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Cancer: Squamous Cell Carcinoma
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Total 19645 results found since Jan 2013.
TRIM32 promotes oral squamous cell carcinoma progression by enhancing FBP2 ubiquitination and degradation
Biochem Biophys Res Commun. 2023 Aug 18;678:165-172. doi: 10.1016/j.bbrc.2023.08.030. Online ahead of print.ABSTRACTThe aberrant expression of TRIM32, an E3 ubiquitin ligase, has been identified in multiple malignant cancer types. Nevertheless, the functional roles and detailed mechanisms of TRIM32 in oral squamous cell carcinoma (OSCC) remain to be elucidated. Here, we investigated TRIM32 expression and its functional role in OSCC. TRIM32 expression was consistently elevated in OSCC tissues, particularly in samples from patients with advanced clinical grades. Functionally, silencing TRIM32 dampened OSCC cell growth, migra...
Source: Biochemical and Biophysical Research communications - August 28, 2023 Category: Biochemistry Authors: Xiao Yang Haifeng Ma Min Zhang Renzhong Wang Xiaoyu Li Source Type: research
Evaluation of programmed cell death ligand 1 expression in a contemporary cohort of penile squamous cell carcinoma and its correlation with clinicopathologic and survival parameters: A study of 134 patients
CONCLUSIONS: Overall, PD-L1 expression is associated with high-grade and metastatic tumors. Lower PD-L1 expression is observed more frequently in HPV-associated (warty or basaloid) subtypes than in other, predominantly HPV-independent types. As a result, PD-L1 positivity, including higher expression, portends lower overall and cancer-specific survival. These data provide a rational for further investigating PD-L1-based immunotherapeutics in PC.PMID:37639681 | DOI:10.1093/ajcp/aqad107
Source: American Journal of Clinical Pathology - August 28, 2023 Category: Pathology Authors: Anandi Lobo Sourav K Mishra Shilpy Jha Ankit Tiwari Rahul Kapoor Shivani Sharma Seema Kaushal N Sri Kiranmai M Rakshitha Das Kamal P Peddinti Shailendra K Sharma Nitin Bhardwaj Samriti Arora Deepika Jain Ekta Jain Gauri Munjal Sayali Shinde Vipra Malik He Source Type: research
Headache rounds: Postural headache in a patient with squamous cell carcinoma
Headache. 2023 Aug 27. doi: 10.1111/head.14615. Online ahead of print.NO ABSTRACTPMID:37635384 | DOI:10.1111/head.14615
Source: Headache - August 28, 2023 Category: Neurology Authors: Sayi P Boddu Brent P Goodman Juliana H VanderPluym Source Type: research
Evaluation of programmed cell death ligand 1 expression in a contemporary cohort of penile squamous cell carcinoma and its correlation with clinicopathologic and survival parameters: A study of 134 patients
CONCLUSIONS: Overall, PD-L1 expression is associated with high-grade and metastatic tumors. Lower PD-L1 expression is observed more frequently in HPV-associated (warty or basaloid) subtypes than in other, predominantly HPV-independent types. As a result, PD-L1 positivity, including higher expression, portends lower overall and cancer-specific survival. These data provide a rational for further investigating PD-L1-based immunotherapeutics in PC.PMID:37639681 | DOI:10.1093/ajcp/aqad107
Source: American Journal of Clinical Pathology - August 28, 2023 Category: Pathology Authors: Anandi Lobo Sourav K Mishra Shilpy Jha Ankit Tiwari Rahul Kapoor Shivani Sharma Seema Kaushal N Sri Kiranmai M Rakshitha Das Kamal P Peddinti Shailendra K Sharma Nitin Bhardwaj Samriti Arora Deepika Jain Ekta Jain Gauri Munjal Sayali Shinde Vipra Malik He Source Type: research
Epithelial-to-mesenchymal transition status correlated with ultrastructural features, and TP53 mutation in patient-derived oral cancer cell lines
CONCLUSIONS: Cellular migratory properties are associated with cellular ultrastructure, epithelial-to-mesenchymal transition status and the status of TP53 mutation in the genome.PMID:37639153 | DOI:10.1007/s11033-023-08720-x
Source: Mol Biol Cell - August 28, 2023 Category: Molecular Biology Authors: Sushant S Navarange Sanjay M Bane Darshan Mehta Sanket Shah Sanjay Gupta Sanjeev K Waghmare Source Type: research
Evaluation of programmed cell death ligand 1 expression in a contemporary cohort of penile squamous cell carcinoma and its correlation with clinicopathologic and survival parameters: A study of 134 patients
CONCLUSIONS: Overall, PD-L1 expression is associated with high-grade and metastatic tumors. Lower PD-L1 expression is observed more frequently in HPV-associated (warty or basaloid) subtypes than in other, predominantly HPV-independent types. As a result, PD-L1 positivity, including higher expression, portends lower overall and cancer-specific survival. These data provide a rational for further investigating PD-L1-based immunotherapeutics in PC.PMID:37639681 | DOI:10.1093/ajcp/aqad107
Source: American Journal of Clinical Pathology - August 28, 2023 Category: Pathology Authors: Anandi Lobo Sourav K Mishra Shilpy Jha Ankit Tiwari Rahul Kapoor Shivani Sharma Seema Kaushal N Sri Kiranmai M Rakshitha Das Kamal P Peddinti Shailendra K Sharma Nitin Bhardwaj Samriti Arora Deepika Jain Ekta Jain Gauri Munjal Sayali Shinde Vipra Malik He Source Type: research
Headache rounds: Postural headache in a patient with squamous cell carcinoma
Headache. 2023 Aug 27. doi: 10.1111/head.14615. Online ahead of print.NO ABSTRACTPMID:37635384 | DOI:10.1111/head.14615
Source: Headache - August 28, 2023 Category: Neurology Authors: Sayi P Boddu Brent P Goodman Juliana H VanderPluym Source Type: research
MCTS1 enhances the proliferation of laryngeal squamous cell carcinoma via promoting OTUD6B-1 mediated LIN28B deubiquitination
In this study, we further explored the expression of potential interaction between MCTS1 and OTU domain-containing protein 6B (OTUD6B) and its influence on the ubiquitination and degradation of OTUD6B's substrate in LSCC. LSCC cell lines AMC-HN-8 and TU177 were utilized for assessing protein-protein interaction, protein degradation and tumor growth in vitro and in vivo. The results showed that MCTS1 interacts with OUTD6B isoform 1 (OTUD6B-1) in the cell lines. Higher OTUD6B-1 expression is associated with significantly shorter progression-free interval in LSCC patients. OTUD6B positively modulated the expression of cyclin ...
Source: Cell Research - August 27, 2023 Category: Cytology Authors: Binjuan Ma Xiaoquan Wei Shijie Zhou Mengsheng Yang Source Type: research
Prognostic and immunological role of cancer-associated fibroblasts-derived exosomal protein in esophageal squamous cell carcinoma
CONCLUSION: In conclusion, our study has successfully established a robust prognostic signature based on CAFs-derived exosomal proteins, which can serve as a reliable biomarker for predicting prognosis and evaluating the immune microenvironment in ESCC.PMID:37634448 | DOI:10.1016/j.intimp.2023.110837
Source: International Immunopharmacology - August 27, 2023 Category: Allergy & Immunology Authors: Zhiping Wang Mengyan Zhang Lingyun Liu Yan Yang Jianjian Qiu Yilin Yu Jiancheng Li Source Type: research
SART3, regulated by p53, is a biomarker for diagnosis, prognosis and immune infiltration in hepatocellular carcinoma
CONCLUSION: The findings of this study demonstrate the diagnostic and prognostic value of SART3 in HCC. SART3 may be associated with immune infiltration of Th2 cells and macrophages in HCC, highlighting its potential role in the development and progression of HCC.OBJECTIVE: This study aimed to investigate the role of Squamous cell carcinoma antigen recognized by T cells 3 (SART3) in hepatocellular carcinoma (HCC).METHODS: SART3 expression and prognostic value were analyzed in TCGA and GEO datasets. The diagnostic value and prognostic significance of SART3 were determined using immunohistochemistry in the Guangxi cohort. Th...
Source: Aging - August 26, 2023 Category: Biomedical Science Authors: Jusen Nong Kejian Yang Tianman Li Chenlu Lan Xin Zhou Junqi Liu Haixiang Xie Jianzhu Luo Xiwen Liao Guangzhi Zhu Tao Peng Source Type: research
A common 18F-FDG PET radiomic signature to predict survival in patients with HPV-induced cancers
Eur J Nucl Med Mol Imaging. 2023 Aug 26. doi: 10.1007/s00259-023-06320-2. Online ahead of print.ABSTRACTLocally advanced cervical cancer (LACC) and anal and oropharyngeal squamous cell carcinoma (ASCC and OPSCC) are mostly caused by oncogenic human papillomaviruses (HPV). In this paper, we developed machine learning (ML) models based on clinical, biological, and radiomic features extracted from pre-treatment fluorine-18-fluorodeoxyglucose positron emission tomography ([18F]-FDG PET) images to predict the survival of patients with HPV-induced cancers. For this purpose, cohorts from five institutions were used: two cohorts o...
Source: Molecular Medicine - August 26, 2023 Category: Molecular Biology Authors: Stephane Niyoteka Romain-David Seban Rahimeh Rouhi Andrew Scarsbrook Catherine Genestie Marion Classe Alexandre Carr é Roger Sun Agustina La Greca Saint-Esteven Cyrus Chargari Jack McKenna Garry McDermott Eirik Malinen Stephanie Tanadini-Lang Matthias Gu Source Type: research
Vulvar squamous cell carcinoma due to human papillomavirus type 11
Skin Res Technol. 2023 Aug;29(8):e13436. doi: 10.1111/srt.13436.NO ABSTRACTPMID:37632178 | DOI:10.1111/srt.13436
Source: Cell Research - August 26, 2023 Category: Cytology Authors: Pati Aji Achdiat Retno Hesty Maharani Nizami Hamada Reiva Farah Dwiyana Laila Tsaqilah Hermin Aminah Usman None Zulfan Source Type: research
