There are other alleles though. The gene codes for one of the primary protease inhibitors in the serum, thus those who are homozygous for the Z gene are sometimes referred to as “PIZZ” or “PIZ.” α-1-Antitrypsin is found in all body tissues but is especially important in the serum and lung. As noted it is one of the primary neutrophil protease inhibitors in the serum, and acts to neutralize these enzymes...
Source: PediatricEducation.org - April 24, 2017 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

Vaccines for Patients with COPD.
This article presents a brief overview of the different studies found, on the new patents, and the future strategies on the field. PMID: 25706527 [PubMed - in process]
Source: Recent Patents on Inflammation and Allergy Drug Discovery - June 4, 2015 Category: Allergy & Immunology Tags: Recent Pat Inflamm Allergy Drug Discov Source Type: research

Uh Oh, It's Flu Season! What You Need to Know About Flu Vaccination
Media reports from just about every corner of the country are cautioning that Americans could be in for a particularly intense flu season this year, with many medical experts encouraging folks not to delay getting their flu shots. The flu season is not only here -- it could last until as late as May of next year according to the CDC. With this in mind, it is helpful to review a few basics that could help keep you, your family and your friends and neighbors feeling at their best during this winter's seasonal outbreaks of the flu. Who's at Risk? The flu is a respiratory infection that can cause serious, sometimes life-thr...
Source: Healthy Living - The Huffington Post - December 12, 2014 Category: Consumer Health News Source Type: news

What Are the Basic Oxygen Delivery Methods?
Discussion Oxygen is the most common element on earth. It makes up 21% of air, 89% of seawater and 46% of the earth’s crust. It is a highly reactive element (including being highly flammable) that must be combined to be stable (O2 molecular form) and non-reactive at ambient temperature and pressure. A continuous supply of oxygen is necessary for human life and lack of oxygen leads to hypoxic brain damage and other end organ damage such as the liver, kidneys and heart. Thus in hypoxic situations, emergency oxygen use is necessary. Situations where O2 is necessary in high concentrations includes major trauma, shock, ...
Source: PediatricEducation.org - April 29, 2013 Category: Pediatrics Authors: Donna M. D'Alessandro, M.D. Tags: Uncategorized Source Type: news

Tako-Tsubo cardiomyopathy after influenza vaccination
A 78-year-old man with hypertension, diabetes, chronic obstructive pulmonary disease, chronic kidney disease and history of allergy to cephalosporine, was admitted with chest pain and dyspnea, which appeared three days after administration of anti-influenza vaccine (Fluad® Novartis, a single dose of 0.50ml i.m.; containing an A/California/7/2009 (H1N1)pdm09-like virus 15μg (HA), an A/Victoria/361/2011 (H3N2)-like virus 15μg (HA), a B/Wisconsin/1/2010-like virus 15μg (HA)).
Source: International Journal of Cardiology - April 22, 2013 Category: Cardiology Authors: Francesco Santoro, Riccardo Ieva, Armando Ferraretti, Giuseppe Carpagnano, Ilaria Pappalardo, Luisa De Gennaro, Matteo Di Biase, Natale Daniele Brunetti Tags: Online letters to the editor Source Type: research