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Janssen to Present the Strength and Promise of its Hematologic Malignancies Portfolio and Pipeline at ASH 2021
RARITAN, N.J., November 4, 2021 – The Janssen Pharmaceutical Companies of Johnson & Johnson announced today that more than 45 company-sponsored abstracts, including 11 oral presentations, plus more than 35 investigator-initiated studies will be featured at the American Society of Hematology (ASH) Annual Meeting and Exposition. ASH is taking place at the Georgia World Congress Center in Atlanta and virtually from December 11-14, 2021.“We are committed to advancing the science and treatment of hematologic malignancies and look forward to presenting the latest research from our robust portfolio and pipeline during ASH...
Source: Johnson and Johnson - November 5, 2021 Category: Pharmaceuticals Tags: Innovation Source Type: news

A Comparative Study of TAVR versus SAVR in Moderate and High-Risk Surgical Patients: Hospital Outcome and Midterm Results.
CONCLUSION: In this study, we could not detect an advantage in survival when SAVR or TAVR were utilized in intermediate to high surgical risk patients needing aortic valve replacement for severe aortic stenosis. PMID: 31596707 [PubMed - in process]
Source: The Heart Surgery Forum - August 26, 2019 Category: Cardiovascular & Thoracic Surgery Authors: Abdelgawad AME, Hussein MA, Naeim H, Abuelatta R, Alghamdy S Tags: Heart Surg Forum Source Type: research

Preventable Cases of Oral Anticoagulant-Induced Bleeding: Data From the Spontaneous Reporting System
Conclusion: Our findings describe the most reported risk factors for preventability of oral anticoagulant-induced bleedings. These factors may be useful for targeting interventions to improve pharmacovigilance activities in our regional territory and to reduce the burden of medication errors and inappropriate prescription. Introduction Oral anticoagulant therapy is widely used for the prevention of stroke and systemic embolism in patients with atrial fibrillation, or for the prevention and treatment of deep vein thrombosis and pulmonary embolism (Raj et al., 1994; Monaco et al., 2017). Oral anticoagulants can be di...
Source: Frontiers in Pharmacology - April 29, 2019 Category: Drugs & Pharmacology Source Type: research

Transcatheter aortic valve implantation compared with surgical aortic valve replacement in patients with anaemia.
CONCLUSIONS: These results suggest that TAVI is not superior to SAVR in patients with anaemia. PMID: 28812435 [PubMed - as supplied by publisher]
Source: Acta Cardiologica - August 17, 2017 Category: Cardiology Tags: Acta Cardiol Source Type: research

Combined Erythropoietin and Iron Therapy for Anemic Patients Undergoing Transcatheter Aortic Valve Replacement: The EPICURE Randomized Clinical Trial.
CONCLUSIONS: EPO administration failed to reduce RC transfusion rate or the per-patient number of transfusion units in anemic patients undergoing TAVI. PMID: 28067195 [PubMed - as supplied by publisher]
Source: EuroIntervention - January 12, 2017 Category: Cardiovascular & Thoracic Surgery Tags: EuroIntervention Source Type: research

Pre-treatment clinical assessment in head and neck cancer: United Kingdom National Multidisciplinary Guidelines.
Authors: Robson A, Sturman J, Williamson P, Conboy P, Penney S, Wood H Abstract This is the official guideline endorsed by the specialty associations involved in the care of head and neck cancer patients in the UK. This paper provides recommendations on the pre-treatment clinical assessment of patients presenting with head and neck cancer. Recommendations • Comorbidity data should be collected as it is important in the analysis of survival, quality of life and functional outcomes after treatment as well as for comparing results of different treatment regimens and different centres. (R) • Patients with hypertens...
Source: Journal of Laryngology and Otology - November 15, 2016 Category: ENT & OMF Tags: J Laryngol Otol Source Type: research

Aortic valve surgery in octogenarians: Risk factors and long-term impact
Conclusions The morbidity and mortality of aortic valve surgery for patients over age 80 has decreased in recent years, although it remains higher when valve surgery is combined with coronary surgery. The presence of preoperative left ventricular dysfunction decreases long-term survival.
Source: Revista Clinica Espanola - November 6, 2014 Category: Internal Medicine Source Type: research

The Influence of Preoperative Anaemia on Postoperative Outcomes in First Time Elective Isolated Aortic Valve Replacement Surgery in the Prince Charles Hospital: A Ten-Year Review
This study aims to assess the relationship between preoperative anaemia and postoperative clinical outcomes in elective isolated aortic valve replacement (AVR) patients from The Prince Charles Hospital (TPCH).
Source: Heart, Lung and Circulation - January 1, 2014 Category: Cardiology Authors: Y. Ranawaka, C. Villanueva, B. Pearse, S. Gabriel, J. McGree, L. Nair, H. Thompson, D. Wall, P. Tesar Tags: Abstracts Source Type: research

Cardiac Critical Care After Transcatheter Aortic Valve Replacement
Transcatheter aortic valve replacement (TAVR) is a new therapy for severe aortic stenosis now available in the United States. Initial patients eligible for TAVR are defined by high operative risk, with advanced age and multiple comorbidities. Following TAVR, patients experience acute hemodynamic changes and several possible complications, including hypotension, vascular injury, anemia, stroke, new-onset atrial fibrillation, conduction disturbances and kidney injury, requiring an acute phase of intensive care. Alongside improvements in TAVR technology and technique, improvements in care after TAVR may contribute to improved...
Source: Cardiology Clinics - November 1, 2013 Category: Cardiology Authors: Matthew I. Tomey, Umesh K. Gidwani, Samin K. Sharma Source Type: research

Two‐ and Three‐Dimensional Transthoracic Echocardiography in the Assessment of Aortic Arch Vasum Vasi to Pulmonary Artery Fistula
We report an elderly patient presenting with a stroke and also hemolytic anemia secondary to mitral and tricuspid valve repair 3 years earlier, in whom two‐dimensional transesophageal echocardiography (2DTEE) suspected a fistula into the pulmonary artery (APAF) from the posterior wall of the aortic arch. For further assessment, two‐dimensional transthoracic echocardiography (2DTTE) and live/real time three‐dimensional transthoracic echocardiography (3DTTE) were performed. 2DTTE showed findings similar to 2DTEE. Color Doppler guided continuous‐wave Doppler showed continuous flow throughout the cardiac cycle with sy...
Source: Echocardiography - January 11, 2013 Category: Cardiology Authors: Kamel Sadat, Manish Pradhan, Navin C. Nanda, Deepak Joshi, Hari Prakash Diddi Tags: Research from the University of Alabama at Birmingham Source Type: research