Effect of hypoxia on the expression of alphaB-crystallin in head and neck squamous cell carcinoma
Conclusions:
We provide the first evidence that hypoxia stimulates upregulation of alphaB-crystallin in HNSCC. This upregulation was not caused by the low oxygen pressure, but more likely by ROS formation. The higher expression of alphaB-crystallin may lead to prolonged survival of these cells under hypoxic conditions.
Source: BMC Cancer - Category: Cancer & Oncology Authors: Chantal van de SchootbruggeElisabeth SchultsJohan BussinkPaul SpanReidar GrénmanGer PruijnJohannes KaandersWilbert Boelens Source Type: research
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