Filtered By:
Cancer: Squamous Cell Carcinoma

This page shows you your search results in order of relevance. This is page number 20.

Order by Relevance | Date

Total 783 results found since Jan 2013.

Non-thermal atmospheric pressure plasma induces apoptosis in oral cavity squamous cell carcinoma: Involvement of DNA-damage-triggering sub-G1 arrest via the ATM/p53 pathway.
In this study, we report for the first time that NTP led to apoptotic cell death in oral cavity squamous cell carcinoma (OSCC). Interestingly, NTP induced a sub-G1 arrest in p53 wild-type OSCCs, but not in p53-mutated OSCCs. In addition, NTP increased the expression levels of ATM, p53 (Ser 15, 20 and 46), p21, and cyclin D1. A comet assay, Western blotting and immunocytochemistry of γH2AX suggested that NTP-induced apoptosis and sub-G1 arrest were associated with DNA damage and the ATM/p53 signaling pathway in SCC25 cells. Moreover, ATM knockdown using siRNA attenuated the effect of NTP on cell death, sub-G1 arrest and re...
Source: Archives of Biochemistry and Biophysics - January 29, 2014 Category: Biochemistry Authors: Chang JW, Kang SU, Shin YS, Kim KI, Seo SJ, Yang SS, Lee JS, Moon E, Baek SJ, Lee K, Kim CH Tags: Arch Biochem Biophys Source Type: research

Relation between the expression of mitotic centromere–associated kinesin and the progression of squamous cell carcinoma of the tongue
Objective: Mitotic centromere–associated kinesin (MCAK) is a microtubule depolymerase indispensable for microtubule binding during spindle formation. The purpose of this study was to investigate the association of MCAK expression with squamous cell carcinoma of the oral tongue (SCCOT).Study Design: Immunohistochemistry was used in 47 cases of SCCOT. Determination of proliferation and migratory capabilities was performed with 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and Transwell chamber assay, respectively, on cells from the human tongue squamous cell carcinoma cell line Tca8113 that were ...
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - November 22, 2013 Category: ENT & OMF Authors: Cheng-Qin Wang, Feng-Gang Xiang, Yu-Jun Li, Xiao-Ming Xing, Ning Wang, Jing-Hua Chi, Wen-Juan Yu Tags: Oral and Maxillofacial Pathology Source Type: research

Identification of SRSF1-Regulated Splicing Events
In conclusion, using a novel analytical tool, we have identified new splicing events regulated by the oncogenic splicing factor SRSF1 in lung cancer. Cancer Res; 74(4); 1105–15. ©2013 AACR.
Source: Cancer Research - February 16, 2014 Category: Cancer & Oncology Authors: de Miguel, F. J., Sharma, R. D., Pajares, M. J., Montuenga, L. M., Rubio, A., Pio, R. Tags: Molecular and Cellular Pathobiology Source Type: research

Role of Pax8 in the regulation of MET and RON receptor Tyrosine Kinases in non-small cell lung cancer
Conclusion: PAX8 provides signals for growth and motility of NSCLC cells and is necessary for MET and RON expression. Further investigations are necessary to investigate the therapeutic potential of PA8 in NSCLC.
Source: BMC Cancer - March 14, 2014 Category: Cancer & Oncology Authors: Rajani KantetiEssam El-HashaniImmanuel DhanasinghMaria TretiakovaAliya HusainSherven SharmaJay SharmaEverett VokesRavi Salgia Source Type: research

Heat shock protein 70 is involved in malignant behaviors and chemosensitivities to cisplatin in cervical squamous cell carcinoma cells
ConclusionIt was suggested that HSP70 played functional roles in the progression of uterine cervical SCC, and HSP70 knockdown enhanced chemosensitivities to cisplatin in cervical SCC cells.
Source: Journal of Obstetrics and Gynaecology Research - April 2, 2014 Category: OBGYN Authors: Keiko Yoshidomi, Akihiro Murakami, Kazuyuki Yakabe, Kotaro Sueoka, Shugo Nawata, Norihiro Sugino Tags: Invited Manuscript Source Type: research

Effect of hypoxia on the expression of alphaB-crystallin in head and neck squamous cell carcinoma
Conclusions: We provide the first evidence that hypoxia stimulates upregulation of alphaB-crystallin in HNSCC. This upregulation was not caused by the low oxygen pressure, but more likely by ROS formation. The higher expression of alphaB-crystallin may lead to prolonged survival of these cells under hypoxic conditions.
Source: BMC Cancer - April 11, 2014 Category: Cancer & Oncology Authors: Chantal van de SchootbruggeElisabeth SchultsJohan BussinkPaul SpanReidar GrénmanGer PruijnJohannes KaandersWilbert Boelens Source Type: research

Effect of hypoxia on the expression of ¿B-crystallin in head and neck squamous cell carcinoma
Conclusions: We provide the first evidence that hypoxia stimulates upregulation of αB-crystallin in HNSCC. This upregulation was not caused by the low oxygen pressure, but more likely by ROS formation. The higher expression of αB-crystallin may lead to prolonged survival of these cells under hypoxic conditions.
Source: BMC Cancer - April 11, 2014 Category: Cancer & Oncology Authors: Chantal van de SchootbruggeElisabeth SchultsJohan BussinkPaul SpanReidar GrénmanGer PruijnJohannes KaandersWilbert Boelens Source Type: research

Suppression of TRAP1 expression induces inhibition of cell proliferation and tumor growth in human esophageal cancer cell
ConclusionsThis study shows that TRAP1 was overexpressed in most patients with ESCC, and exerted enhanced antiapoptosis potency. TRAP1 may be regarded as a target in ESCC biotherapy.This article is protected by copyright. All rights reserved.
Source: FEBS Journal - April 1, 2014 Category: Research Authors: Xin Tian, Ping Ma, Cheng‐Guang Sui, Fan‐Dong Meng, Yan Li, Li‐Ye Fu, Tao Jiang, Yang Wang, You‐Hong Jiang Tags: Original Article Source Type: research

In vitro study of normoxic epidermal growth factor (EGF)‐induced HIF‐1α, VEGF and BNIP3 expression in head and neck squamous cell carcinoma cell lines: implications for anti‐EGFR therapy
Conclusions The search for molecular predictors of sensitivity to gefitinib in HNSCC should be extended to the activation status of EGFR‐downstream pathways, pAkt, pMAPK, and HIF‐1α. Head Neck, 2014
Source: Head and Neck - May 2, 2014 Category: ENT & OMF Authors: Pablo Secades, Inés Saenz de Santamaría, Anna Merlo, Carlos Suarez, María‐Dolores Chiara Tags: Original Article Source Type: research

Aldo‐keto Reductase 1C3 (AKR1C3) is overexpressed in skin squamous cell carcinoma (SCC) and affects SCC growth via prostaglandin metabolism
This article is protected by copyright. All rights reserved.
Source: Experimental Dermatology - June 10, 2014 Category: Dermatology Authors: Alon Mantel, Amanda Carpenter‐Mendini, JoAnne VanBuskirk, Alice P. Pentland Tags: Regular Article Source Type: research

Down-regulated γ-catenin expression is associated with tumor aggressiveness in esophageal cancer.
CONCLUSION: γ-catenin is a tumor suppressor in ESCC and may serve as a prognostic marker. Dysregulated expression of γ-catenin may play important roles in ESCC progression. PMID: 24914344 [PubMed - in process]
Source: World Journal of Gastroenterology - May 21, 2014 Category: Gastroenterology Authors: Fang WK, Liao LD, Gu W, Chen B, Wu ZY, Wu JY, Shen J, Xu LY, Li EM Tags: World J Gastroenterol Source Type: research

Role of LPAR3, PKC and EGFR in LPA-induced cell migration in oral squamous carcinoma cells
Conclusion: The results demonstrate LPA-stimulated migration in oral carcinoma cells through LPAR3, mediated further by PKC, which acts either in concert with or independently of EGFR transactivation.
Source: BMC Cancer - June 13, 2014 Category: Cancer & Oncology Authors: Ingvild BrusevoldIngun TveteraasMonica AasrumJohn ØdegårdDagny SandnesThoralf Christoffersen Source Type: research

In vitro study of normoxic epidermal growth factor receptor–induced hypoxia‐inducible factor‐1‐alpha, vascular endothelial growth factor, and BNIP3 expression in head and neck squamous cell carcinoma cell lines: Implications for anti–epidermal growth factor receptor therapy
ConclusionThe search for molecular predictors of sensitivity to gefitinib in HNSCC should be extended to the activation status of EGFR‐downstream pathways, phosphorylated protein kinase B, pMAPK, and HIF‐1α. © 2014 Wiley Periodicals, Inc. Head Neck, 2014
Source: Head and Neck - July 7, 2014 Category: ENT & OMF Authors: Pablo Secades, Inés Saenz Santa‐María, Anna Merlo, Carlos Suarez, María‐Dolores Chiara Tags: Original Article Source Type: research

Aldo‐keto reductase 1C3 is overexpressed in skin squamous cell carcinoma (SCC) and affects SCC growth via prostaglandin metabolism
Abstract Aldo‐keto reductase 1C3 (AKR1C3) is an enzyme involved in metabolizing prostaglandins (PGs) and sex hormones. It metabolizes PGD2 to 9α11β‐PGF2, diverting the spontaneous conversion of PGD2 to the PPARγ agonist, 15‐Deoxy‐Delta‐12, 14‐prostaglandin J2 (15d‐PGJ2). AKR1C3 is overexpressed in various malignancies, suggesting a tumor promoting function. This work investigates AKR1C3 expression in human non‐melanoma skin cancers, revealing overexpression in squamous cell carcinoma (SCC). Effects of AKR1C3 overexpression were then evaluated using three SCC cell lines. AKR1C3 was detected in all SCC cel...
Source: Experimental Dermatology - July 16, 2014 Category: Dermatology Authors: Alon Mantel, Amanda Carpenter‐Mendini, JoAnne VanBuskirk, Alice P. Pentland Tags: Original Article Source Type: research

A novel long non-coding RNA FOXCUT and mRNA FOXC1 pair promote progression and predict poor prognosis in esophageal squamous cell carcinoma.
In conclusion, FOXCUT may be functionally involved in the tumor progression and survival of ESCC patients, at least in part, by modulating FOXC1. FOXCUT and FOXC1 may function as a lncRNA-mRNA gene pair, which may represent a potential prognostic biomarker and therapeutic target for ESCC patients. PMID: 25031703 [PubMed - in process]
Source: International Journal of Clinical and Experimental Pathology - July 19, 2014 Category: Pathology Authors: Pan F, Yao J, Chen Y, Zhou C, Geng P, Mao H, Fang X Tags: Int J Clin Exp Pathol Source Type: research