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Condition: Cardiomyopathy

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Total 1426 results found since Jan 2013.

Early clinical and echocardiographic outcomes after SAPIEN 3 transcatheter aortic valve replacement in inoperable, high-risk and intermediate-risk patients with aortic stenosis
Conclusions The SAPIEN 3 THV system was associated with low rates of 30-day mortality and major/disabling stroke as well as low rates of moderate or severe paravalvular regurgitation. Trial Registration ClinicalTrials.gov #NCT01314313.
Source: European Heart Journal - July 20, 2016 Category: Cardiology Authors: Kodali, S., Thourani, V. H., White, J., Malaisrie, S. C., Lim, S., Greason, K. L., Williams, M., Guerrero, M., Eisenhauer, A. C., Kapadia, S., Kereiakes, D. J., Herrmann, H. C., Babaliaros, V., Szeto, W. Y., Hahn, R. T., Pibarot, P., Weissman, N. J., Leip Tags: TAVI Source Type: research

Association of CHADS2 and CHA2DS2-VASc Scores with Left Atrial Thrombus with Nonvalvular Atrial Fibrillation: A Single Center Based Retrospective Study in a Cohort of 2695 Chinese Subjects.
Abstract The main mechanism of the CHADS2 and CHA2DS2-VASc scores to predict stroke in nonvalvular atrial fibrillation (NVAF) is still controversial. We evaluated the association of the CHADS2 and CHA2DS2-VASc scores with left atrial thrombus (LAT) as detected by transesophageal echocardiographic (TEE) and compared the predictive ability of these risk stratification schemes with nonvalvular atrial fibrillation (NVAF). Data from 2,695 consecutive NVAF patients in whom TEE was performed for screening LAT from July 2007 to February 2014 were analyzed. Only 3% of the subjects had LAT. Presence of LAT was not significa...
Source: Biomed Res - April 5, 2017 Category: Research Authors: Huang J, Wu SL, Xue YM, Fei HW, Lin QW, Ren SQ, Liao HT, Zhan XZ, Fang XH, Xu L Tags: Biomed Res Int Source Type: research

Myocardial Energetics in AL and ATTR Cardiac Amyloidosis: A C-11 Acetate PET/CT Study
Conclusions: These results suggest that myocardial structure and energy utilization patterns differ between patients with AL-CMP and ATTR-CMP. Patients with AL-CMP have much lower myocardial mass and lower energy efficiency compared to patients with ATTR-CMP, suggesting better myocardial metabolic adaptation in ATTR-CMP. These findings if confirmed in a larger cohort suggest a role for novel therapeutics to manipulate substrate utilization in AL-CMP. AL-CMP(N=20)ATTR-CMP(N=3)P-ValueAge63 ± 6.380 ± 0.8<0.0001Rate Pressure Product, systolic blood pressure X heart rate, (mm Hg bpm)9228 ± 13608318 &plus...
Source: Journal of Nuclear Medicine - May 23, 2018 Category: Nuclear Medicine Authors: El-Sady, M. S., Kijewski, M., Jacob, S., Bravo, P., Dubey, S., Nodoushani, A., Belanger, A., Park, M.-A., Falk, R., Di Carli, M., Dorbala, S. Tags: Cardiac Metabolism, Viability, and Innervation Source Type: research

Neurogenic stress cardiomyopathy: What do we need to know.
Abstract The interaction between the heart and brain is complex and integral to the maintenance of normal cardiovascular function. Even in the absence of coronary disease, acute neuronal injury can induce a variety of cardiac changes. Recent neuroimaging data revealed a network including the insular cortex, anterior cingulate gyrus, and amygdala playing a crucial role in the regulation of central autonomic nervous system. Damage in these areas has been associated with arrhythmia, myocardial injury, higher plasma levels of brain natriuretic peptide, catecholamines, and glucose. Some patients after brain injury may ...
Source: Annals of Cardiac Anaesthesia - July 1, 2018 Category: Anesthesiology Authors: Gopinath R, Ayya SS Tags: Ann Card Anaesth Source Type: research

Septal Alcohol Ablation Versus Myectomy for Symptomatic Hypertrophic Obstructive Cardiomyopathy: Systematic Review and Meta ‐analysis
ConclusionCompared with SM, ASA is associated with lower peri ‐procedural mortality and stroke but higher rates of pacemaker implantations and re‐intervention. However, there was no difference between ASA and SM with regards to long‐term all‐cause mortality, cardiovascular mortality or SCD.This article is protected by copyright. All rights reserved.
Source: Clinical Cardiology - November 12, 2018 Category: Cardiology Authors: Mohammed Osman, Babikir Kheiri, Khansa Osman, Mahmoud Barbarawi, Hani Alhamoud, Fahad Alqahtani, Mohamad Alkhouli Tags: REVIEW Source Type: research

Age-Dependence of Flow Homeostasis in the Left Ventricle
Conclusions: In average, blood spends 1 to 3 beats inside the LV with very low shear stress rates. The apical region is the most prone to blood stasis, particularly in mid-aged adults. The washout of blood in the normal LV is age-dependent due to physiological changes in the degree of apical penetration of the filling waves. Introduction Cardioembolic stroke is a major source of mortality and disability worldwide and blood stasis one of its major determinants (Adams et al., 1986). Left ventricular (LV) function has evolved to maximize mechanical efficiency and ensure organ perfusion at a low cost of energy and fill...
Source: Frontiers in Physiology - April 25, 2019 Category: Physiology Source Type: research

Multiple Strokes in a Latin American Patient
We present a case of a recent immigrant from El Salvador without past medical history who presented to our hospital with symptoms concerning for acute stroke. Brain magnetic resonance imaging (MRI) with gadolinium confirmed an acute stroke along with multiple prior infarcts involving different vascular beds. Head magnetic resonance arteriogram did not reveal any occlusions/stenosis or aneurysmal changes. His subsequent extensive evaluation included an electrocardiogram (ECG) that revealed bifascicular block and echocardiography that suggested an apical aneurysm, but images were limited to assess. To further assess the like...
Source: Case Reports in Neurology - July 8, 2021 Category: Neurology Source Type: research

Tissue Inhibitor of Metalloproteinase-1 Is Increased in Chagasic Cardiomyopathy
Am J Trop Med Hyg. 2021 Jul 19:tpmd200401. doi: 10.4269/ajtmh.20-0401. Online ahead of print.ABSTRACTChagas disease (CD) mainly conveys stroke risk through structural cardiac disease. However, stroke and cognitive impairment are seen in CD independently of cardiac disease severity. Chronic inflammation may be an explanation for this association, because inflammation plays an important role in the pathogenesis of acute ischemic stroke and dementia. In the present study, we selected five candidate biomarkers for Chagas disease: interleukin-6, membrane metalloproteinase-9, tissue inhibitor of metalloproteinase-1 (TIMP1), oros...
Source: The American Journal of Tropical Medicine and Hygiene - July 19, 2021 Category: Tropical Medicine Authors: Karina Oliveira Garcia Thiago Cerqueira Silva Maria do Carmo Pereira Nunes Iuri Ferreira Felix Murilo Araujo Oliveira Maria Eduarda Lisboa Marques Leila Souza Brito Santos Paulo Roberto Sampaio Peixoto Sousa Pedro Jos é Ramiro Muiños Renata Martins Maia Source Type: research