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Specialty: Hematology
Condition: Anemia

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Total 197 results found since Jan 2013.

Safety and effectiveness of a Patient Blood Management Programme in surgical patients – the study design for a multicentre epidemiological non‐inferiority trial by the German PBM network
ConclusionsThis trial will determine whether the implementation of a PBM programme is safe and effective in terms of clinical outcome. Data will be compared to data prior to implementation of PBM in (the same?) 20 Germany hospitals.
Source: ISBT Science Series - April 13, 2015 Category: Hematology Authors: P. Meybohm, D. P. Fischer, E. Herrmann, C. Geisen, M. M. Müller, E. Seifried, A. U. Steinbicker, C. F. Weber, K. D. Zacharowski, Tags: Invited Review Source Type: research

How I treat and manage strokes in sickle cell disease
Neurologic complications are a major cause of morbidity and mortality in sickle cell disease (SCD). In children with sickle cell anemia, routine use of transcranial Doppler screening, coupled with regular blood transfusion therapy, has decreased the prevalence of overt stroke from ~11% to 1%. Limited evidence is available to guide acute and chronic management of individuals with SCD and strokes. Current management strategies are based primarily on single arm clinical trials and observational studies, coupled with principles of neurology and hematology. Initial management of a focal neurologic deficit includes evaluation by...
Source: Blood - May 28, 2015 Category: Hematology Authors: Kassim, A. A., Galadanci, N. A., Pruthi, S., DeBaun, M. R. Tags: Sickle Cell Disease, How I Treat, Free Research Articles, Red Cells, Iron, and Erythropoiesis, Clinical Trials and Observations Source Type: research

Liver iron concentration measurements by MRI in chronically transfused children with sickle cell anemia: Baseline results from the TWiTCH trial
This article is protected by copyright. All rights reserved.
Source: American Journal of Hematology - June 19, 2015 Category: Hematology Authors: John C. Wood, Sara Pressel, Zora R. Rogers, Isaac Odame, Janet L. Kwiatkowski, Margaret T. Lee, William C. Owen, Alan R. Cohen, Timothy St. Pierre, Matthew M. Heeney, William H. Schultz, Barry R. Davis, Russell E. Ware, Tags: Research Article Source Type: research

Association between ENPP1 K173Q and stroke in a newborn cohort of 395 Brazilian children with sickle cell anemia
Source: Blood - September 3, 2015 Category: Hematology Authors: Belisario, A. R., Sales, R. R., Toledo, N. E., Velloso-Rodrigues, C., Silva, C. M., Viana, M. B. Tags: Pediatric Hematology, Sickle Cell Disease, Red Cells, Iron, and Erythropoiesis CORRESPONDENCE Source Type: research

Baseline SYNTAX Score and Long-Term Outcome in Patients With ST-Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention
Conclusion: The SXscore is an independent predictor of both in-hospital and long-term mortality and MACE in patients with acute STEMI undergoing primary PCI.
Source: Clinical and Applied Thrombosis/Hemostasis - October 5, 2015 Category: Hematology Authors: Akgun, T., Oduncu, V., Bitigen, A., Karabay, C. Y., Erkol, A., Kocabay, G., Ozveren, O., Yildiz, A., Cimen, A. O., Kirma, C. Tags: Original Articles Source Type: research

Organ iron accumulation in chronically transfused children with sickle cell anaemia: baseline results from the TWiTCH trial
We report the baseline findings of abdominal organ iron burden in 121 participants. At enrollment, patients were young (9·8 ± 2·9 years), predominantly female (60:40), and previously treated with transfusions (4·1 ± 2·4 years) and iron chelation (3·1 ± 2·1 years). Liver iron concentration (LIC; 9·0 ± 6·6 mg/g dry weight) and serum ferritin were moderately elevated (2696 ± 1678 μg/l), but transferrin was incompletely saturated (47·2 ± 23·6%). Spleen R2* was 509 ± 399 Hz (splenic iron ~13·9 mg/g) and correlated with LIC (r2 = 0·14, P = 0·0008). Pancreas R2* was increased in 38·3...
Source: British Journal of Haematology - November 2, 2015 Category: Hematology Authors: John C. Wood, Alan R. Cohen, Sara L. Pressel, Banu Aygun, Hamayun Imran, Lori Luchtman‐Jones, Alexis A. Thompson, Beng Fuh, William H. Schultz, Barry R. Davis, Russell E. Ware, Tags: Research Paper Source Type: research

Complications of sickle cell anaemia in children in Northwestern Tanzania.
Conclusion Children with SCA receiving care in Tanzania are diagnosed late, hospitalized frequently, and have severe complications. Opportunities exist to improve care through wider access to screening and diagnosis as well as better coordination of comprehensive care. PMID: 26868490 [PubMed - as supplied by publisher]
Source: Hematology - February 14, 2016 Category: Hematology Tags: Hematology Source Type: research

Reduced rate of sickle‐related complications in Brazilian patients carrying HbF‐promoting alleles at the BCL11A and HMIP‐2 loci
Summary The presence of high levels of fetal haemoglobin (HbF) provides well‐validated clinical benefits to patients with sickle cell anaemia (SCA). Nevertheless it has been difficult to show clear direct effects of the known genetic HbF modifiers, such as the enhancer polymorphisms for haematopoietic transcription factors BCL11A and MYB, on SCA severity. Investigating SCA patients from Brazil, with a high degree of European genetic admixture, we have detected strong effects of these variants on HbF levels. Critically, we have shown, for the first time, that the presence of such HbF‐promoting variants leads to a reduce...
Source: British Journal of Haematology - February 1, 2016 Category: Hematology Authors: Flávia C. Leonardo, Ana F. Brugnerotto, Igor F. Domingos, Kleber Y. Fertrin, Dulcinéia M. Albuquerque, Marcos A. C. Bezerra, Aderson S. Araújo, Sara T. O. Saad, Fernando F. Costa, Stephan Menzel, Nicola Conran, Swee Lay Thein Tags: Short Report Source Type: research

Effectiveness of red blood cell exchange, partial manual exchange, and simple transfusion concurrently with iron chelation therapy in reducing iron overload in chronically transfused sickle cell anemia patients.
CONCLUSION: We recommend RCE plus chelation as an effective method for reducing iron overload, while maintaining HbS at 30% to 35%. PMID: 26997031 [PubMed - as supplied by publisher]
Source: Transfusion - March 19, 2016 Category: Hematology Authors: Fasano RM, Leong T, Kaushal M, Sagiv E, Luban NL, Meier ER Tags: Transfusion Source Type: research

mTOR Inhibition Improves Anaemia and Reduces Organ Damage in a Murine Model of Sickle Cell Disease
In conclusion, mTOR inhibition is protective against anaemia and organ damage in a murine model of SCD.
Source: British Journal of Haematology - March 30, 2016 Category: Hematology Authors: Jintao Wang, Jennifer Tran, Hui Wang, Chiao Guo, David Harro, Andrew D. Campbell, Daniel T. Eitzman Tags: Research Paper Source Type: research

Improvement of medical care in a cohort of newborns with sickle‐cell disease in North Paris: impact of national guidelines
Summary We conducted a retrospective study on newborns with sickle‐cell disease (SCD), born 1995–2009, followed in a multicentre hospital‐based network. We assessed patient outcomes, medical care and compliance with the national guidelines published in December 2005. Data from 1033 patients (742 SS/Sβ°‐thalassaemia) with 6776 patient‐years of follow‐up were analysed (mean age 7·1 ± 3·9 years). SCD‐related deaths (n = 13) occurred only in SS‐genotype patients at a median age of 23·1 months, mainly due to acute anaemia (n = 5, including 2 acute splenic sequestrations) and infection (n = 3). Tr...
Source: British Journal of Haematology - April 6, 2016 Category: Hematology Authors: Nathalie Couque, Delphine Girard, Rolande Ducrocq, Priscilla Boizeau, Zinedine Haouari, Florence Missud, Laurent Holvoet, Ghislaine Ithier, Marie Belloy, Marie‐Héléne Odièvre, Michel Benemou, Patricia Benhaim, Brigitte Retali, Philippe Bensaid, Brigi Tags: Research Paper Source Type: research

Determinants of resting cerebral blood flow in sickle cell disease
In conclusion, sickle cell disease patients had sufficient oxygen delivery at rest, but accomplish this only by marked increases in their resting CBF, potentially limiting their ability to further augment flow in response to stress. This article is protected by copyright. All rights reserved.
Source: American Journal of Hematology - June 5, 2016 Category: Hematology Authors: Adam M. Bush, Matthew T. Borzage, Soyoung Choi, Lena Václavů, Benita Tamrazi, Aart J. Nederveen, Thomas D. Coates, John C Wood Tags: Research Article Source Type: research

Imaging Manifestations of Neurologic Complications in Anemia
Publication date: Available online 7 June 2016 Source:Hematology/Oncology Clinics of North America Author(s): Ritesh Patel, Shyam Sabat, Sangam KanekarTeaser The hallmark signs and symptoms of anemia are directly related to a decrease in oxygen delivery to vital tissues and organs and include pallor, fatigue, lightheadedness, and shortness of breath. Neurologic complications are often nonspecific and can include poor concentration, irritability, faintness, tinnitus, and headache. If undiagnosed or untreated, anemia can progress to cognitive dysfunction, psychosis, encephalopathy, myelopathy, peripheral neuropathy, and...
Source: Hematology Oncology Clinics of North America - June 6, 2016 Category: Hematology Source Type: research

Flanagan JM, Sheehan V, Linder H, et al. Genetic mapping and exome sequencing identify 2 mutations associated with stroke protection in pediatric patients with sickle cell anemia. Blood. 2013;121(16):3237-3245.
Source: Blood - June 15, 2016 Category: Hematology Tags: Free Research Articles ERRATA Source Type: research

A comparison of red blood cell transfusion utilization between anti ‐factor Xa and activated partial thromboplastin monitoring in patients receiving unfractionated heparin
ConclusionAnti‐Xa was associated with a significant reduction in RBC transfusions when compared to patients monitored by aPTT alone.This article is protected by copyright. All rights reserved.
Source: Journal of Thrombosis and Haemostasis - June 30, 2016 Category: Hematology Authors: K.W. Belk, M. Laposata, C. Craver Tags: Original Article ‐ Clinical Haemostasis and Thrombosis Source Type: research