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Cancer: Squamous Cell Carcinoma

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Total 19037 results found since Jan 2013.

Minimally invasive surgery versus radiotherapy/chemoradiotherapy for small-volume primary oropharyngeal carcinoma.
CONCLUSIONS: The role of endoscopic head and neck surgery in the management of OPSCC is clearly expanding as evidenced by its more overt incorporation into the current National Comprehensive Cancer Network guidelines. Data are mounting regarding its outcomes both in terms of survival and lower morbidity. As confidence increases, it is being used in the management of more advanced OPSCC.Based on this review, there is currently no high-quality evidence from randomised controlled trials regarding clinical outcomes for patients with oropharyngeal cancer receiving endoscopic head and neck surgery compared with primary chemoradi...
Source: Cochrane Database of Systematic Reviews - December 10, 2016 Category: Journals (General) Authors: Howard J, Masterson L, Dwivedi RC, Riffat F, Benson R, Jefferies S, Jani P, Tysome JR, Nutting C Tags: Cochrane Database Syst Rev Source Type: research

Glucose transporter GLUT1 expression and clinical outcome in solid tumors: a systematic review and meta-analysis.
Authors: Wang J, Ye C, Chen C, Xiong H, Xie B, Zhou J, Chen Y, Zheng S, Wang L Abstract Glucose transporter 1 (GLUT1), the uniporter protein encoded by the SLC2A1 gene, is a key rate-limiting factor in the transport of glucose in cancer cells, and frequently expressed in a significant proportion of human cancers. Numerous studies have reported paradoxical evidence of the relationship between GLUT1 expression and prognosis in solid human tumors. To address this discrepancy, we conducted a thorough search of Pubmed and Web of Science for studies evaluating the expression of GLUT1 and overall survival (OS) and disease...
Source: Oncotarget - February 13, 2017 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Prophylactic dissection of level V in primary mucosal SCC in the clinically N positive neck: A systematic review
ConclusionMucosal head and neck SCC presenting with nodal metastasis but with level V clinically uninvolved has a low prevalence of occult level V disease. Routine dissection of level V does not appear to be warranted; however, a definitive conclusion is unable to be drawn due to limited data on morbidity and oncological outcomes. Laryngoscope, 2017
Source: The Laryngoscope - April 15, 2017 Category: ENT & OMF Authors: Timothy McLean, Stephen J. Kerr, Charles E. B. Giddings Tags: Head and Neck Source Type: research

Atypical presentations of cutaneous leishmaniasis: a systematic review.
ATYPICAL PRESENTATIONS OF CUTANEOUS LEISHMANIASIS: A SYSTEMATIC REVIEW. Acta Trop. 2017 May 16;: Authors: Meireles CB, Maia LC, Soares GC, Teodoro IPP, do Socorro Vieira Gadelha M, da Silva CGL, de Lima MAP Abstract Cutaneous Leishmaniasis (CL) is endemic in 88 countries, showing relevant prevalences. The aim of this study was to perform a systematic review on atypical lesions of CL around the world, addressing clinico-epidemiological, immunological and therapeutic aspects. A search of the literature was conducted via electronic databases Scopus and PubMed for articles published between 2010 and 2015....
Source: Acta Tropica - May 16, 2017 Category: Infectious Diseases Authors: Meireles CB, Maia LC, Soares GC, Teodoro IPP, do Socorro Vieira Gadelha M, da Silva CGL, de Lima MAP Tags: Acta Trop Source Type: research

HPV-related vulvar diseases and perspectives of p16INK4a immunochemistry: a review of the literature.
CONCLUSIONS: Our findings indicated that p16INK4a or p16INK4a/p53 immunoreactivity, along with histological diagnosis, could be a convenient means to adequately classify VIN and its connection to HPV infection. Therefore, the clear recognition of HPV-associated VIN would lead to an appropriate strategy of treatment and follow-up. PMID: 28574130 [PubMed - as supplied by publisher]
Source: Tumori - June 4, 2017 Category: Cancer & Oncology Tags: Tumori Source Type: research

Chemoradiotherapy versus chemoradiotherapy plus surgery for esophageal cancer.
CONCLUSIONS: Based on the available evidence, the addition of esophagectomy to chemoradiotherapy in locally advanced esophageal squamous cell carcinoma, provides little or no difference on overall survival, and may be associated with higher treatment-related mortality. The addition of esophagectomy probably delays locoregional relapse, however, this end point was not well defined in the included studies. It is undetermined whether these results can be applied to the treatment of adenocarcinomas, tumors involving the distal esophagus and gastro-esophageal junction, and to people with poor response to chemoradiation. PM...
Source: Cochrane Database of Systematic Reviews - August 22, 2017 Category: General Medicine Authors: Vellayappan BA, Soon YY, Ku GY, Leong CN, Lu JJ, Tey JC Tags: Cochrane Database Syst Rev Source Type: research

Differential expression of an ensemble of the key genes involved in cell-cycle regulation in lung cancer.
Abstract Targeted cancer therapy directed at individual targets is often accompanied by the rapid development of drug resistance. The development of a new generation of antitumor drugs involves the search for many targets simultaneously to block or, conversely, restore their activity. In this regard, simultaneous analysis of gene expression in a complex network of interactions, primarily cell cycle control elements, is relevant for the search of specific molecular markers for the differential diagnosis of adenocarcinoma (ADC) and squamous cell lung cancer (SCC), as well as new targets for therapy. In this paper we...
Source: Molekuliarnaia Biologiia - September 1, 2017 Category: Molecular Biology Authors: Krasnov GS, Puzanov GA, Kudryavtseva AV, Dmitriev AA, Beniaminov AD, Kondratieva TT, Senchenko VN Tags: Mol Biol (Mosk) Source Type: research

Palliative chemotherapy and targeted therapies for esophageal and gastroesophageal junction cancer.
CONCLUSIONS: People who receive more chemotherapeutic or targeted therapeutic agents have an increased overall survival compared to people who receive less. These agents, administered as both first-line or second-line treatments, also led to better overall survival than best supportive care. With the exception of ramucirumab, it remains unclear which other individual agents cause the survival benefit. Although treatment-associated toxicities of grade 3 or more occurred more frequently in arms with an additional chemotherapy or targeted therapy agent, there is no evidence that palliative chemotherapy and/or targeted therapy...
Source: Cochrane Database of Systematic Reviews - November 28, 2017 Category: General Medicine Authors: Janmaat VT, Steyerberg EW, van der Gaast A, Mathijssen RH, Bruno MJ, Peppelenbosch MP, Kuipers EJ, Spaander MC Tags: Cochrane Database Syst Rev Source Type: research

MicroRNAs as effective surrogate biomarkers for early diagnosis of oral cancer
ConclusionsA number of studies demonstrated that miRNAs may be developed as an ideal set of biomarkers used for early diagnosis and prognosis of cancers because of the stability in human peripheral blood and body fluids and availability of non-invasive approaches being developed for clinical utility. Clinical relevance: These findings suggest that miRNAs as biomarkers may be useful for diagnosis of OC.
Source: Clinical Oral Investigations - January 3, 2018 Category: Dentistry Source Type: research

Chronic urinary tract infection and bladder carcinoma risk: a meta-analysis of case –control and cohort studies
ConclusionsChronic UTI was significantly and independently associated with an increased BCa risk. However, due to the presence of high  between-study heterogeneity and inconsistent patterns of adjusted confounding effects, more data are needed to clarify the role of chronic UTI in causation of BCa and if established, prompt and effective treatment of UTI may minimize a substantial proportion of BCa risk.
Source: World Journal of Urology - February 5, 2018 Category: Urology & Nephrology Source Type: research

Salvage of recurrence after surgery and adjuvant therapy: A systematic review
Conclusions Patients undergoing salvage surgery for recurrent head and neck squamous cell carcinoma after initial surgery and adjuvant therapy may have a particularly poor prognosis. Future studies are needed to determine functional and quality of life outcomes in this patient population and to identify specific prognostic factors for re-recurrence and survival.
Source: American Journal of Otolaryngology - February 21, 2018 Category: Endocrinology Source Type: research

Genome Wide Association Analyses Identify Pleiotropic Variants Associated with Acute Myeloid Leukemia (AML) and Myelodysplastic Syndrome (MDS) Susceptibility
The first two authors and last two authors contributed equally.Genome-wide association studies (GWAS) have identified risk loci for Acute Lymphoblastic Leukemia (ALL), Chronic Lymphoblastic Leukemia (CLL) and Non-Hodgkin Lymphoma, however an Acute Myeloid Leukemia (AML) GWAS has not been published to date. We performed a GWAS to identify AML and Myelodysplastic Syndrome (MDS) risk loci using a nested case-control study design in the DISCOVeRY-BMT cohorts which includes almost 2000 AML and MDS patients as cases and 2813 unrelated donors as controls.Genotyping was performed using the Illumina Human OmniExpress BeadChip and i...
Source: Blood - November 21, 2018 Category: Hematology Authors: Wang, J., Clay-Gilmour, A. I., Karaesmen, E., Rizvi, A., Zhu, Q., Yan, L., Preus, L., Liu, S., Stram, D., Pooler, L., Cheng, X., Haiman, C., Van Den Berg, D., Webb, A., Brock, G., Griffiths, E. A., Spellman, S. R., Pasquini, M. C., McCarthy, P. L., Allan, Tags: 617. Acute Myeloid Leukemia: Biology, Cytogenetics, and Molecular Markers in Diagnosis and Prognosis: Poster I Source Type: research

Computer-assisted diagnosis techniques (dermoscopy and spectroscopy-based) for diagnosing skin cancer in adults.
CONCLUSIONS: In highly selected patient populations all CAD types demonstrate high sensitivity, and could prove useful as a back-up for specialist diagnosis to assist in minimising the risk of missing melanomas. However, the evidence base is currently too poor to understand whether CAD system outputs translate to different clinical decision-making in practice. Insufficient data are available on the use of CAD in community settings, or for the detection of keratinocyte cancers. The evidence base for individual systems is too limited to draw conclusions on which might be preferred for practice. Prospective comparative studie...
Source: Cochrane Database of Systematic Reviews - December 3, 2018 Category: General Medicine Authors: Ferrante di Ruffano L, Takwoingi Y, Dinnes J, Chuchu N, Bayliss SE, Davenport C, Matin RN, Godfrey K, O'Sullivan C, Gulati A, Chan SA, Durack A, O'Connell S, Gardiner MD, Bamber J, Deeks JJ, Williams HC, Cochrane Skin Cancer Diagnostic Test Accuracy Group Tags: Cochrane Database Syst Rev Source Type: research

Optical coherence tomography for diagnosing skin cancer in adults.
CONCLUSIONS: Insufficient data are available on the use of OCT for the detection of melanoma or cSCC. Initial data suggest conventional OCT may have a role for the diagnosis of BCC in clinically challenging lesions, with our meta-analysis showing a higher sensitivity and higher specificity when compared to visual inspection plus dermoscopy. However, the small number of studies and varying methodological quality means implications to guide practice cannot currently be drawn.Appropriately designed prospective comparative studies are required, given the paucity of data comparing OCT with dermoscopy and other similar diagnosti...
Source: Cochrane Database of Systematic Reviews - December 3, 2018 Category: General Medicine Authors: Ferrante di Ruffano L, Dinnes J, Deeks JJ, Chuchu N, Bayliss SE, Davenport C, Takwoingi Y, Godfrey K, O'Sullivan C, Matin RN, Tehrani H, Williams HC, Cochrane Skin Cancer Diagnostic Test Accuracy Group Tags: Cochrane Database Syst Rev Source Type: research

Exfoliative cytology for diagnosing basal cell carcinoma and other skin cancers in adults.
CONCLUSIONS: The utility of exfoliative cytology for the primary diagnosis of skin cancer is unknown, as all included studies focused on the use of this technique for confirming strongly suspected clinical diagnoses. For the confirmation of BCC in lesions with a high clinical suspicion, there is evidence of high sensitivity and specificity. Since decisions to treat low-risk BCCs are unlikely in practice to require diagnostic confirmation given that clinical suspicion is already high, exfoliative cytology might be most useful for cases of BCC where the treatments being contemplated require a tissue diagnosis (e.g. radiother...
Source: Cochrane Database of Systematic Reviews - December 3, 2018 Category: General Medicine Authors: Ferrante di Ruffano L, Dinnes J, Chuchu N, Bayliss SE, Takwoingi Y, Davenport C, Matin RN, O'Sullivan C, Roskell D, Deeks JJ, Williams HC, Cochrane Skin Cancer Diagnostic Test Accuracy Group Tags: Cochrane Database Syst Rev Source Type: research