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Bm-19 * symptomatic and economic burden of brain metastases in patients with alk+ nsclc
CONCLUSIONS: BM presents a substantial symptomatic and economic burden in patients with ALK+ NSCLC. Given the large percentage of ALK+ NSCLC patients who will eventually develop BM, this highlights an important unmet need.
Source: Neuro-Oncology - November 3, 2014 Category: Cancer & Oncology Authors: Macalalad, A., Sasane, M., Zhang, J., Culver, K., Dea, K., Nitulescu, R., Wu, E., Guerin, A. Tags: BRAIN METASTASES (CLINICAL AND/OR LABORATORY RESEARCH) Source Type: research

Periodic Lateralized Epileptiform Discharges (PLEDs) in Patients With Neurosyphilis and HIV Infection.
Abstract Periodic lateralized epileptiform discharges (PLEDs) are an electroencephalographic pattern recorded in the setting of a variety of brain abnormalities. It is best recognized for its association with acute viral encephalitis, stroke, tumor, or latestatus epilepticus. However, there are other conditions that have been recognized as the underlying pathology for PLEDs such as alcohol withdrawal, Creutzfeldt-Jacob disease, anoxic brain injury, and hemiplegic migraine. However, there are only rare case reports of PLEDs in patients with neurosyphilis. Here, we report 2 patients presenting with encephalopathy an...
Source: Clinical EEG and Neuroscience - October 17, 2014 Category: Neuroscience Authors: Takagaki K, Morales MK, Vitantonio D, Berkowitz F, Bell WL, Kumar PN, Motamedi GK Tags: Clin EEG Neurosci Source Type: research

The Case Files: Unusual Headache
By Al-Hashimi, Siddhartha DO; Leavens, John MD A 23-year-old woman with a history of migraine headaches presented to the emergency department for a different-than-usual headache. She had a six-day history of intermittent headaches. The onset was at rest, and there was no history of trauma.   The headache was located behind her left eye, and it radiated into the posterior portion of her head. She characterized it as being 8/10 in intensity. Bright lights were reported as an exacerbating factor. The headache was associated with nausea and multiple episodes of emesis. She had 10 episodes of vomiting the evening prior to arri...
Source: The Case Files - June 5, 2014 Category: Emergency Medicine Tags: Blog Posts Source Type: research

A 12-Year-Old African American Girl With Subacute Bilateral Ophthalmoplegia
A twelve-year-old African-American female presented with two week history of progressively worsening headache and fatigue, and vision difficulties for the past week. The physical examination was normal. The neurological evaluation was normal, except for cranial nerves (CN) testing, which showed bilateral restriction of adduction (CN III) and up gaze (CN IV) motions, vertical nystagmus, and left side facial paresis of central origin (CN VII). The bilateral exotropia and ophthalmoplegia are characteristics of WEBINO (Wall-Eyed Bilateral Intranuclear Ophthalmoplegia) syndrome, associated to a brain stem structural lesion. The...
Source: Seminars in Pediatric Neurology - May 1, 2014 Category: Neurology Authors: Amir Bar, Jacqueline Urbine, Yasmine Bahora, Meghan Berkenstock, Jennifer Vodzak, Hamalatha Guruprasad, Manisha Sinha, Thair Abed, Agustín Legido Source Type: research

Headaches in brain tumor patients: primary or secondary?
CONCLUSION: Our literature review revealed that brain tumor headache uncommonly presents with classic brain tumor headache characteristics and often satisfies criteria for a primary headache category such as migraine or tension-type. Thus, clinicians may miss headaches due to brain tumors in following ICHD-3 criteria, and the distinction between primary and secondary headache disorders may not be so clear-cut. PMID: 24697234 [PubMed - in process]
Source: Headache - April 1, 2014 Category: Neurology Authors: Nelson S, Taylor LP Tags: Headache Source Type: research

Cerebral microbleeding in varicella-zoster viral meningitis: An early sign of vasculopathy?
A 75-year-old man undergoing chemotherapy for prostate cancer for 3 months presented with headache after having blisters in his left ear canal and auricle. His body temperature at presentation was 38°C. Neurologic examination revealed nuchal stiffness and left peripheral facial palsy. We also noted leukocytopenia (2,000/µL) and elevated serum C-reactive protein (8.51 mg/dL). CSF analysis showed no erythrocytes, elevated leukocytes (640/µL; 3% monocytes, 97% neutrophils), an increased protein level (473 mg/dL), and slightly decreased glucose level (51 mg/dL, serum glucose 120 mg/dL). Brain MRI and magnetic r...
Source: Neurology - March 3, 2014 Category: Neurology Authors: Ohtomo, R., Shirota, Y., Iwata, A., Shimizu, J., Tsuji, S. Tags: MRI, Other cerebrovascular disease/ Stroke, Vasculitis, Viral infections CLINICAL/SCIENTIFIC NOTES Source Type: research

Malignant Paraganglioma Presenting With Hemorrhagic Stroke in a Child
We report here the case of a 12-year-old boy with malignant sympathetic paraganglioma presenting with hemorrhagic stroke. Severe hypertension was found and the patient evolved into a coma. Brain computed tomography scan showed right thalamus hemorrhage with intraventricular extension. After clinical improvement, further investigation revealed elevated catecholamine and metanephrine levels, and 2 abdominal tumors were identified by computed tomography. Resection of both lesions was performed, and histologic findings were consistent with paraganglioma. Multiple metastatic involvement of bones and soft tissues appeared severa...
Source: PEDIATRICS - December 2, 2013 Category: Pediatrics Authors: Luiz, H. V., da Silva, T. N., Pereira, B. D., Santos, J. G., Goncalves, D., Manita, I., Portugal, J. Tags: Case Report Source Type: research

A rare cause of headache-the importance of a tissue diagnosis and perseverance
A 64 year old diabetic hypertensive milkman presented in September 2011 with 4 months progressive constant right frontotemporal retro–orbital pain. It was worse at night affecting sleep with slight right field blurring and later vomiting. Full examination including blood pressure was normal with acuities 6/9. Tension type headache was considered. Initial brain CT was reported as normal. With concern about giant cell arteritis steroids were trialled although ESR was 8 and CRP 25 with no other clinical features: pain reduction was short–lived and temporal artery biopsy negative. Symptoms worsened despite analgesi...
Source: Journal of Neurology, Neurosurgery and Psychiatry - October 9, 2013 Category: Neurosurgery Authors: Defty, H., Cavazza, A., Warner, G. Tags: Immunology (including allergy), Cranial nerves, Headache (including migraine), Neurooncology, Pain (neurology), Stroke, Hypertension, CNS cancer, Ophthalmology, Pain (palliative care), Anxiety disorders (including OCD and PTSD), Radiology, Disability, Dru Source Type: research

A stroke mimic; focal neurological deficits in benign hereditary chorea?
Conclusion This case highlights the difficulties in assessing patients with new focal neurological symptoms in the presence of known, pre existing, neurological disease. It also serves to highlight how often erroneously progressive weakness is mislabelled as a ‘stroke’. Neurologists working together with acute physicians in liaison posts in MAU, provides a unique opportunity to improve overall recognition of neurological disease, and for patients potentially provides a more timely diagnostic work–up and the opportunity for early treatment.
Source: Journal of Neurology, Neurosurgery and Psychiatry - October 9, 2013 Category: Neurosurgery Authors: Maw, K., Johnston, J., Rowntree, C., Kalhan, A. Tags: Immunology (including allergy), Headache (including migraine), Movement disorders (other than Parkinsons), Neurooncology, Pain (neurology), Stroke, CNS cancer, Neuropathology, Radiology, Surgical diagnostic tests, Surgical oncology Association of Britis Source Type: research

Why acupuncture is giving sceptics the needle
Acupuncture has been prescribed by half of Britain's doctors, but after 3,000 clinical trials its efficacy remains unproven. So is the NHS making a grave error in supporting this ancient treatment?• Are vitamin pills a sham? Q&A with Dr. Paul OffitYou can't get crystal healing on the NHS. The Department of Health doesn't fund faith healing. And most doctors believe magnets are best stuck on fridges, not patients. But ask for a treatment in which an expert examines your tongue, smells your skin and tries to unblock the flow of life force running through your body with needles and the NHS will be happy to oblige.The govern...
Source: Guardian Unlimited Science - July 26, 2013 Category: Science Authors: David Derbyshire Tags: Culture Health Science and scepticism Features NHS Alternative medicine The Observer Source Type: news

Incidence and prevalence of treated epilepsy among poor health and low-income Americans
Conclusions: The Medicaid population has a high incidence and prevalence of epilepsy, in an order of magnitude greater than that reported in the US general population. This indigent population carries a disproportionate amount of the epilepsy burden and deserves more attention for its health care needs and support services.
Source: Neurology - May 20, 2013 Category: Neurology Authors: Kaiboriboon, K., Bakaki, P. M., Lhatoo, S. D., Koroukian, S. Tags: Cohort studies, Prevalence studies, Incidence studies, All Epilepsy/Seizures ARTICLE Source Type: research

Do severe headaches portend greater stroke risk following CRT for childhood brain tumor?
Children with brain tumors are more likely to survive, with survival rates improving consistently over several decades and well over 70% of patients now surviving 5 years from diagnosis.1 The vast majority of these children will become long-term survivors. As cure rates improve, a greater focus has been placed on enduring patient health after cancer treatment.
Source: Neurology - April 15, 2013 Category: Neurology Authors: Heyer, G. L., Mack, K. J. Tags: Childhood stroke, Pediatric headache, All Cerebrovascular disease/Stroke, Primary brain tumor, All Pediatric EDITORIALS Source Type: research

Headache as a risk factor for neurovascular events in pediatric brain tumor patients
Conclusions: Severe recurrent headache appears to be a risk factor or predictor for subsequent cerebral ischemia in pediatric brain tumor survivors treated with radiation. This finding has clinical implications for both monitoring survivors and targeting a specific population for primary stroke prevention.
Source: Neurology - April 15, 2013 Category: Neurology Authors: Kranick, S. M., Campen, C. J., Kasner, S. E., Kessler, S. K., Zimmerman, R. A., Lustig, R. A., Phillips, P. C., Beslow, L. A., Ichord, R., Fisher, M. J. Tags: Childhood stroke, Pediatric headache, All Cerebrovascular disease/Stroke, Primary brain tumor, All Pediatric ARTICLE Source Type: research

Pesticides and Parkinson's: UCLA researchers uncover further proof of a link
For several years, neurologists at UCLA have been building a case that a link exists between pesticides and Parkinson's disease. To date, paraquat, maneb and ziram — common chemicals sprayed in California's Central Valley and elsewhere — have been tied to increases in the disease, not only among farmworkers but in individuals who simply lived or worked near fields and likely inhaled drifting particles.   Now, UCLA researchers have discovered a link between Parkinson's and another pesticide, benomyl, whose toxicological effects still linger some 10 years after the chemical was banned by the U.S. Environment...
Source: UCLA Newsroom: Health Sciences - January 3, 2013 Category: Universities & Medical Training Source Type: news

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