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Condition: Arthritis

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Total 2071 results found since Jan 2013.

Cow's milk allergy in infancy and later development of juvenile idiopathic arthritis: A register-based case-control study.
Abstract We have examined the association between cow's milk allergy (CMA) and juvenile idiopathic arthritis (JIA). The material for this case-control-study was collected from national registers of all children born between 2000 and 2010 in Finland and diagnosed with JIA (n = 1,298) and age-, gender- and place-matched controls (n = 5,179). We identified 235 children with CMA, 66 of these also had JIA. A conditional logistic regression analysis was performed to evaluate the association between CMA and JIA and to test whether exposure to antibiotics would be a covariate for this association. In boys, but not in ...
Source: Am J Epidemiol - April 28, 2017 Category: Epidemiology Authors: Arvonen M, Lauri J, Virta, Pokka T, Kröger L, Vähäsalo P Tags: Am J Epidemiol Source Type: research

Omega-3s Tied to Lower Risk of Rheumatoid ArthritisOmega-3s Tied to Lower Risk of Rheumatoid Arthritis
Women who have diets high in omega-3 fatty acids derived from fish are less likely to develop rheumatoid arthritis (RA) than those who skimp on fish, new research suggests. Reuters Health Information
Source: Medscape Allergy Headlines - August 24, 2013 Category: Allergy & Immunology Tags: Allergy & Clinical Immunology News Source Type: news

In human basophils, IL–3 selectively induces RANKL expression that is modulated by IgER–dependent and –independent stimuli
ConclusionThis study identifies IL‐3 as a potent inducer of RANKL expression in human basophils, suggesting them to interact with bone physiology and activation of immune cells. IgER‐dependent and ‐independent stimuli modulate the IL‐3‐mediated RANKL expression in a time and stimulus dependent fashion.This article is protected by copyright. All rights reserved.
Source: Allergy - July 29, 2014 Category: Allergy & Immunology Authors: Cristina Huber, Andrea Odermatt, Björn Hagmann, Clemens A. Dahinden, Michaela Fux Tags: Original Article: Experimental Allergy and Immunology Source Type: research

Effect of antioxidants and nutrients in patients with allergy and asthma
I read with much interest the article by Moreno-Macias and Romieu.1 The authors discussed the importance of antioxidant supplements and nutrients. Over the last decade, my colleagues and I have performed experimental laboratory studies on various potential herbs and their extracts. Many of the oxidative stress disorders in experimental animals were shown to have fewer complications or even the damages were reverted once treated with herbal supplements. Notable to mention is the effect of Piper betel and Momordica charantia on experimentally induced type 2 diabetes and of Curcuma longa on experimentally induced rheumatoid arthritis.
Source: Journal of Allergy and Clinical Immunology - July 25, 2014 Category: Allergy & Immunology Authors: Srijit Das Source Type: research

Reactive Oxygen Species in Psoriasis and Psoriasis Arthritis: Relevance to Human Disease
Psoriasis (Ps) is a chronic, immune-mediated, skin inflammatory disease affecting up to 3% of the population worldwide. Different environmental triggers initiate this complex multifactorial syndrome. Many individuals affected by Ps (6-26%) develop inflammatory disease in other organs, often in the joints as in psoriasis arthritis (PsA). Animal models that reflect the typical Ps syndrome, including both skin and joint pathology as in Ps and PsA, are valuable tools for dissecting disease pathways leading to clinical manifestations. In this context, we developed a new acute Ps and PsA-like disease model that appears after exp...
Source: International Archives of Allergy and Immunology - March 19, 2015 Category: Allergy & Immunology Source Type: research

Epicutaneous Immunization with Collagen Induces TCRαβ Suppressor T Cells That Inhibit Collagen-Induced Arthritis
Conclusions: The suppression of inflammatory responses by T suppressor cells induced through EC immunization of a protein antigen may become an attractive noninvasive therapeutic method for a variety of clinical situations.Int Arch Allergy Immunol 2015;166:121-134
Source: International Archives of Allergy and Immunology - March 19, 2015 Category: Allergy & Immunology Source Type: research

Allergies: Food Allergy Link to Forms of Arthritis
Arthritis is one of the most debilitating conditions in the United States of America. Arthritis is the number one cause of lost work days for employees of the Boeing Corporation, for example. Treatment is limited and almost entirely concentrated on anti-inflammatory medications, not on eliminating the original cause of the inflammation. The word, 'arthritis,' means, 'joint inflammation.' There are basically two forms of arthritis, osteoarthritis and rheumatoid arthritis.
Source: Disabled World - March 24, 2015 Category: Disability Tags: Food Allergy Source Type: news

The pathogenesis of rheumatoid arthritis is associated with milk or egg allergy
Conclusion: The results suggest that pathogenesis of RA correlates closely to increased egg- or milk-specific antibodies.
Source: North American Journal of Medical Sciences - January 29, 2016 Category: Journals (General) Authors: Jianjie LiHao YanHe ChenQiongmei JiShengguang HuangPingchang YangZhigang LiuBo Yang Source Type: research

The Role of TRAF4 and B3GAT1 Gene Expression in the Food Hypersensitivity and Insect Venom Allergy in Mastocytosis
Abstract Mastocytosis is an uncommon disease classified as a myeloproliferative neoplasm, however, its symptoms are broad and place patients at crossroads between dermatology, hematology and allergology. Patients with mastocytosis often suffer from symptoms resulting from the activation and release of mediators from the mast cells, such as generalized itching, redness, headache, abdominal cramps, diarrhea, bone pain or arthritis, hypotension and shock. The possible severe, fatal or near fatal reactions caused by food hypersensitivity are reasons for the research focused on marker identification. The aim of the stu...
Source: Archivum Immunologiae et Therapiae Experimentalis - April 15, 2016 Category: Allergy & Immunology Source Type: research

Diagnoses and Management of Drug Hypersensitivity and Anaphylaxis in Cancer and Chronic Inflammatory Diseases: Reactions to Taxanes and Monoclonal Antibodies.
Abstract Due to the increase in utilization of chemotherapies and antibodies, drug hypersensitivity reactions have increased dramatically worldwide, preventing the use of first-line therapies and impacting patients' survival and quality of life. Some of the more frequently used medications in cancer include taxanes for ovarian, lung, breast, and prostate cancers. Monoclonal antibodies are used in the treatment of neoplastic, autoimmune, and inflammatory diseases, and their clinical applications are becoming broader. Monoclonal antibody targets include CD20, HER-2, EGFR, IL-6 receptor, TNF-α, CD30, VEGF-A, IgE, an...
Source: Clinical Colorectal Cancer - June 7, 2016 Category: Cancer & Oncology Authors: Bonamichi-Santos R, Castells M Tags: Clin Rev Allergy Immunol Source Type: research

GPR91 deficiency exacerbates allergic contact dermatitis while reducing arthritic disease in mice
ConclusionsA deficiency in succinate sensing during mast cell development confers these cells with a hyperactive phenotype. Such a phenomenon does not translate into exacerbation of asthma or mast cell dependent arthritis. On the contrary, the fact that Sucnr1‐/‐ mice developed reduced arthritic disease, using two different in vivo models, indicates that GPR91 antagonists may have therapeutic potential for the treatment of allergic and autoimmune diseases.This article is protected by copyright. All rights reserved.
Source: Allergy - August 16, 2016 Category: Allergy & Immunology Authors: Tina Rubi ć‐Schneider, Nicole Carballido‐Perrig, Camille Regairaz, Layla Raad, Sandra Jost, Celine Rauld, Brigitte Christen, Grazyna Wieczorek, Robert Kreutzer, Janet Dawson, Günther Lametschwandner, Amanda Littlewood‐Evans, José M. Carballido Tags: Original Article: Experimental Allergy and Immunology Source Type: research

A systematic review of the role of interleukin-17 and the interleukin-20 family in inflammatory allergic skin diseases
Purpose of review: Allergic skin diseases include atopic dermatitis/eczema, contact dermatitis, and drug hypersensitivity. Allergic skin diseases have a high prevalence. Atopic dermatitis is one of the most common inflammatory skin diseases and similar for allergic rhinitis and allergic asthma. Over a long period, allergic diseases have been regarded as immunoglobulin E-mediated T-helper-2 (Th2)-driven. But new cytokines and T cells have been discovered within the last years. In this systematic review, the focus is laid on interleukin-17 (IL-17) and the interleukin-20 (IL-20) family which appear to be fine-tuning the Th2-d...
Source: Current Opinion in Allergy and Clinical Immunology - September 2, 2016 Category: Allergy & Immunology Tags: SKIN ALLERGY: Edited by Thomas Werfel and Torsten Zuberbier Source Type: research

Immunosuppressive Activity of Abatacept on Circulating T Helper Lymphocytes from Juvenile Idiopathic Arthritis Patients
Conclusions: Abatacept in vitro inhibits proliferation and cytokine production in healthy donors, and reduces parameters of inflammation in vivo in JIA patients. The reduction of the proliferative response to recall antigens induced by abatacept was evident only soon after drug administration, suggesting that its immunosuppressive activity is maintained only for a short time.Int Arch Allergy Immunol 2016;171:45-53
Source: International Archives of Allergy and Immunology - November 7, 2016 Category: Allergy & Immunology Source Type: research

Undetectable Mannose Binding Lectin and Corticosteroids Increase Serious Infection Risk in Rheumatoid Arthritis
Conclusions Undetectable MBL and prednisolone confer a high risk for an SI. The use of biologic DMARDs did not confer substantial SI risk in this observational study. MBL deficiency is hitherto an unrecognized risk factor for an SI in RA.
Source: The Journal of Allergy and Clinical Immunology: In Practice - June 20, 2017 Category: Allergy & Immunology Source Type: research

Cow's Milk Allergy in Infancy and Later Development of Juvenile Idiopathic Arthritis: A Register-Based Case-Control Study
We examined the association between cow's milk allergy (CMA) and juvenile idiopathic arthritis (JIA). The material for this case-control study was collected from national registers of all children born in Finland between 2000 and 2010 and diagnosed with JIA (n = 1,298) and age-, sex-, and place-matched controls (n = 5,179). We identified 235 children with CMA; 66 of these children also had JIA. A conditional logistic regression analysis was performed to evaluate the association between CMA and JIA and to test whether exposure to antibiotics would be a covariate for this association. In boys (but not in gir ls), a diagn...
Source: American Journal of Epidemiology - June 24, 2017 Category: Epidemiology Source Type: research