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Cancer: Lung Cancer

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Total 1667 results found since Jan 2013.

Co ‑expression of murine double minute 2 siRNA and wild‑type p53 induces G1 cell cycle arrest in H1299 cells.
Co‑expression of murine double minute 2 siRNA and wild‑type p53 induces G1 cell cycle arrest in H1299 cells. Mol Med Rep. 2017 Oct 11;: Authors: Liu L, Zhang P, Guo H, Tang X, Liu L, Li J, Guo R, Cai Y, Liu Y, Li Y Abstract The therapeutic options available for the treatment of advanced non-small cell lung cancer have increased over the past decade. Small molecule gene therapy has emerged as an effective therapy for the treatment of lung cancer in vitro and in vivo although it has not been tested in a clinical setting. In particular, therapies that target the negative feedback loop between p53 an...
Source: Molecular Medicine Reports - October 20, 2017 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Antitumor activity of kinetochore-associated protein 2 siRNA against lung cancer patient-derived tumor xenografts.
Authors: Makita Y, Teratani M, Murata S, Hoashi Y, Matsumoto S, Kawamata Y Abstract It has been widely reported that patient-derived tumor xenografts (PDXs) are more similar to tumor tissues than conventional cancer cell lines. Kinetochore-associated protein 2 (KNTC2) is known to be upregulated specifically in tumor tissues of cancer patients and is recognized as a potential target for cancer therapy. Previously, in vivo antitumor activities of KNTC2 short interfering RNA encapsulated into a lipid nanoparticle (KNTC2-LNP) were reported in orthotopic hepatocellular carcinoma mouse models. However, it remains unclear...
Source: Oncology Letters - March 16, 2018 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Tip60-siRNA regulates ABCE1 acetylation to suppress lung cancer growth via activation of the apoptotic signaling pathway.
Authors: Liang Z, Yu Q, Ji H, Tian D Abstract Lung cancer is a leading cause of cancer-associated mortality and morbidity worldwide. Previous studies have suggested that ATP-binding cassette transporter E1 (ABCE1) acetylation is upregulated in the tissues and cells of lung cancer and is associated with the prognosis of patients with lung cancer. The aim of the present study was to investigate the association between Tat interactive protein 60 kDa (Tip60) expression and ABCE1 acetylation, and the effect of Tip60 on the biological functions of A549 lung carcinoma cells. The expression levels of Tip60 and ABCE1 acetyl...
Source: Experimental and Therapeutic Medicine - April 4, 2019 Category: General Medicine Tags: Exp Ther Med Source Type: research

Codelivery of DOX and siRNA by folate-biotin-quaternized starch nanoparticles for promoting synergistic suppression of human lung cancer cells.
Authors: Li L, He S, Yu L, Elshazly EH, Wang H, Chen K, Zhang S, Ke L, Gong R Abstract In this paper, the self-assembled folate-biotin-quaternized starch nanoparticles (FBqS NPs) were used as carrier system of doxorubicin (DOX) and siRNAIGF1R for the codelivery of both into human lung adenocarcinoma cell lines (A549 cells) in vitro. The cytotoxicity, targeted ligand competition, cell proliferation inhibition, cellular uptake, endocytosis mechanism and target protein suppression of drug-loaded FBqS NPs were evaluated in detail. Compared with several other drug formulations under same condition, siRNAIGF1R/DOX/FBqS N...
Source: Drug Delivery - April 30, 2019 Category: Drugs & Pharmacology Tags: Drug Deliv Source Type: research

Overcoming multiple drug resistance in lung cancer using siRNA targeted therapy.
Abstract Among cancers, lung cancer is the most morbidity and mortality disease that is remaining the fatalist. Generally, there are multiple treatment procedures for lung cancer, such as surgery, immunotherapy, radiotherapy and chemotherapy. There is, therefore, an urgent need for more specified and efficient methods for treatment of lung cancer such as RNAi, which in combination with traditional therapies could silence genes that are involved in the drug resistance. These genes may either be motivators of apoptosis inhibition, EMT and DNA repair system promoters or a member of intracellular signaling pathways, s...
Source: Gene - July 9, 2019 Category: Genetics & Stem Cells Authors: Naghizadeh S, Mohammadi A, Baradaran B, Mansoori B Tags: Gene Source Type: research

GSE112429 HMGB1 and Alu-siRNA inhibit the growth of human lung tumor cells
Contributors : Warayupa Thompat ; Apiwat MutiranguraSeries Type : Expression profiling by arrayOrganism : Homo sapiensWe performed expression profiling using microarray technology. The expression profiling identified genes or mechanism potentially regulating the proliferation of human lung cancer cells by BoxA of HMGB1 and Alu-siRNA transfection. The RNAs of our experiment were hybridized with Agilent SurePrint G3 Human GE 8X60K, V3 Microarrays (Agilent ®).
Source: GEO: Gene Expression Omnibus - March 26, 2021 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research

A bivalent cyclic RGD-siRNA conjugate enhances the antitumor effect of apatinib via co-inhibiting VEGFR2 in non-small cell lung cancer xenografts
Drug Deliv. 2021 Dec;28(1):1432-1442. doi: 10.1080/10717544.2021.1937381.ABSTRACTThe vascular endothelial growth factor receptor 2 (VEGFR2) is considered to be a pivotal target for anti-tumor therapy against angiogenesis of non-small cell lung cancer (NSCLC). However, effective and low-toxicity targeted therapies to inhibit VEGFR2 are still lacking. Here, biRGD-siVEGFR2 conjugate comprising murine VEGFR2 siRNA and [cyclo(Arg-Gly-Asp-D-Phe-Lys)-Ahx]2-Glu-PEG-MAL (biRGD) peptide which selectively binds to integrin αvβ3 receptors expressing on neovascularization endothelial cell was synthesized. The anti-tumor activity and ...
Source: Drug Delivery - July 8, 2021 Category: Drugs & Pharmacology Authors: Lumin Liao Bohong Cen Guoxian Li Yuanyi Wei Zhen Wang Wen Huang Shuai He Yawei Yuan Aimin Ji Source Type: research

Biomacromolecule-mediated pulmonary delivery of siRNA and anti-sense oligos: challenges and possible solutions
Expert Rev Mol Med. 2021 Dec 15;23:e22. doi: 10.1017/erm.2021.25.ABSTRACTBiomacromolecules have gained much attention as biomedicine carriers in recent years due to their remarkable biophysical and biochemical properties including sustainability, non-toxicity, biocompatibility, biodegradability, long systemic circulation time and ability to target. Recent developments in a variety of biological functions of biomacromolecules and progress in the study of biological drug carriers suggest that these carriers may have advantages over carriers of synthetic materials in terms of half-life, durability, protection and manufacturin...
Source: Molecular Medicine - December 15, 2021 Category: Molecular Biology Authors: Yaseen Hussain Jing-Hao Cui Haroon Khan Pooyan Makvandi Waqas Alam Source Type: research

GSE196499 Gene expression (GeneChip) data from scramble- and CRMP2A siRNA-treated A549 cells.
Contributors : Aristeidis E Boukouris ; Evangelos D MichelakisSeries Type : Expression profiling by arrayOrganism : Homo sapiensWe sought to assess how temporary loss of the microtubule-associated protein CRMP2A could affect global gene expression in the A549 lung cancer cells.We used microarrays to identify differentially regulated genes when CRMP2A is temporarily removed from A549 cells using siRNA.
Source: GEO: Gene Expression Omnibus - May 1, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research

Edible and cation-free kiwi fruit derived vesicles mediated EGFR-targeted siRNA delivery to inhibit multidrug resistant lung cancer
Clinically, activated EGFR mutation associated chemo-drugs resistance has severely threaten NSCLC patients. Nanoparticle based small interfering RNA (siRNA) therapy representing another promising alternative b...
Source: Journal of Nanobiotechnology - February 5, 2023 Category: Nanotechnology Authors: Haoying Huang, Xiaohan Yi, Qingyun Wei, Mengyuan Li, Xueting Cai, Yan Lv, Ling Weng, Yujie Mao, Weiwei Fan, Mengmeng Zhao, Zhongpei Weng, Qing Zhao, Kewei Zhao, Meng Cao, Jing Chen and Peng Cao Tags: Research Source Type: research