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Total 153 results found since Jan 2013.

Definitive chemoradiotherapy for advanced cervical cancer: should it be different in the elderly?
Conclusions Despite advanced age, more than 60% of pts underwent complete CRT treatment. Thus, age should not be the only factor to guide therapeutic decisions in CC. Carboplatin was better tolerated
Source: European Journal of Obstetrics and Gynecology and Reproductive Biology - June 20, 2015 Category: OBGYN Source Type: research

Transient memory impairment and transient global amnesia induced by photodynamic therapy
This article is protected by copyright. All rights reserved.
Source: British Journal of Dermatology - June 30, 2015 Category: Dermatology Authors: M. Reinholz, M.V. Heppt, F. Hoffmann, N. Lummel, T. Ruzicka, P. Lehmann, C. Berking Tags: Case Report Source Type: research

PodMed: A Medical News Roundup From Johns Hopkins (with audio)
(MedPage Today) -- This week's topics include citrus and melanoma, a new oral medication for obesity, stroke treatment guidelines, and a vaccine for Helicobacter pylori.
Source: MedPage Today Dermatology - July 5, 2015 Category: Dermatology Source Type: news

Sun Safety at Work Canada: a multiple case-study protocol to develop sun safety and heat protection programs and policies for outdoor workers
DiscussionSolar UV and heat are both health and safety hazards. Using an occupational health and safety risk assessment and control framework, Sun Safety at Work Canada will support workplaces to assess their exposure risks, implement control strategies that build on their existing programs, and embed the controls into their existing occupational health and safety system.
Source: Implementation Science - July 10, 2015 Category: Health Management Authors: Desre KramerThomas TenkatePeter StrahlendorfRivka KushnerAudrey GardnerD. Holness Source Type: research

Mortality and comorbidities in patients with multiple sclerosis compared with a population without multiple sclerosis: An observational study using the US department of defense administrative claims database
Conclusions Rates of mortality and several comorbidities are higher in the MS versus non-MS cohort. Early recognition and management of comorbidities may reduce premature mortality and improve quality of life in patients with MS.
Source: Multiple Sclerosis and Related Disorders - August 19, 2015 Category: Neurology Source Type: research

Tildrakizumab (MK‐3222), an anti‐interleukin‐23p19 monoclonal antibody, improves psoriasis in a phase IIb randomized placebo‐controlled trial
ConclusionsTildrakizumab had treatment effects that were superior to placebo, maintained for 52 weeks of treatment, and persisted for 20 weeks after cessation. Tildrakizumab was generally safe and well tolerated. These results suggest that IL‐23p19 is a key target for suppressing psoriasis.
Source: British Journal of Dermatology - October 15, 2015 Category: Dermatology Authors: K. Papp, D. Thaçi, K. Reich, E. Riedl, R.G. Langley, J.G. Krueger, A.B. Gottlieb, H. Nakagawa, E.P. Bowman, A. Mehta, Q. Li, Y. Zhou, R. Shames Tags: Clinical Trials Source Type: research

Neuron-Specific Enolase as a Biomarker: Biochemical and Clinical Aspects.
Authors: Isgrò MA, Bottoni P, Scatena R Abstract Neuron-specific enolase (NSE) is known to be a cell specific isoenzyme of the glycolytic enzyme enolase. In vertebrate organisms three isozymes of enolase, expressed by different genes, are present: enolase α is ubiquitous; enolase β is muscle-specific and enolase γ is neuron-specific. The expression of NSE, which occurs as γγ- and αγ-dimer, is a late event in neural differentiation, thus making it a useful index of neural maturation.NSE is a highly specific marker for neurons and peripheral neuroendocrine cells. As a result of the findings of NSE in specific...
Source: Advances in Experimental Medicine and Biology - November 6, 2015 Category: Research Tags: Adv Exp Med Biol Source Type: research

Simultaneous carotid endarterectomy and free flap surgery for head and neck microvascular reconstruction
Introduction/aims: Microvascular free flaps are the gold standard for reconstruction of head and neck defects. However, suitable recipient vessels are essential. Stenosis of the carotid tree is most commonly due to atherosclerosis, which shares risk factors with head and neck squamous cell carcinoma. Free flaps are often not carried out in these patients due to the risk of failure and complications. Carotid endarterectomy (CEA) offers an evidence based intervention for stroke risk reduction but its use for improving vascularity to free flaps has not been previously reported.
Source: The British Journal of Oral and Maxillofacial Surgery - December 1, 2015 Category: ENT & OMF Authors: N. Opie, N. Pattni, S. Colley, M. Simms, P. Praveen, T. Martin, S. Parmar Tags: P 76 Source Type: research

Dual effects of acetylsalicylic acid on ERK signaling and Mitf transcription lead to inhibition of melanogenesis.
Abstract Acetylsalicylic acid (ASA) is widely used as an analgesic/antipyretic drug. It exhibits a wide range of biological effects, including preventative effects against heart attack and stroke, and the induction of apoptosis in various cancer cells. We previously found that ASA inhibits melanogenesis in B16 melanoma cells. However, the mechanisms of how ASA down-regulates melanin synthesis remain unclear. Here, we investigated the effect of ASA on melanogenic pathways, such as extracellular signal-regulated kinase (ERK) and microphthalmia-associated transcription factor (Mitf) transcription. ASA significantly i...
Source: Molecular and Cellular Biochemistry - December 23, 2015 Category: Biochemistry Authors: Nishio T, Usami M, Awaji M, Shinohara S, Sato K Tags: Mol Cell Biochem Source Type: research

Biomarker value and pitfalls of serum S100B in the follow‐up of high‐risk melanoma patients
ConclusionsSerum S100B is a useful quantitative biomarker in routine follow‐up of high‐risk melanoma patients. While false‐negative results are frequent in patients with low tumor load, false‐positive results are associated with several comorbid diseases and warrant careful reevaluation.
Source: JDDG - January 27, 2016 Category: Dermatology Authors: Christoffer Gebhardt, Ramtin Lichtenberger, Jochen Utikal Tags: Original Article Source Type: research

2016 Moon Shot for Cancer: Focus on Prevention
It is now 2016, and Americans hope for a brighter, healthier new year. Are Americans healthier today than they were last year or the year before? Will there be fewer people diagnosed with cancer? According to the American Cancer Society, it is projected that in 2016 there will be 1,685,210 new cancer cases and 595,690 deaths due to cancer. This is an increase over previous years. While it is true that the death rate for several cancers has decreased (due mostly to better screening and earlier diagnosis), it is also true that several cancers are on the rise, including cancers of the thyroid, liver, pancreas, kidney, small i...
Source: Healthy Living - The Huffington Post - February 1, 2016 Category: Consumer Health News Source Type: news

Periodontal disease and risk of all cancers among male never smokers: an updated analysis of the Health Professionals Follow-up Study
Conclusions Advanced periodontitis was associated with a 2.5-fold increase in smoking-related cancers among never smokers. Periodontitis may impact cancer risk through system immune dysregulation. Further studies need to examine the immune impact of advanced periodontitis on cancer, especially for cancers known to be caused by smoking.
Source: Annals of Oncology - April 20, 2016 Category: Cancer & Oncology Authors: Michaud, D. S., Kelsey, K. T., Papathanasiou, E., Genco, C. A., Giovannucci, E. Tags: epidemiology Source Type: research

Discovery of a Novel Anti-Cancer Agent Targeting Both Topoisomerase I & II as well as Telomerase Activities in Human Lung Adenocarcinoma A549 Cells In Vitro and In Vivo: Cinnamomum verum Component Cuminaldehyde.
Discovery of a Novel Anti-Cancer Agent Targeting Both Topoisomerase I & II as well as Telomerase Activities in Human Lung Adenocarcinoma A549 Cells In Vitro and In Vivo: Cinnamomum verum Component Cuminaldehyde. Curr Cancer Drug Targets. 2016 Apr 26; Authors: Chen TW, Tsai KD, Yang SM, Wong HY, Liu YH, Cherng J, Chou KS, Wang YT, Cuizon J, Cherng JM Abstract Cinnamomum verum is used to make the spice cinnamon and has been used for more than 5000 years by both of the two most ancient forms of medicine in the words: Ayurveda and traditional Chinese herbal medicines for various applications such as a...
Source: Current Cancer Drug Targets - April 25, 2016 Category: Cancer & Oncology Authors: Chen TW, Tsai KD, Yang SM, Wong HY, Liu YH, Cherng J, Chou KS, Wang YT, Cuizon J, Cherng JM Tags: Curr Cancer Drug Targets Source Type: research

Resection of Intraabdominal Tumors With Cavoatrial Extension Using Deep Hypothermic Circulatory Arrest
Conclusions Intraabdominal malignancies with cavoatrial extension can be safely resected. Excellent local tumor control can be anticipated. Long-term surveillance is necessary to detect recurrence.
Source: The Annals of Thoracic Surgery - May 9, 2016 Category: Cardiovascular & Thoracic Surgery Source Type: research

Resection of Intraabdominal Tumors With Cavoatrial Extension Using Deep Hypothermic Circulatory Arrest.
CONCLUSIONS: Intraabdominal malignancies with cavoatrial extension can be safely resected. Excellent local tumor control can be anticipated. Long-term surveillance is necessary to detect recurrence. PMID: 27173070 [PubMed - as supplied by publisher]
Source: The Annals of Thoracic Surgery - May 8, 2016 Category: Cardiovascular & Thoracic Surgery Authors: Lau C, O'Malley P, Gaudino M, Scherr DS, Girardi LN Tags: Ann Thorac Surg Source Type: research