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Cause-specific mortality by education in Canada: a 16-year follow-up study.
This study examines cause-specific mortality rates by education in a broadly representative sample of Canadians aged 25 or older. The data are from the 1991 to 2006 Canadian census mortality follow-up study, which included about 2.7 million people and 426,979 deaths. Age-standardized mortality rates (ASMRs) were calculated by education for different causes of death. Rate ratios, rate differences and excess mortality were also calculated.
RESULTS: All-cause ASMRs were highest among people with less than secondary graduation and lowest for university degree-holders. If all cohort members had the mortality rates of those ...
Source: Health Reports - November 14, 2014 Category: Global & Universal Tags: Health Rep Source Type: research
Education, income and risk of cancer: results from a Norwegian registry-based study.
CONCLUSION: Our findings were consistent with findings from other studies showing that the incidence rate of cancer differs across levels of socioeconomic status. We may need behavioral change campaigns focused on lifestyle changes that lower the risk of cancer and target perhaps to those with lower socioeconomic status.
PMID: 32924698 [PubMed - as supplied by publisher]
Source: Acta Oncologica - September 13, 2020 Category: Cancer & Oncology Authors: Larsen IK, Myklebust TÅ, Babigumira R, Vinberg E, Møller B, Ursin G Tags: Acta Oncol Source Type: research
Do Cancer Patients Tweet? Examining the Twitter Use of Cancer Patients in Japan
Conclusions: This study demonstrates that cancer patients share information about their underlying disease, including diagnosis, symptoms, and treatments, via Twitter. This information could prove useful to health care providers.
Source: Journal of Medical Internet Research - May 27, 2014 Category: Journals (General) Authors: Atsushi TsuyaYuya SugawaraAtsushi TanakaHiroto Narimatsu Source Type: research
Adult children's socioeconomic positions and their parents' mortality: A comparison of education, occupational class, and income
Publication date: December 2014 Source:Social Science & Medicine, Volume 122 Author(s): Jenny Torssander Recent research has shown that the parents of well-educated children live longer than do other parents and that this association is only partly confounded by the parent's own socioeconomic position. However, the relationships between other aspects of children's socioeconomic position (e.g., occupational class and economic resources) and parental mortality have not been examined. Using the Swedish Multi-generation Register that connects parents to their children, this paper studies the associations of children'...
Source: Social Science and Medicine - November 11, 2014 Category: Psychiatry & Psychology Source Type: research
Role of respondents' education as a mediator and moderator in the association between childhood socio-economic status and later health and wellbeing
Conclusions:
Childhood financial conditions have a unique direct effect on a wide range of health and wellbeing measures. These findings apply to both men and women. Generally, parental education has an indirect effect on later health, but mothers' education may also have a long-term direct effect on later health.
Source: BioMed Central - November 18, 2014 Category: Journals (General) Authors: Mashhood Ahmed SheikhBirgit AbelsenJan Abel Olsen Source Type: research
Human blood plasma proteome mapping for search of potential markers of the lung squamous cell carcinoma.
Authors: Shevchenko VE, Kovalev SV, Arnotskaya NE, Zborovskaya IB, Akhmedov BB, Polotskii BE, Kostin AU, Moukeria AF, Zaridze DG, Davidov MI
Abstract
Blood plasma proteomes obtained from 77 lung squamous cell carcinoma (LSCC) patients (Stages I-III) and 67 healthy controls (all males) were analyzed by using the label-free liquid chromatography tandem mass spectrometry (LC-MS/MS) method for the search of potential cancer biomarkers. All plasma samples were depleted of 14 highly-abundant plasma proteins by immune-affinity column chromatography before LC-MS/MS. We identified and quantified 809 differential proteins wi...
Source: European Journal of Mass Spectrometry - December 1, 2014 Category: Chemistry Tags: Eur J Mass Spectrom (Chichester, Eng) Source Type: research
EGFR-TKIs combined with chemotherapy versus EGFR-TKIs single agent as first-line treatment for molecularly selected patients with non-small cell lung cancer
Abstract
EGFR-TKIs added to chemotherapy and EGFR-TKIs single agent have been used as first-line treatment for advanced non-small cell lung cancer patients with and without EGFR mutations. However, direct head-to-head comparison between them is still lacking. We performed indirect comparisons to assess the treatment effects of EGFR-TKIs added to chemotherapy versus EGFR-TKIs alone via common comparator of standard chemotherapy in both subgroups. A comprehensive literature search was undertaken. Finally, 12 randomized controlled trials enrolling more than 2,160 patients with EGFR mutation analysis met the inclusio...
Source: Medical Oncology - December 10, 2014 Category: Cancer & Oncology Source Type: research
A systematic review and meta-analysis of the association between OGG1 Ser326Cys polymorphism and cancers
This study aims to examine the association between the OGG1 Ser326Cys polymorphism and cancer risk based on meta-analysis. Relevant studies were identified through a search of PubMed and Weipu databases, and a total of 109 studies including 111 comparisons containing 34,041 cases and 42,730 controls were enrolled. Overall, significant association was observed between OGG1 Ser326Cys polymorphism and cancer risk in all genetic models except for heterozygote model (Cys/Cys + Cys/Ser vs Ser/Ser: OR 1.071, 95 % CI 1.019–1.125; Cys/Cys vs Cys/Ser + Ser/Ser: OR 1.159, 95 % CI 1.076–1.248; Cys/Cys vs Ser/Ser: OR 1.202, 9...
Source: Medical Oncology - January 15, 2015 Category: Cancer & Oncology Source Type: research
Treatment on advanced NSCLC: Platinum-based chemotherapy plus erlotinib or platinum-based chemotherapy alone? A systematic review and meta-analysis of randomised controlled trials
Abstract
We performed a systematic review and meta-analysis to assess the potential of erlotinib plus platinum-based chemotherapy relative to platinum-based chemotherapy alone for advanced non-small-cell lung cancer (NSCLC). Search of PubMed, EMBASE, Web of Science, CBM, CNKI, China Wan Fang databases and the Cochrane library was performed for studies regarding erlotinib plus platinum-based chemotherapy for advanced NSCLC published between 1 January 2000 and 28 August 2014. We identified eight eligible studies including 3,363 patients with advanced NSCLC. For PFS measure, an HR of 0.73 (0.58–0.93) with statisti...
Source: Medical Oncology - January 13, 2015 Category: Cancer & Oncology Source Type: research
Association of RAGE polymorphisms and cancer risk: a meta-analysis of 27 studies
Abstract
The receptor for advanced glycation end products (RAGE), a member of immunoglobulin superfamily, has been proved to stimulate survival, growth, and metastatic spread of cancers cells. Evidence suggested that the 82G/S, −374T/A, and −429T/C polymorphisms in RAGE promoter region might affect the risk of cancer; however, data from epidemiological studies showed conflicting results that remain to be further clarified. This meta-analysis was performed to derive a more precise estimation of 82G/S, −374T/A, and −429T/C polymorphisms and risk of cancer. A comprehensive electronic search was conducted for...
Source: Medical Oncology - January 21, 2015 Category: Cancer & Oncology Source Type: research
Overcoming resistance to targeted therapies in NSCLC: current approaches and clinical application
The discovery that a number of aberrant tumorigenic processes and signal transduction pathways are mediated by druggable protein kinases has led to a revolutionary change in nonsmall cell lung cancer (NSCLC) treatment. Epidermal growth factor receptor (EGFR) and anaplastic lymphoma kinase (ALK) are the targets of several tyrosine kinase inhibitors (TKIs), some of them approved for treatment and others currently in clinical development. First-generation agents offer, in target populations, a substantial improvement of outcomes compared with standard chemotherapy in the treatment of advanced NSCLC. Unfortunately, drug resist...
Source: Therapeutic Advances in Medical Oncology - August 20, 2015 Category: Cancer & Oncology Authors: Maione, P., Sacco, P. C., Sgambato, A., Casaluce, F., Rossi, A., Gridelli, C. Tags: Reviews Source Type: research
Thyroid metastasis from small cell lung carcinoma: a case report and review of the literature
Conclusions
We conclude that in a patient with a known history of malignant disease, the finding of a new thyroid mass should be promptly evaluated with a thyroid fine-needle aspiration biopsy to search for metastatic disease. The clinical features of our and two previously reported cases were summarized.
Source: Journal of Medical Case Reports - October 7, 2015 Category: Journals (General) Source Type: research
Predictive value of the official cancer alarm symptoms in general practice--a systematic review.
CONCLUSION: A few of the alarm symptoms show a high PPV, whereas the PPV for some symptoms currently remains unknown. To improve the GPs' diagnostic judgment, a new algorithm for calculating the PPV for combinations of symptoms and risk factors seems promising.
PMID: 26050833 [PubMed - in process]
Source: Danish Medical Journal - December 12, 2015 Category: Journals (General) Tags: Dan Med J Source Type: research
Texture analysis in CT and PET: A phantom study for features variability assessment
Purpose: In the field of Radiomics, the search for reliable and stable metrics is a central theme. The aim of this paper is to analyze textural features variability on phantom varying CT and PET clinical acquisitions parameters for the study of the Non Small Cells Lung Cancer and Head and Neck Cancer patients.
Source: Physica Medica: European Journal of Medical Physics - February 1, 2016 Category: Journals (General) Authors: G. Feliciani, M. Bertolini, F. Fioroni, M. Iori Source Type: research
Quantifying the mediating effects of smoking and occupational exposures in the relation between education and lung cancer: the ICARE study
Abstract
Smoking only partly explains the higher lung cancer incidence observed among socially deprived people. Occupational exposures may account for part of these inequalities, but this issue has been little investigated. We investigated the extent to which smoking and occupational exposures to asbestos, silica and diesel motor exhaust mediated the association between education and lung cancer incidence in men. We analyzed data from a large French population-based case–control study (1976 lung cancers, 2648 controls). Detailed information on lifelong tobacco consumption and occupational exposures to various ca...
Source: European Journal of Epidemiology - July 13, 2016 Category: Epidemiology Source Type: research
