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Specialty: Biochemistry
Cancer: Adenocarcinoma

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Total 32 results found since Jan 2013.

Ro60/SSA levels are increased and promote the progression of pancreatic ductal adenocarcinoma.
Abstract Ro60/SSA is a vital auto antigen that is targeted in Sjogren's syndrome and systemic lupus erythematosus (SLE). However, its role in solid cancers has rarely been reported. The present study investigated the expression and function of Ro60/SSA in the development of pancreatic ductal adenocarcinoma (PDAC) both in vitro and in vivo. Immunohistochemistry was used to examine the expression of Ro60/SSA in PDAC and normal pancreatic tissues by using tissue microarray chips. The results showed that Ro60/SSA expression was increased in PDAC tissues compared with normal pancreatic tissues. Knockdown of Ro60/SSA by...
Source: Biochemical and Biophysical Research communications - December 21, 2017 Category: Biochemistry Authors: Liu D, Qian W, Li D, Kong L Tags: Biochem Biophys Res Commun Source Type: research

The long non-coding RNA MALAT1 activates Nrf2 signaling to protect human umbilical vein endothelial cells from hydrogen peroxide.
Abstract The potential effect of the long non-coding RNA (lncRNA) metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) against hydrogen peroxide (H2O2)-induced oxidative injury in endothelial cells was tested. We show that forced-expression of MALAT1 using a lentiviral vector ("LV-MALAT1") significantly attenuated H2O2-induced death and apoptosis of human umbilical vein endothelial cells (HUVECs). Conversely, knocking down of MALAT1 by targeted siRNA exacerbated H2O2-induced HUVEC injury. For the mechanism study, we show that LV-MALAT1 induced Keap1 downregulation, leading to nuclear-factor-E2-related f...
Source: Biochemical and Biophysical Research communications - December 20, 2017 Category: Biochemistry Authors: Zeng R, Zhang R, Song X, Ni L, Lai Z, Liu C, Ye W Tags: Biochem Biophys Res Commun Source Type: research

Effects of long noncoding RNA SPRY4 ‐IT1‐mediated EZH2 on the invasion and migration of lung adenocarcinoma
This article is protected by copyright. All rights reserved
Source: Journal of Cellular Biochemistry - August 10, 2017 Category: Biochemistry Authors: Xin Wen, Xin ‐Rui Han, Yong‐Jian Wang, Shao‐Hua Fan, Juan Zhuang, Zi‐Feng Zhang, Qun Shan, Meng‐Qiu Li, Bin Hu, Chun‐Hui Sun, Qiao Wu, Jun‐Hua Tan, Dong‐Mei Wu, Jun Lu, Yuan‐Lin Zheng Tags: Article Source Type: research

Role of CCL20 mediated immune cell recruitment in NF- κB mediated TRAIL resistance of pancreatic cancer.
In conclusion, our data show a functional role of a RelA-CCL20 pathway in PDAC TRAIL resistance. We demonstrate how the therapy-induced cross-talk of cancer cells with immune cells affects treatment responses, knowledge needed to tailor novel bi-specific treatments, which target tumor cell as well as immune cells. PMID: 28188806 [PubMed - as supplied by publisher]
Source: Biochimica et Biophysica Acta - February 6, 2017 Category: Biochemistry Authors: Geismann C, Grohmann F, Dreher A, Häsler R, Rosenstiel P, Legler K, Hauser C, Egberts JH, Sipos B, Schreiber S, Linkermann A, Hassan Z, Schneider G, Schäfer H, Arlt A Tags: Biochim Biophys Acta Source Type: research

MiR-216a decreases MALAT1 expression, induces G2/M arrest and apoptosis in pancreatic cancer cells.
Abstract How lncRNA MALAT1 is regulated by miRNAs at posttranscriptional level in pancreatic cancer and their regulative effects on the cancer cells remain largely unknown. By retrieving previous miRNA array data and performing primary qRT-PCR, we observed a significant negative correlation between miR-216a and MALAT1 in pancreatic ductal adenocarcinoma (PDAC) tissues and adjacent normal tissues. The following in vitro cell assay further confirmed a direct binding between miR-216a and MALAT1 and the suppressive effect of miR-216a on MALAT1 expression. MiR-216a overexpression had similar effects as MALAT1 siRNA on ...
Source: Biochemical and Biophysical Research communications - December 25, 2016 Category: Biochemistry Authors: Zhang Y, Tang X, Shi M, Wen C, Shen B Tags: Biochem Biophys Res Commun Source Type: research

Paracrine IL-6 signaling mediates the effects of pancreatic stellate cells on epithelial-mesenchymal transition via Stat3/Nrf2 pathway in pancreatic cancer cells
Conclusions IL-6 from PSC promotes EMT in PDAC cells via Stat3/Nrf2 pathway. General significance Targeting Stat3/Nrf2 pathway activated by PSC-secreted IL-6 may provide a novel therapeutic option to improve the prognosis of PDAC.
Source: Biochimica et Biophysica Acta (BBA) General Subjects - December 2, 2016 Category: Biochemistry Source Type: research

FoxM1 inhibition enhances chemosensitivity of docetaxel-resistant A549 cells to docetaxel via activation of JNK/mitochondrial pathway.
Abstract Docetaxel is recommended as a second-line chemotherapy agent for the non-small-cell lung cancer (NSCLC); however, drug resistance greatly limits its efficiency. Forkhead box M1 (FoxM1), an oncogenic transcription factor, is believed to be involved in the chemoresistance of various human cancers; whereas the association of FoxM1 with acquired docetaxel-resistance in NSCLC remains unclear. In the present study, we investigated the involvement of FoxM1 in the docetaxel-resistant human lung adenocarcinoma A549 cells (A549/DTX). Our results showed that FoxM1 expression was significantly increased in the A549/D...
Source: Acta Biochimica et Biophysica Sinica - August 11, 2016 Category: Biochemistry Authors: Wang K, Zhu X, Zhang K, Zhu L, Zhou F Tags: Acta Biochim Biophys Sin (Shanghai) Source Type: research

PlGF knockdown inhibited tumor survival and migration in gastric cancer cell via PI3K/Akt and p38MAPK pathways
The molecular signalling of placental growth factor (PlGF), a member of the vascular endothelial growth factor family, was not uncovered in human adenocarcinoma gastric cell line (AGS). The purpose of this study was to examine the inhibitory effects of PlGF knockdown on cell proliferation, apoptosis and migration through p38 mitogen‐activated protein kinase (p38MAPK) and PI3K pathways in human adenocarcinoma gastric cell line (AGS). To study PlGF knockdown effect, AGS cells were treated with 40 pmol of small interfering RNA (siRNA) related to PlGF gene and also a scrambled siRNA as control. Trypan Blue and Anexin V sta...
Source: Cell Biochemistry and Function - March 1, 2016 Category: Biochemistry Authors: Hassan Akrami, Fatemeh Mahmoodi, Somaye Havasi, Amene Sharifi Tags: Research Article Source Type: research

Enhanced Expression of Fibroblast Growth Factor Receptor 3 IIIc Promotes Human Esophageal Carcinoma Cell Proliferation
Deregulated expression of fibroblast growth factor receptors (FGFRs) and their ligands plays critical roles in tumorigenesis. The gene expression of an alternatively spliced isoforms of FGFR3, FGFR3IIIc, was analyzed by RT-PCR in samples from patients with esophageal carcinoma (EC), including esophageal squamous cell carcinoma (ESCC) and adenocarcinoma (EAC). The incidence of FGFR3IIIc was higher in EC [12/16 (75%); p=0.073] than in non-cancerous mucosa (NCM) [6/16 (38%)]. Indeed, an immunohistochemical analysis of early-stage ESCC showed that carcinoma cells expressing FGFR3IIIc stained positively with SCC-112, a tumor ma...
Source: Journal of Histochemistry and Cytochemistry - December 29, 2015 Category: Biochemistry Authors: Ueno, N., Shimizu, A., Kanai, M., Iwaya, Y., Ueda, S., Nakayama, J., Seo, M. K. Tags: Articles Source Type: research

NF45 overexpression is associated with poor prognosis and enhanced cell proliferation of pancreatic ductal adenocarcinoma.
In this study, we investigated the clinical relevance and potential role of NF45 expression in PDAC development. Western blot analysis revealed that NF45 was remarkably upregulated in PDAC tissues, compared with the adjacent non-tumorous ones. In addition, the expression of NF45 in 122 patients with PDAC was evaluated using immunohistochemistry. In this way, we found that NF45 was abundantly expressed in PDAC tissues, and the expression of NF45 was correlated with tumor size (p = 0.007), histological differentiation (p = 0.033), and TNM stage (p = 0.001). Importantly, patients with low levels of NF45 expression exhib...
Source: Molecular and Cellular Biochemistry - August 15, 2015 Category: Biochemistry Authors: Wan C, Gong C, Ji L, Liu X, Wang Y, Wang L, Shao M, Yang L, Fan S, Xiao Y, Wang X, Li M, Zhou G, Zhang Y Tags: Mol Cell Biochem Source Type: research

Up-regulation of fatty acid synthase induced by EGFR/ERK activation promotes tumor growth in pancreatic cancer.
Abstract Lipid metabolism is dysregulated in many human diseases including atherosclerosis, type 2 diabetes and cancers. Fatty acid synthase (FASN), a key lipogenic enzyme involved in de novo lipid biosynthesis, is significantly upregulated in multiple types of human cancers and associates with tumor progression. However, limited data is available to understand underlying biological functions and clinical significance of overexpressed FASN in pancreatic ductal adenocarcinoma (PDAC). Here, upregulated FASN was more frequently observed in PDAC tissues compared with normal pancreas in a tissue microarray. Kaplan-Meie...
Source: Biochemical and Biophysical Research communications - June 1, 2015 Category: Biochemistry Authors: Bian Y, Yu Y, Wang S, Li L Tags: Biochem Biophys Res Commun Source Type: research

Identification of anti-metastatic drug and natural compound targets in isogenic colorectal cancer cells.
Abstract Therapeutic strategies for cancer treatment often remain challenging due to the cumulative risk derived from metastasis, which has been described as an aggressive state of cancer cell proliferation often resulting in failure of clinical therapy. In the current study, anti-metastatic properties of three chemotherapeutic drugs and three compounds from natural sources were investigated by comparative proteomic analysis. Proteomic profile comparison of the isogenic primary and metastatic colon cancer cell lines SW480 and SW620 identified two potential metastasis related molecular targets: fatty acid synthase ...
Source: Journal of Proteomics - October 23, 2014 Category: Biochemistry Authors: Lee JG, McKinney KQ, Pavlopoulos AJ, Park JH, Hwang S Tags: J Proteomics Source Type: research

Proteomic signatures associated with p53 mutational status in lung adenocarcinoma
This article is protected by copyright. All rights reserved
Source: Proteomics - October 21, 2014 Category: Biochemistry Authors: Ayumu Taguchi, Oliver Delgado, Müge Çeliktaş, Hiroyuki Katayama, Hong Wang, Adi F. Gazdar, Samir M. Hanash Tags: Research Article Source Type: research

Antitumor effects of the flavone chalcone: inhibition of invasion and migration through the FAK/JNK signaling pathway in human gastric adenocarcinoma AGS cells.
In this study, we first report the chemopreventive effect of chalcone in human gastric adenocarcinoma cell lines: AGS. The results showed that chalcone could inhibit the abilities of the adhesion, invasion, and migration by cell-matrix adhesion assay, Boyden chamber invasion/migration assay, and wound-healing assay. Molecular data showed that the effect of chalcone in AGS cells might be mediated via sustained inactivation of the phosphorylation of focal adhesion kinase (FAK) and c-Jun N-terminal kinase 1 and 2 (JNK1/2) signal involved in the downregulation of the expressions of matrix metalloproteinase-2 (MMP-2) and matrix...
Source: Molecular and Cellular Biochemistry - February 9, 2014 Category: Biochemistry Authors: Lin SH, Shih YW Tags: Mol Cell Biochem Source Type: research

BI-1 enhances Fas-induced cell death through a Na+/H+-associated mechanism.
This study was designed to investigate the effect of BI-1 on Fas-induced cell death and the underlying mechanisms. HT1080 adenocarcinoma cells were transfected with vector alone (Neo cells) or BI-1-vector (BI-1 cells) and treated with Fas. The BI-1 cells showed enhanced sensitivity to Fas in cell viability, apoptosis, and caspase-3 analyses. Fas significantly decreased cytosolic pH in BI-1 cells, which correlated with BI-1 oligomerization, mitochondrial Ca(2+) accumulation, and significant inhibition of sodium-hydrogen exchanger (NHE) activity compared with Neo cells. A single treatment with the NHE inhibitor EIPA or siRNA...
Source: BMB Reports - December 7, 2013 Category: Biochemistry Authors: Lee GH, Kim HR, Chae HJ Tags: BMB Rep Source Type: research