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Condition: Chronic Obstructive Pulmonary
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Total 17 results found since Jan 2013.
Classifying asthma control using salivary and fecal microbiome in children with moderate to severe asthma: results from the SysPharmPediA study
Conclusions: Controlled and uncontrolled asthmatics could be differentiated in children based on their microbiome using machine learning, suggesting a link between asthma control and the microbiome. This suggests that the microbiome may be a potential target for a precision medicine approach to improve asthma control in children.
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Blankestijn, J., Lopez-Rincon, A., Neerincx, A. H., Vijverberg, S. J., Hashimoto, S., Gorenjak, M., Sardon-Prado, O., Corcuera, P., Korta-Murua, J., Pino-Yanes, M., Potocnik, U., Wolff, C., Brandstetter, S., Toncheva, A. A., Kheiroddin, P., Harner, S., Ka Tags: 07.02 - Paediatric asthma and allergy Source Type: research
Differentiating COPD and asthma using quantitative CT imaging and machine learning
Conclusion
COPD and asthma can be differentiated using machine learning with moderate-to-high accuracy by a subset of only seven CT features.
Source: European Respiratory Journal - September 22, 2022 Category: Respiratory Medicine Authors: Moslemi, A., Kontogianni, K., Brock, J., Wood, S., Herth, F., Kirby, M. Tags: COPD and smoking, Lung imaging, Asthma and allergy Original Articles: Airway diseases and imaging Source Type: research
Top Local Changemakers Addressing Health Equity Gaps Across the U.S. Named Johnson & Johnson Health Equity Innovation Challenge Awardees
NEW BRUNSWICK, N.J., June 14, 2022 – After an extensive search for the top changemakers in six key U.S. cities, Johnson & Johnson today announced the 14 awardees of its Health Equity Innovation Challenge. The awardees, who possess lived experience and a deep understanding of the communities they serve, were selected for their work in generating solutions to help close racial health and mortality gaps in six cities where Black and Brown individuals experience significant health inequities: Chicago, Detroit, Los Angeles, New Orleans, New York City and Philadelphia.The Health Equity Innovation Challenge was created by J...
Source: Johnson and Johnson - June 14, 2022 Category: Pharmaceuticals Tags: Innovation Source Type: news
New Analyses Suggest Favorable Results for STELARA ® (ustekinumab) When Used as a First-Line Therapy for Bio-Naïve Patients with Moderately to Severely Active Crohn’s Disease and Ulcerative Colitis
SPRING HOUSE, PENNSYLVANIA, October 25, 2021 – The Janssen Pharmaceutical Companies of Johnson & Johnson today announced data from two new analyses of STELARA® (ustekinumab) for the treatment of adults with moderately to severely active Crohn’s disease (CD) and ulcerative colitis (UC).1,2 In a modelled analysisa focused on treatment sequencing using data from randomized controlled trials, network meta-analysis and literature, results showed patient time spent in clinical remission or response was highest when STELARA was used as a first-line advanced therapy for bio-naïve patients with moderately to severely acti...
Source: Johnson and Johnson - October 25, 2021 Category: Pharmaceuticals Tags: Innovation Source Type: news
Artificial intelligence/machine learning in respiratory medicine and potential role in asthma and COPD diagnosis
Publication date: Available online 19 February 2021Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Alan Kaplan, Hui Cao, J. Mark FitzGerald, Nick Iannotti, Eric Yang, Janwillem W.H. Kocks, Konstantinos Kostikas, David Price, Helen K. Reddel, Ioanna Tsiligianni, Claus F. Vogelmeier, Pascal Pfister, Paul Mastoridis
Source: The Journal of Allergy and Clinical Immunology: In Practice - February 20, 2021 Category: Allergy & Immunology Source Type: research
Osteoporosis and Sarcopenia Increase Frailty Syndrome in the Elderly
Conclusions
World population is aging and the increase in life expectancy is often unhealthy. In particular, musculoskeletal aging, which leads to sarcopenia and osteoporosis, has several causes such as changes in body composition, inflammation, and hormonal imbalance. Sarcopenia, osteoporosis, and more frequently, sarcopenic obesity are commonly associated with aging and frequently closely linked each other, often leading to the development of a frailty syndrome. Frailty syndrome favors an increased risk of loss function in daily activities, for cardiovascular diseases, cancers, falls, and mortality. As the number of eld...
Source: Frontiers in Endocrinology - April 23, 2019 Category: Endocrinology Source Type: research
A Bidirectional Label Propagation Based Computational Model for Potential Microbe-Disease Association Prediction
Discussion
There are numerous microbial communities inhabited in the human body, which is critical to human health. The relationship between human microbiome and diseases received much attention from both medical and bioinformatics community recently. However, traditional methods to detect their association is costly and labor-intensive. Thus, we proposed here a new computational model called NBLPIHMDA to infer potential microbe-disease associations. NBLPIHMDA first combined known microbe-disease associations in HMDAD and the Gaussian interaction profile kernel similarity to construct disease similarity network and microb...
Source: Frontiers in Microbiology - April 8, 2019 Category: Microbiology Source Type: research
A Novel Human Microbe-Disease Association Prediction Method Based on the Bidirectional Weighted Network
Conclusion
Human microbiome is normal flora for humans, which has been proved to be of symbiotic relationship with humans and harmless to humans. If the microbes that breed in the human body become “unhealthy,” it will definitely affect the host's physical condition. People are continuing to explore the pathologic relationship between microorganisms and the human body through high-throughput sequencing technologies and analysis systems. However, it is a pity that their pathogenesis cannot be fully understood as yet. Considering that relying only on conventional experimental methods is time-consumin...
Source: Frontiers in Microbiology - April 8, 2019 Category: Microbiology Source Type: research
What are Indications for Continuous Positive Airway Pressure (CPAP)?
DiscussionObstructive sleep apnea syndrome (OSAS) is defined as a “disorder of breathing during sleep characterized by prolonged partial upper airway obstruction and/or intermittent complete obstruction (obstructive apnea) that disrupts normal ventilation during sleep and normal sleep patterns.” It is different than primary snoring which is snoring without apnea, sleep arousals, or problems with gas exchange.
OSAS symptoms include snoring (often with snorts, gasps or pauses), disturbed sleep (often frequent arousals) and daytime neurobehavioral problems. Sleepiness during the day can occur but is less common in...
Source: PediatricEducation.org - June 12, 2017 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news
Developing a Virtual Teach-To-Goal ™ Inhaler Technique Learning Module: A Mixed Methods Approach
Conclusions V-TTG™ is a promising educational tool for improving patients' inhaler technique, iteratively developed and refined with patient input. Patients in our urban, academic hospital overwhelmingly reported access to platforms and willingness to use V-TTG™ for health education.
Source: The Journal of Allergy and Clinical Immunology: In Practice - June 7, 2017 Category: Allergy & Immunology Source Type: research
How Common is α -1-Antitrypsin Deficiency?
Discussion
α-1-Antitrypsin Deficiency (A1AT) is a common single-gene mutation disease that is homozygous recessive. The normal allele is called M and the most common abnormal allele is Z. There are other alleles though. The gene codes for one of the primary protease inhibitors in the serum, thus those who are homozygous for the Z gene are sometimes referred to as “PIZZ” or “PIZ.” α-1-Antitrypsin is found in all body tissues but is especially important in the serum and lung. As noted it is one of the primary neutrophil protease inhibitors in the serum, and acts to neutralize these enzymes...
Source: PediatricEducation.org - April 24, 2017 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news
Symptom Profiles and Inflammatory Markers in COPD Symptom Profiles and Inflammatory Markers in COPD
Find out more about the symptom profiles in COPD -- and learn how they are associated with biomarkers of inflammation.BMC Pulmonary Medicine
Source: Medscape Allergy Headlines - February 13, 2017 Category: Allergy & Immunology Tags: Pulmonary Medicine Journal Article Source Type: news
Multiple Threats to Child Health from Fossil Fuel Combustion: Impacts of Air Pollution and Climate Change
Conclusion: Going beyond the powerful scientific and economic arguments for urgent action to reduce the burning of fossil fuels is the strong moral imperative to protect our most vulnerable populations.
Citation: Perera FP. 2017. Multiple threats to child health from fossil fuel combustion: impacts of air pollution and climate change. Environ Health Perspect 125:141–148; http://dx.doi.org/10.1289/EHP299
Address correspondence to F.P. Perera, Department of Environmental Health Sciences, Columbia Center for Children’s Environmental Health, Columbia University Mailman School of Public Health, 722 West 168th St. 12th flo...
Source: EHP Research - February 1, 2017 Category: Environmental Health Authors: Web Admin Tags: Commentaries Children's Health February 2017 Source Type: research
Virtual Teach-To-Goal ™ Adaptive Learning of Inhaler Technique for Inpatients with Asthma or COPD
Conclusions This study is the first to demonstrate the efficacy of adaptive V-TTG™ learning to teach the inhaler technique. V-TTG™ improved most participants' technique to an acceptable level, reached mastery for half, and also increased self-efficacy and actualized skill. V-TTG™ has potential to improve health care across care transitions.
Source: The Journal of Allergy and Clinical Immunology: In Practice - January 5, 2017 Category: Allergy & Immunology Source Type: research
What can we learn from blood granulocyte patterns in patients with asthma?
There has been an explosion in interest in the utility of the blood eosinophil count as a biomarker in patients with airway disease. It is a readily accessible measure, and studies have shown a consistent positive relationship between the blood eosinophil count and the risk of exacerbations [1–6], and the extent to which this can be reduced by inhaled corticosteroids (ICS) [3–5] and anti-interleukin-5 monoclonal antibodies [6–8]. Much of the work to date has been carried out in patients with severe asthma or has involved post hoc analysis of intervention studies of ICS in patients with moderate-to-severe ...
Source: European Respiratory Journal - September 29, 2016 Category: Respiratory Medicine Authors: Hambleton, K., Pavord, I. D. Tags: Asthma and allergy Editorials Source Type: research
