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The Role of Positron Emission Tomography for the Management of Sinonasal Malignancies: A Systematic Review
CONCLUSIONS: In general, and across all types of sinonasal malignancies, PET scan yielded positive results regarding detection and initial staging. It was also considered as the modality of choice for detection of distant metastases, except in the case of sinonasal lymphoma. PET scan's main limit resides in its inability to detect lesions in or close to the metabolic activity of the brain.PMID:37229633 | DOI:10.1177/19458924231177854
Source: American Journal of Rhinology and Allergy - May 25, 2023 Category: ENT & OMF Authors: David El-Adem Nathan Yang David A Gudis Source Type: research

Blocking IL-19 Signaling Ameliorates Allergen-Induced Airway Inflammation
This study was carried out in accordance with the recommendations of the National Institutes of Health standards and guidelines for the care and use of experimental animals. The protocol was approved by the Animal Ethics Committee of National Cheng Kung University (IACUC NO. 107272 and 105077). Author Contributions J-YW and M-SC designed the study. Y-HW and Y-LL performed the experiments. Y-HW and W-YC analyzed the data. Y-HW, W-YC, and M-SC wrote the manuscript. W-YC and J-YW provided critical technical and scientific guidance and discussion. Funding This work was supported by research grant from the Ministry of Scien...
Source: Frontiers in Immunology - April 29, 2019 Category: Allergy & Immunology Source Type: research

A Systematic Review on Predisposition to Lymphoid (B and T cell) Neoplasias in Patients With Primary Immunodeficiencies and Immune Dysregulatory Disorders (Inborn Errors of Immunity)
Conclusions Though this is not a comprehensive summary of malignancies in PIDDs, or even lymphoproliferative disease in this area, this review summarizes the Medline-indexed published reports of B and T lymphomas in patients with PIDDs. This report highlights the diversity of malignant lymphoproliferative disorders in setting of PIDDs, and its associated challenges of diagnosis and treatment. The pathological classification and nomenclature for the lymphoid malignancies with variably reported and postulated underlying mechanisms were inconsistent and inadequate for many of these published reports. A wide range of treatmen...
Source: Frontiers in Immunology - April 15, 2019 Category: Allergy & Immunology Source Type: research

Beyond CAR T Cells: Other Cell-Based Immunotherapeutic Strategies Against Cancer
Conclusions: CAR T cell therapies have demonstrated the clinical benefits of harnessing our body's own defenses to combat tumor cells. Similar research is being conducted on lesser known modifications and gene-modified immune cells, which we highlight in this review. Introduction Chimeric antigen receptors and engineered T cell receptors (based on previously identified high affinity T cell receptors) function by redirecting T cells to a predefined tumor-specific (or tumor-associated) target. Most of these modifications use retroviral or lentiviral vectors to integrate the construct, and most of the receptors ...
Source: Frontiers in Oncology - April 9, 2019 Category: Cancer & Oncology Source Type: research

Temporal patterns of 18F ‐fluorodeoxyglucose positron emission tomography/computed tomography sinonasal uptake after treatment of sinonasal malignancy
ConclusionOur analysis of PET/CT in patients previously treated for sinonasal malignancy suggests that the posttreatment sinonasal skull base is characterized by a prolonged period of hypermetabolism that endures beyond the period previously described for deep tissue sites of the head and neck. These findings prompt a reevaluation of the previously described 10‐ to 12‐week cutoff point for initial posttreatment PET/CT for head and neck squamous cell carcinoma as applied to sinonasal malignancies.
Source: International Forum of Allergy and Rhinology - July 6, 2016 Category: Allergy & Immunology Authors: Joseph S. Schwartz, Steven G. Brooks, Vanessa Stubbs, Ankona Ghosh, Bobby A. Tajudeen, Sammy Khalili, James N. Palmer, John Y.K. Lee, Seyed Ali Nabavizadeh, Kim O. Learned, Nithin D. Adappa Tags: ORIGINAL ARTICLE Source Type: research

Temporal patterns of 18F‐fluorodeoxyglucose positron emission tomography/computed tomography sinonasal uptake after treatment of sinonasal malignancy
ConclusionOur analysis of PET/CT in patients previously treated for sinonasal malignancy suggests that the posttreatment sinonasal skull base is characterized by a prolonged period of hypermetabolism that endures beyond the period previously described for deep tissue sites of the head and neck. These findings prompt a reevaluation of the previously described 10‐ to 12‐week cutoff point for initial posttreatment PET/CT for head and neck squamous cell carcinoma as applied to sinonasal malignancies.
Source: International Forum of Allergy and Rhinology - July 6, 2016 Category: Allergy & Immunology Authors: Joseph S. Schwartz, Steven G. Brooks, Vanessa Stubbs, Ankona Ghosh, Bobby A. Tajudeen, Sammy Khalili, James N. Palmer, John Y.K. Lee, Seyed Ali Nabavizadeh, Kim O. Learned, Nithin D. Adappa Tags: ORIGINAL ARTICLE Source Type: research

Connecting cyto-nano-architectural attributes and epithelial molecular expression in oral submucous fibrosis progression to cancer
Conclusions Molecular changes related to epithelial progressive maturation and cellular proliferation are correlated with concomitant alteration of epithelial surface architecture which helps to predict the malignant potentiality of OSF.
Source: Journal of Clinical Pathology - July 20, 2015 Category: Pathology Authors: Bag, S., Pal, M., Chaudhary, A., Das, R. K., Paul, R. R., Sengupta, S., Chatterjee, J. Tags: Immunology (including allergy), Clinical diagnostic tests Original article Source Type: research

Management of the orbit during endoscopic sinonasal tumor surgery
ConclusionThis represents the largest series to date on endoscopic management of the orbit in benign and malignant sinonasal tumors. A majority of these cases can be managed by a purely endoscopic approach with low complication and recurrence rates, although a subset still require adjunct open approaches for successful tumor extirpation.
Source: International Forum of Allergy and Rhinology - June 11, 2015 Category: Allergy & Immunology Authors: Brandon Christianson, Carlos Perez, Brian Harrow, Pete S. Batra Tags: ORIGINAL ARTICLE Source Type: research

Children’s Health in Latin America: The Influence of Environmental Exposures
Conclusions: To control environmental threats to children’s health in Latin America, WHO, including PAHO, will focus on the most highly prevalent and serious hazards—indoor and outdoor air pollution, water pollution, and toxic chemicals. Strategies for controlling these hazards include developing tracking data on regional trends in children’s environmental health (CEH), building a network of Collaborating Centres, promoting biomedical research in CEH, building regional capacity, supporting development of evidence-based prevention policies, studying the economic costs of chronic diseases in children, and developing pl...
Source: EHP Research - March 2, 2015 Category: Environmental Health Authors: Web Admin Tags: Review March 2015 Source Type: research

The feasibility of (18)F-fluorodeoxyglucose-positron emission tomography uptake as a prognostic factor for paranasal sinus malignancy.
CONCLUSION: In our study, we concluded that subjects with higher tumor FDG uptakes should be considered for a more aggressive disease. PMID: 23562200 [PubMed - in process]
Source: American Journal of Rhinology and Allergy - March 1, 2013 Category: ENT & OMF Authors: Seol JH, Kim J, Lee JD, Lee JG, Yoon JH, Kim CH Tags: Am J Rhinol Allergy Source Type: research