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Cancer: Brain Cancers

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Total 92 results found since Jan 2013.

Effect of intravenous thrombolysis with alteplase on clinical efficacy, inflammatory factors, and neurological function in patients with acute cerebral infarction
This study aimed to explore the effect of intravenous thrombolysis with alteplase on clinical efficacy, inflammatory factors, and neurological function in patients with acute cerebral infarction. A total of 120 patients with acute cerebral infarction were divided into two groups by the random number table method, with 60 patients in each group: observation group (intravenous thrombolysis with alteplase) and control group (intravenous thrombolysis with batroxobin). The clinical efficacy after a 14-day treatment was observed. Serum C-reactive protein (CRP), tumor necrosis factor α (TNF-α), interleukin-6 (IL-6), CD62p, GMP-...
Source: Brazilian Journal of Medical and Biological Research - March 17, 2021 Category: Research Authors: Jinhua Wang Xia Fang Dongliang Wang Yuan Xiao Source Type: research

Mitochondrial –nuclear p53 trafficking controls neuronal susceptibility in stroke
AbstractStroke is a major cause of death and long ‐term disability in the adult. Neuronal apoptosis plays an essential role in the pathophysiology of ischemic brain damage and impaired functional recovery after stroke. The tumor suppressor protein p53 regulates key cellular processes, including cell cycle arrest, DNA repair, senescence, and apopt osis. Under cellular stress conditions, p53 undergoes post‐translational modifications, which control protein localization, stability, and proapoptotic activity. After stroke, p53 rapidly accumulates in the ischemic brain, where it activates neuronal apoptosis through both tra...
Source: IUBMB Life - March 2, 2021 Category: Research Authors: Angeles Almeida, Irene S ánchez‐Morán, Cristina Rodríguez Tags: CRITICAL REVIEW Source Type: research

SI – CROSSTALK: Mitochondrial‐nuclear p53 trafficking controls neuronal susceptibility in stroke
SUMMARYStroke is a major cause of death and long ‐term disability in the adult. Neuronal apoptosis plays an essential role in the pathophysiology of ischemic brain damage and the impaired functional recovery after stroke. The tumor suppressor protein p53 regulates key cellular processes, including cell cycle arrest, DNA repair, senescence, and a poptosis. Under cellular stress conditions, p53 undergoes post‐translational modifications, which controls protein localization, stability, and pro‐apoptotic activity. After stroke, p53 rapidly accumulates in the ischemic brain, where it activates neuronal apoptosis, through ...
Source: IUBMB Life - February 22, 2021 Category: Research Authors: Angeles Almeida, Irene S ánchez‐Morán, Cristina Rodríguez Tags: CRITICAL REVIEW Source Type: research

Mitochondrial ‐nuclear p53 trafficking controls neuronal susceptibility in stroke
SUMMARYStroke is a major cause of death and long ‐term disability in the adult. Neuronal apoptosis plays an essential role in the pathophysiology of ischemic brain damage and the impaired functional recovery after stroke. The tumor suppressor protein p53 regulates key cellular processes, including cell cycle arrest, DNA repair, senescence, and a poptosis. Under cellular stress conditions, p53 undergoes post‐translational modifications, which controls protein localization, stability, and pro‐apoptotic activity. After stroke, p53 rapidly accumulates in the ischemic brain, where it activates neuronal apoptosis, through ...
Source: IUBMB Life - February 21, 2021 Category: Research Authors: Angeles Almeida, Irene S ánchez‐Morán, Cristina Rodríguez Tags: CRITICAL REVIEW Source Type: research

Efficacy of Beraprost Sodium Combined with Sildenafil and Its Effects on Vascular Endothelial Function and Inflammation in Patients Experiencing Left Heart Failure Complicated with Pulmonary Arterial Hypertension.
CONCLUSIONS Beraprost sodium combined with sildenafil for left heart failure complicated with pulmonary arterial hypertension can effectively improve pulmonary arterial hypertension, alleviate left heart failure, and reduce inflammatory responses, thereby achieving better clinical efficacy in patients. PMID: 33531453 [PubMed - in process]
Source: Medical Science Monitor - February 5, 2021 Category: Research Tags: Med Sci Monit Source Type: research

DPP-4 inhibitor saxagliptin ameliorates oxygen deprivation/reoxygenation-induced brain endothelial injury.
In this study, we reveal that saxagliptin, one of the most widely used DPP-4 inhibitors, exhibits vascular protective effects against oxygen and glucose depletion/reoxygenation (OGD/R) in human brain vascular endothelial cells. Our data show that DPP-4 is fairly expressed in brain endothelial cells and its expression is induced by OGD/R. The results of MTT assay show that inhibition of DPP-4 by saxagliptin ameliorates OGD/R-induced reduced cell viability, and LDH assay demonstrated that saxagliptin reduces cellular toxicity. Furthermore, we show that saxagliptin mitigates OGD/R-induced collapse of mitochondrial membrane po...
Source: American Journal of Translational Research - November 20, 2019 Category: Research Tags: Am J Transl Res Source Type: research

Cerebellar Fastigial Nucleus Stimulation in a Chronic Unpredictable Mild Stress Rat Model Reduces Post-Stroke Depression by Suppressing Brain Inflammation via the microRNA-29c/TNFRSF1A Signaling Pathway.
CONCLUSIONS In a rat model, cerebellar fastigial nucleus stimulation reduced the expression of TNFRSF1A by upregulating miR-29c expression, which suppressed the expression of inflammatory cytokines, resulting in reduced severity of post-stroke depression. PMID: 31352465 [PubMed - in process]
Source: Medical Science Monitor - July 30, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Ovarian Cancer Presenting as Cryptogenic Stroke from Patent Foramen Ovale.
Abstract A 52-year-old woman experienced severe headache, confusion, nausea, dizziness, and diplopia for three days. Magnetic resonance imaging of the brain showed multiple acute and subacute infarcts suggestive of embolic events. Dermatological examination was notable for splinter hemorrhages and macular patches on the fingernails and feet, respectively. Further diagnostic imaging of the chest and abdomen revealed pulmonary emboli and an ovarian mass with omental deposits and splenic infarcts. Fine needle aspiration cytology and surgery confirmed a diagnosis of high grade serous adenocarcinoma of the ovary with c...
Source: Clin Med Res - July 18, 2019 Category: Research Authors: Potugari BR, Priyanka P, Komanapalli SD, Mercier RJ Tags: Clin Med Res Source Type: research

Non-Invasive In Vivo MRI Method to Image Salient Features of Axons and Nerves
The invention from Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) provides a non-invasive, painless means for measuring microanatomical features of Nerve and Axon Diameter Distribution (ADD) to image the Central and Peripheral Nervous Systems (CNS and PNS). ADD is altered in abnormal development (e.g., autism), in neurodegenerative processes (e.g., aging, alcoholism, Alzheimer ’s disease) and diseases such as ALS (Lou Gehrig’s disease). U.S. patent 7,643,863, related to this invention, consists of a novel diffusion Magnetic Resonance Imaging (MRI) experiment and modeling framew...
Source: NIH OTT Licensing Opportunities - November 14, 2018 Category: Research Authors: ajoyprabhu3 Source Type: research

Isotropic Generalized Diffusion Tensor MRI
Scientists at the Eunice Kennedy Shriver National Institute for Child Health and Human Development (NICHD) have developed a method implemented as pulse sequences and software to be used with magnetic resonance imaging (MRI) scanners and systems. This technology is available for licensing and commercial development. The method allows for measuring and mapping features of the bulk or average apparent diffusion coefficient (ADC) of water in tissue – aiding in stroke diagnosis and cancer therapy assessment. The pulse sequences and software enable MRI scanners to yield diffusion weighted images (DWI) that are orientationally ...
Source: NIH OTT Licensing Opportunities - August 16, 2018 Category: Research Authors: ajoyprabhu3 Source Type: research

Metallomics Applied to the  Study of Neurodegenerative and Mental Diseases.
Metallomics Applied to the Study of Neurodegenerative and Mental Diseases. Adv Exp Med Biol. 2018;1055:21-37 Authors: Sussulini A, Hauser-Davis RA Abstract Biochemical imbalances, provoked by aging or a secondary illness, might directly affect the brain, causing severe problems, such as loss of memory or alteration of behavior patterns. Brain disorders are usually classified as injuries (such as stroke, hematomas, and concussions), tumors, and neurodegenerative (such as Parkinson's and Alzheimer's diseases) and mental (such as depression, bipolar disorder, schizophrenia) diseases. As the pathophysiolo...
Source: Advances in Experimental Medicine and Biology - June 11, 2018 Category: Research Tags: Adv Exp Med Biol Source Type: research

Novel Magnetic Resonance Spectroscopy (MRS) Technique to Quantify Brain Metabolites
With respect to quantification of metabolites in the brain, conventional methods of magnetic resonance spectroscopy (MRS) yield results that are highly variable and highly dependent on the sequence type being applied. This invention describes a novel MRS technique that involves preparing longitudinal steady states at different flip angles using trains of RF pulses interspersed with field gradients to quantify metabolites. The method allows quantification of metabolites and their relaxation rates under specified parameters, which may create new ways of analyzing and interpreting tissue properties or identifying and characte...
Source: NIH OTT Licensing Opportunities - May 23, 2018 Category: Research Authors: ajoyprabhu3 Source Type: research

Memantine protects against ischemia/reperfusion ‐induced brain endothelial permeability
In conclusion, our results identified a novel function of memantine in maintaining brain vascular barrier function and suggested that memantine might be a potential therapeutic agent for the treatment of stroke. © 2018 IUBMB Life, 2018
Source: IUBMB Life - March 15, 2018 Category: Research Authors: Yingying Liu, Yudiao Huang, Yueyue Xu, Peng Qu, Minghua Wang Tags: Research Communication Source Type: research