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Cancer: Hepatocellular Carcinoma

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Seventeen Years of Pediatric Liver Transplantation Experience for Cirrhosis and Hepatocellular Carcinoma
CONCLUSIONS: Hepatocellular carcinoma was mainly associated with inherited liver diseases in our pediatric series. Liver transplant provided a long-term survival advantage to pediatric patients with preexisting cirrhosis and hepatocellular carcinoma.PMID:35297328 | DOI:10.6002/ect.2021.0469
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - March 17, 2022 Category: Transplant Surgery Authors: Figen Özçay Oya Balci Sezer Faik Sarialio ğlu Fatih Boyvat Mehmet Co şkun Nihan Haberal Reyhan Mehmet Haberal Source Type: research

Autophagopathies: from autophagy gene polymorphisms to precision medicine for human diseases
Autophagy. 2022 Apr 6:1-18. doi: 10.1080/15548627.2022.2039994. Online ahead of print.ABSTRACTAt a time when complex diseases affect globally 280 million people and claim 14 million lives every year, there is an urgent need to rapidly increase our knowledge into their underlying etiologies. Though critical in identifying the people at risk, the causal environmental factors (microbiome and/or pollutants) and the affected pathophysiological mechanisms are not well understood. Herein, we consider the variations of autophagy-related (ATG) genes at the heart of mechanisms of increased susceptibility to environmental stress. A c...
Source: Autophagy - April 6, 2022 Category: Cytology Authors: Iris Grosjean Barnab é Roméo Marie-Angela Domdom Amine Belaid Gr égoire D'Andréa Nicolas Guillot Romain K Gherardi Jocelyn Gal G érard Milano Charles Hugo Marquette Rayjean J Hung Maria Teresa Landi Younghun Han Patrick Brest Martin Von Bergen Daniel Source Type: research

Model-guided therapy for hepatocellular carcinoma: a role for information technology in predictive, preventive and personalized medicine
This article reviews a rationale and method for combining and integrating diagnostic and therapeutic management with information technology (IT), in a manner that supports patients through their continuum of care. It is imperative that any program devised to explore and develop personalized health care delivery must be firmly rooted in clinically confirmed and accepted principles and technologies. Therefore, a use case, relating to hepatocellular carcinoma (HCC), was developed. The approach to the management of medical information we have taken is based on model theory and seeks to implement a form of model-guided therapy ...
Source: EPMA Journal - September 23, 2014 Category: Global & Universal Source Type: research

Molecules, Vol. 21, Pages 82: A New Bioactive Metabolite Isolated from the Red Sea Marine Sponge Hyrtios erectus
Chemical investigation of the lipophilic fraction of Hyrtios erectus, a Red Sea sponge, yielded a new pentacyclic nitrogen-containing scalarane; 24-methoxypetrosaspongia C (1), together with the previously reported scalaranes sesterstatin 3 (2), 12-deacetyl-12-epi-scalaradial (3) and 12-deacetyl-12,18-di-epi-scalaradial (4). The compounds were identified using HRESIMS, 1D and 2D NMR experiments. The isolated compounds showed growth inhibitory activity against hepatocellular carcinoma (HepG2), colorectal carcinoma (HCT-116) and breast adenocarcinoma cells (MCF-7).
Source: Molecules - January 15, 2016 Category: Chemistry Authors: Sameh ElhadyAli El-HalawanyAbdulrahman AlahdalHashim HassaneanSafwat Ahmed Tags: Article Source Type: research

Top Companies in Genomics
From portable genome sequencers until genetic tests revealing distant relations with Thomas Jefferson, genomics represents a fascinatingly innovative area of healthcare. As the price of genome sequencing has been in free fall for years, the start-up scene is bursting from transformative power. Let’s look at some of the most amazing ventures in genomics! The amazing journey of genome sequencing Genome sequencing has been on an amazing scientific as well as economic journey for the last three decades. The Human Genome Project began in 1990 with the aim of mapping the whole structure of the human genome and sequencing it. ...
Source: The Medical Futurist - May 30, 2017 Category: Information Technology Authors: nora Tags: Genomics Personalized Medicine AI artificial intelligence bioinformatics cancer DNA dna testing DTC gc3 genetic disorders genetics genome sequencing personal genomics precision medicine Source Type: blogs

Cytotoxic activity of alkyl benzoate and fatty acids from the red sea sponge Hyrtios erectus.
Abstract The chemical investigation of the methylene chloride fraction of marine sponge Hyrtios erectus led to the isolation of the known oxysterol (2) along with a new alkyl benzoate compound identified by spectroscopic methods (NMR and MS) as 4'-methylheptyl benzoate (1), whilst the n-butanol fraction afforded the known indole 3-carbaldehyde and β-carboline derivatives. Moreover, the hexane fraction was analysed by GC-MS for their fatty acids (FAs). A total of 17 FAs with chain lengths between 14 and 25 carbons were identified. Methyl-branched FAs are predominated suggesting the presence of bacterial symbionts...
Source: Natural Product Research - July 3, 2017 Category: Biochemistry Authors: Hawas UW, Abou El-Kassem LT, Abdelfattah MS, Elmallah MIY, Eid MAG, Monier M, Nithiyanandam M Tags: Nat Prod Res Source Type: research

Mutant CTNNB1 and histological heterogeneity define metabolic subtypes of hepatoblastoma
Abstract Hepatoblastoma is the most common malignant pediatric liver cancer. Histological evaluation of tumor biopsies is used to distinguish among the different subtypes of hepatoblastoma, with fetal and embryonal representing the two main epithelial components. With frequent CTNNB1 mutations, hepatoblastoma is a Wnt/β‐catenin‐driven malignancy. Considering that Wnt activation has been associated with tumor metabolic reprogramming, we characterized the metabolic profile of cells from hepatoblastoma and compared it to cells from hepatocellular carcinoma. First, we demonstrated that glucose transporter GLUT3 is a direc...
Source: EMBO Molecular Medicine - September 1, 2017 Category: Molecular Biology Authors: Stefania Crippa, Pierre ‐Benoit Ancey, Jessica Vazquez, Paolo Angelino, Anne‐Laure Rougemont, Catherine Guettier, Vincent Zoete, Mauro Delorenzi, Olivier Michielin, Etienne Meylan Tags: Research Article Source Type: research

Phylogenetic Analysis and Biological Evaluation of Marine Endophytic Fungi Derived from Red Sea Sponge Hyrtios erectus.
Abstract Forty-four endophytic fungal isolates obtained from marine sponge, Hyrtios erectus, were evaluated and screened for their hydrolase activities. Most of the isolates were found to be prolific producers of hydrolytic enzymes. Only 11 isolates exhibited maximum cellular contents of lipids, rhamnolipids, and protein in the fungal isolates under the isolation numbers MERVA5, MERVA22, MERVA25, MERVA29, MERVA32, MERVA34, MERV36, MERVA39, MERVA42, MERVA43, and MERVA44. These isolate extracts exhibit the highest reducing activities against carbohydrate-metabolizing enzymes including α-amylase, α-glucosidase, β-...
Source: Applied Biochemistry and Biotechnology - January 12, 2018 Category: Biochemistry Authors: El-Gendy MMAA, Yahya SMM, Hamed AR, Soltan MM, El-Bondkly AMA Tags: Appl Biochem Biotechnol Source Type: research

A novel oncogene URG4/URGCP and its role in cancer.
Abstract Oncogenes are mutated form of normal cellular genes called as proto-oncogenes and conduce to the cancer development process. Despite the fact that so many genes have been described, new genes with oncogenic characteristic and potential or tumor supressoring activity are still being defined. Recently, Up-regulated gene 4/Upregulator of cell proliferation (URG4/URGCP), a novel gene, induced by hepatitis-Bvirus-encoded X antigen (HBxAg), has been identified. URG4/URGCP gene was registered to the National Center for Biotechnology Information-GenBank (NCBI-GenBank, Entrez GeneID: 55665 and Entrez Nucleotide ID...
Source: Gene - May 15, 2018 Category: Genetics & Stem Cells Authors: Dodurga Y, Seçme M, Lale Şatıroğlu-Tufan N Tags: Gene Source Type: research

Persistent cholestasis resulting from duodenal papillary carcinoma in an adolescent male: A case report
Conclusion: Cholestasis resulting from primary duodenal papillary carcinoma is rare in pediatric patients but should be considered in the differential diagnosis.
Source: Medicine - May 1, 2019 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research