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Specialty: Cancer & Oncology
Cancer: Thyroid Cancer

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Total 71 results found since Jan 2013.

siRNA targeting RBP2 inhibits expression, proliferation, tumorigenicity and invasion in thyroid carcinoma cells.
In conclusion, the transfection of RBP2-siRNA into papillary thyroid carcinoma K1 cells suppressed the expression of RBP2 in these cells, and reduced their proliferation, invasion, migration and tumorigenic potential. Therefore, targeting RBP2 may be an efficient approach to control thyroid carcinoma. PMID: 26788140 [PubMed - as supplied by publisher]
Source: Oncology Letters - January 21, 2016 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Small interfering RNA (siRNA) against Slug induces apoptosis and sensitizes human anaplastic thyroid carcinoma cells to doxorubicin.
CONCLUSIONS: Knockdown of Slug enhanced the antitumor activity of DOX in SW1736 cells via induction of PUMA upregulation. Our results suggest that targeting of Slug has good potential for the development of new therapeutic strategies for ATC. PMID: 28128736 [PubMed - as supplied by publisher]
Source: Cancer Biomarkers : Section A of Disease Markers - January 19, 2017 Category: Cancer & Oncology Authors: Pan Y, Liu P, Chen D, Zhao S Tags: Cancer Biomark Source Type: research

Exosome-mediated delivery of SCD-1 siRNA promoted the death of anaplastic thyroid carcinoma cells via regulating ROS level
ConclusionsExosomes loaded SCD-1 siRNA inhibited ATC cellular proliferation and promoted cellular apoptosis, and the mechanisms involved maybe the regulation of fatty acids metabolism and ROS level. Our study provides a promising therapeutic strategy for ATC.
Source: Clinical and Translational Oncology - January 29, 2022 Category: Cancer & Oncology Source Type: research

Identification of thyroid tumor cell vulnerabilities through a siRNA-based functional screening.
Authors: Anania M, Gasparri F, Cetti E, Fraietta I, Todoerti K, Miranda C, Mazzoni M, Re C, Colombo R, Ukmar G, Camisasca S, Pagliardini S, Pierotti M, Neri A, Galvani A, Greco A Abstract The incidence of thyroid carcinoma is rapidly increasing. Although generally associated with good prognosis, a fraction of thyroid tumors are not cured by standard therapy and progress to aggressive forms for which no effective treatments are currently available. In order to identify novel therapeutic targets for thyroid carcinoma, we focused on the discovery of genes essential for sustaining the oncogenic phenotype of thyroid tum...
Source: Oncotarget - October 3, 2015 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Sanguinarine Induces Apoptosis Pathway in Multiple Myeloma Cell Lines via Inhibition of the JaK2/STAT3 Signaling
In this study, we aimed to investigate the potential anti-proliferative and pro-apoptotic activities of SNG in a panel of MM cell lines (U266, IM9, MM1S, and RPMI-8226). SNG treatment of MM cells resulted in a dose-dependent decrease in cell viability through mitochondrial membrane potential loss and activation of caspase 3, 9, and cleavage of PARP. Pre-treatment of MM cells with a universal caspase inhibitor, Z-VAD-FMK, prevented SNG mediated loss of cell viability, apoptosis, and caspase activation, confirming that SNG-mediated apoptosis is caspase-dependent. The SNG-mediated apoptosis appears to be resulted from suppres...
Source: Frontiers in Oncology - April 16, 2019 Category: Cancer & Oncology Source Type: research

Long non-coding RNA ANRIL promotes the invasion and metastasis of thyroid cancer cells through TGF- β/Smad signaling pathway.
CONCLUSIONS: ANRIL may reduce p15INK4B expression through inhibiting TGF-β/Smad signaling pathway, promoting invasion and metastasis of TC cells, and the silencing of ANRIL inhibits the invasion and metastasis of TPC-1 cells. PMID: 27507052 [PubMed - as supplied by publisher]
Source: Oncotarget - August 13, 2016 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Knockdown of S100A4 blocks growth and metastasis of anaplastic thyroid cancer cells in vitro and in vivo.
Abstract Anaplastic thyroid cancer (ATC) is a locally aggressive type of thyroid tumor with high rate of distant metastases. It is often incurable because it does not respond to radioiodine, radiotherapy, or chemotherapy. With conventional treatment, the median survival is about 6 months; therefore, new treatment options are needed. S100A4 is a calcium-binding protein related to the metastatic potential of carcinoma. Previous study has found S100A4 was overexpressed in human papillary thyroid carcinomas (PTC) tissues, and overexpression of S100A4 is associated with thyroid tumour invasion and metastasis. In the pr...
Source: Cancer Biomarkers : Section A of Disease Markers - September 25, 2016 Category: Cancer & Oncology Authors: Zhang K, Yu M, Hao F, Dong A, Chen D Tags: Cancer Biomark Source Type: research

V600EBRAF promotes invasiveness of thyroid cancer cells by decreasing E-cadherin expression through a Snail-dependent mechanism
Highlights: ► BRAF depletion by siRNA decreases migration and invasion in thyroid cancer cells expressing oncogenic V600EBRAF. ► V600EBRAF inhibition by treatment with the PLX4720 inhibitor decreases migration and invasion in thyroid cancer cells. ► V600EBRAF induces cell invasion by a MEK/ERK-independent mechanism in thyroid cancer cells. ► V600EBRAF increases Snail expression with a concomitant decrease of its target E-cadherin.Abstract: BRAF is a main oncogene in human thyroid cancer. Here, we show that BRAF depletion by siRNA or inhibition of its activity by treatment with BRAF inhibitor PLX4720 decreases migra...
Source: Cancer Letters - March 14, 2013 Category: Cancer & Oncology Authors: Pablo Baquero, Irene Sánchez-Hernández, Eva Jiménez-Mora, Jose L. Orgaz, Benilde Jiménez, Antonio Chiloeches Tags: Research Articles Source Type: research

The cross‐talk between estrogen receptor and peroxisome proliferator‐activated receptor gamma in thyroid cancer
CONCLUSIONSThis study provides evidence supporting a cross‐talk between ER and PPARγ. The reciprocal interaction between PPARγ and ERβ significantly inhibits the proliferation and migration of thyroid cancer cells, providing a new therapeutic strategy against thyroid cancer. Cancer 2013. © 2013 American Cancer Society.
Source: Cancer - October 2, 2013 Category: Cancer & Oncology Authors: Ryan Chu, Andrew Hasselt, Alexander C. Vlantis, Enders K. W. Ng, Shirley Y. W. Liu, Michael Dahua Fan, Siu Kwan Ng, Amy B. W. Chan, Zhimin Liu, Xin‐ying Li, George G. Chen Tags: Original Article Source Type: research

miR-584 Suppresses Invasion and Cell Migration of Thyroid Carcinoma by Regulating the Target Oncogene ROCK1
Conclusion: These results indicate that miR-584 could inhibit the expression of ROCK1, and ROCK1 knockdown would further affect the migration ability of K1 cells.Oncol Res Treat 2015;38:436-440
Source: Oncology Research and Treatment - September 7, 2015 Category: Cancer & Oncology Source Type: research

Ribonucleotide reductase large subunit M1 plays a different role in the invasion and metastasis of papillary thyroid carcinoma and undifferentiated thyroid carcinoma
Abstract Ribonucleotide reductase (RR) has been reported to be associated with several types of cancer while the expression and role of RR in thyroid carcinoma (TC) has not been investigated. Here, we first examined the expression level of three RR subunit proteins (RRM1, RRM2, and RRM2B) in papillary thyroid carcinoma (PTC) and undifferentiated thyroid carcinoma (UTC) patient samples by immunohistochemistry. The results showed that RRM1 was higher expressed in 95.2 % cancer tissues compared with their adjacent normal tissues in 146 PTC samples. The expression level of RRM1 was positively correlated with T stage,...
Source: Tumor Biology - October 9, 2015 Category: Cancer & Oncology Source Type: research

Expression of BANCR promotes papillary thyroid cancer by targeting thyroid stimulating hormone receptor.
Authors: Zheng H, Xu J, Hao S, Liu X, Ning J, Song X, Jiang L, Liu Z Abstract Papillary thyroid carcinoma (PTC) is the most common form of non-medullary thyroid cancer, accounting for ~80% of all cases of thyroid cancer. The aim of the present study was to explore the role of BRAF-activated long noncoding RNA (BANCR) in the development of PTC. Using reverse transcription-quantitative polymerase chain reaction (RT-qPCR), the mRNA expression levels of BANCR, thyroid-stimulating hormone receptor (TSHR) and cyclin D1 between PTC and benign control thyroid nodule tissue samples from 60 patients were determined. Using RT...
Source: Oncology Letters - July 24, 2018 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

A-Kinase Interacting Protein 1 Knockdown Restores Chemosensitivity via Inactivating PI3K/AKT and β-Catenin Pathways in Anaplastic Thyroid Carcinoma
ConclusionAKIP1 knockdown decreases cell survival and invasion while promoting sensitivity to doxorubicin via inactivating PI3K/AKT and β-catenin pathways in ATC.
Source: Frontiers in Oncology - July 28, 2022 Category: Cancer & Oncology Source Type: research

Targeting SHP2 reverses BRAF inhibitor tolerance in anaplastic thyroid carcinoma
CONCLUSION: The SHP2 inhibitor SHP099 can effectively reverse the drug resistance of dabrafenib through inhibiting the reactivated RAS signaling pathway in anaplastic thyroid cancer.The combination of dabrafenib with SHP2 inhibitor has shown significant tumor suppressive effects for dabrafenib-resistant cells and it may be a new therapeutic strategy with longer lasting therapeutic benefits.PMID:36786145 | DOI:10.2174/1871520623666230214093122
Source: Cancer Control - February 14, 2023 Category: Cancer & Oncology Authors: Tao Tang Jie Zhou Li-Xin Zhang Gang Yang Wei-Nan Li Jian-Jiao Zhu Yong-Fu Xiong Jing-Dong Li Source Type: research