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Total 27 results found since Jan 2013.

Distinct cardiovascular and cancer burdens associated with social position, work environment and unemployment: a cross-sectional and retrospective study in a large population-based French cohort
Conclusions Social position, work environment and unemployment are associated with distinct cardiovascular and cancerous diseases that could add up during lifetime, they should therefore be considered all together in any preventive strategy.
Source: BMJ Open - July 31, 2023 Category: General Medicine Authors: Sanchez Rico, M., Plessz, M., Airagnes, G., Ribet, C., Hoertel, N., Goldberg, M., Zins, M., Meneton, P. Tags: Open access, Epidemiology Source Type: research

Uncontrolled Heart Risk Factors Common in Head, Neck Squamous Cell Cancer
THURSDAY, June 29, 2023 -- The burden of suboptimally controlled cardiovascular (CV) risk factors and incident risk of stroke and myocardial infarction (MI) are considerable in patients with head and neck squamous cell carcinoma (HNSCC), according...
Source: Drugs.com - Pharma News - June 29, 2023 Category: Pharmaceuticals Source Type: news

Risk of Cardiovascular Events Among Patients With Head and Neck Cancer
This cohort study examines cardiovascular risk profiles, incident stroke, myocardial infarction, and mortality in US veterans with head and neck squamous cell carcinoma.
Source: JAMA Otolaryngology - Head and Neck Surgery - June 22, 2023 Category: ENT & OMF Source Type: research

Janssen Data at ASCO GU Support Ambition to Transform Treatment of Prostate and Bladder Cancer Through Precision Medicine and Early Intervention
RARITAN, N.J., February 13, 2023 – The Janssen Pharmaceutical Companies of Johnson & Johnson today announced plans to present more than 20 abstracts featuring seven oncology therapies from its robust portfolio and pipeline at the annual American Society of Clinical Oncology (ASCO) Genitourinary (GU) Cancers Symposium, taking place in San Francisco on February 16-18. Building on more than a decade of leadership in the development of medicines for people diagnosed with GU cancers, Janssen will present data demonstrating its ambition to advance patient-centered treatment through precision medicine, real-world evidence a...
Source: Johnson and Johnson - February 13, 2023 Category: Pharmaceuticals Tags: Latest News Source Type: news

Association between baseline cardiovascular risk and incidence rates of major adverse cardiovascular events and malignancies in patients with psoriatic arthritis and psoriasis receiving tofacitinib
CONCLUSION: In tofacitinib-treated patients with PsA/PsO, increased ASCVD risk and baseline MetS were associated with higher IRs for MACE and malignancies. Our results support assessing CV risk in patients with PsA/PsO and suggest enhanced cancer monitoring in those with increased ASCVD risk.REGISTRATION CLINICALTRIALSGOV: NCT01877668/NCT01882439/NCT01976364/NCT00678210/NCT01710046/NCT01241591/NCT01186744/NCT01276639/NCT01309737/NCT01163253.PLAIN LANGUAGE SUMMARY: People who have psoriatic arthritis or psoriasis may have more heart-related problems and cancer if they have a higher risk of cardiovascular disease: A study in...
Source: Adv Data - February 13, 2023 Category: Epidemiology Authors: Lars E Kristensen Bruce Strober Denis Poddubnyy Ying-Ying Leung Hyejin Jo Kenneth Kwok Ivana Vranic Dona L Fleishaker Lara Fallon Arne Yndestad Dafna D Gladman Source Type: research

The AIM2 Inflammasome: A Novel Biomarker and Target in Cardiovascular Disease
Pharmacol Res. 2022 Nov 1:106533. doi: 10.1016/j.phrs.2022.106533. Online ahead of print.ABSTRACTAbsent in melanoma 2(AIM2) is a cytoplasmic sensor that recognizes the double-strand DNA. AIM2 inflammasome is a protein platform in the cell that initiates innate immune responses by cleaving pro-caspase-1 and converting IL-1β and IL-18 to their mature forms. Additionally, AIM2 inflammasome promotes pyroptosis by converting Gasdermin-D(GSDMD) to GSDMD-N fragments. An increasing number of studies have indicated the important and decisive roles of the AIM2 inflammasome, IL-1β, and pyroptosis in cardiovascular diseases, such as...
Source: Atherosclerosis - November 4, 2022 Category: Cardiology Authors: Luping Du Xuyang Wang Siyuan Chen Xiaogang Guo Source Type: research

Cardiovascular disease and malignant melanoma
In the last decade, systemic therapies such as immune checkpoint inhibitors and BRAF-MEK inhibitors have improved the prognosis of high-risk and advanced melanoma. With improved survival, melanoma survivorship is increasingly important, particularly in patients who have a good prognosis or are diagnosed at a younger age. It is increasingly recognized that cancer and its treatment is associated with increased cardiovascular morbidity and mortality. Indeed, data from observational studies and meta-analyses of randomized controls trials in melanoma show that systemic therapies may be associated with cardiac toxicities, such a...
Source: Melanoma Research - April 29, 2022 Category: Cancer & Oncology Tags: Review article Source Type: research

Janssen to Present the Strength and Promise of its Hematologic Malignancies Portfolio and Pipeline at ASH 2021
RARITAN, N.J., November 4, 2021 – The Janssen Pharmaceutical Companies of Johnson & Johnson announced today that more than 45 company-sponsored abstracts, including 11 oral presentations, plus more than 35 investigator-initiated studies will be featured at the American Society of Hematology (ASH) Annual Meeting and Exposition. ASH is taking place at the Georgia World Congress Center in Atlanta and virtually from December 11-14, 2021.“We are committed to advancing the science and treatment of hematologic malignancies and look forward to presenting the latest research from our robust portfolio and pipeline during ASH...
Source: Johnson and Johnson - November 5, 2021 Category: Pharmaceuticals Tags: Innovation Source Type: news

New Analyses Suggest Favorable Results for STELARA ® (ustekinumab) When Used as a First-Line Therapy for Bio-Naïve Patients with Moderately to Severely Active Crohn’s Disease and Ulcerative Colitis
SPRING HOUSE, PENNSYLVANIA, October 25, 2021 – The Janssen Pharmaceutical Companies of Johnson & Johnson today announced data from two new analyses of STELARA® (ustekinumab) for the treatment of adults with moderately to severely active Crohn’s disease (CD) and ulcerative colitis (UC).1,2 In a modelled analysisa focused on treatment sequencing using data from randomized controlled trials, network meta-analysis and literature, results showed patient time spent in clinical remission or response was highest when STELARA was used as a first-line advanced therapy for bio-naïve patients with moderately to severely acti...
Source: Johnson and Johnson - October 25, 2021 Category: Pharmaceuticals Tags: Innovation Source Type: news

Janssen Announces U.S. FDA Approval of PONVORY ™ (ponesimod), an Oral Treatment for Adults with Relapsing Multiple Sclerosis Proven Superior to Aubagio® (teriflunomide) in Reducing Annual Relapses and Brain Lesions
TITUSVILLE, N.J. – (March 19, 2021) – The Janssen Pharmaceutical Companies of Johnson & Johnson today announced that the U.S. Food and Drug Administration (FDA) approved PONVORY™ (ponesimod), a once-daily oral selective sphingosine-1-phosphate receptor 1 (S1P1) modulator, to treat adults with relapsing forms of multiple sclerosis (MS), to include clinically isolated syndrome, relapsing-remitting disease and active secondary progressive disease.1,2,3 PONVORY™ offers MS patients superior efficacy in reducing annualized relapse rates compared to an established oral therapy and a proven safety profile backed by ove...
Source: Johnson and Johnson - March 19, 2021 Category: Pharmaceuticals Tags: Innovation Source Type: news

Q & A: UArizona Expert Talks Sleep Apnea, ' Coronasomnia ' and Snoozing in Space
Q&A: UArizona Expert Talks Sleep Apnea,'Coronasomnia' and Snoozing in Space UArizona sleep researchers are working to tackle insomnia, sleep apnea and pandemic-induced " coronasomnia. " Mikayla Mace Kelley Today University Communicationsman-5522892_1920.jpgHealthCollege of Medicine - TucsonCollege of ScienceCOVID-19 Media contact(s)Mikayla Mace Kelley University Communicationsmikaylamace@arizona.edu520-621-1878 Researcher contact(s)Sairam Parthasarathy College of Medicine – Tucsonspartha1@arizona.edu520-626-8309Sleep apnea and insomnia have been on the rise for decades, but the COVID-19 pandemic ha...
Source: The University of Arizona: Health - March 15, 2021 Category: Universities & Medical Training Authors: mikaylamace Source Type: research

Sex Difference of Radiation Response in Occupational and Accidental Exposure
Conclusion and Outlook This review summarizes the data from major human studies on the health risks of radiation exposure and shows that sex can potentially influence the prolonged response to radiation exposure (Figure 1 and Tables 1, 2). These data suggest that long-term radiosensitivity in females is higher than that in males who receive a comparable dose of radiation. Our analysis of the literature agrees with the conclusions of the recent report on the Biological effects of ionizing radiation (BEIR VII) published in 2006 by the National Academy of Sciences (NAS), United States (National Research Council, 2006). The B...
Source: Frontiers in Genetics - May 2, 2019 Category: Genetics & Stem Cells Source Type: research

Black pleural effusion as the presenting feature of lung cancer.
Conclusion: In the present case, the black stain most likely results from intrapleural haemolysis following haemorrhage. Pleural fluid bilirubin may be useful in evaluating pleural effusion, especially if black.
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Fernandes, V., Alfaro, T. M., Cruz, C., Cordeiro, C. R. Tags: Clinical Problems Source Type: research

Urine Arsenic and Arsenic Metabolites in U.S. Adults and Biomarkers of Inflammation, Oxidative Stress, and Endothelial Dysfunction: A Cross-Sectional Study
Conclusion: In a cross-sectional study of U.S. adults, we observed some positive associations of uAs and toenail As concentrations with biomarkers potentially relevant to CVD pathogenesis and inflammation, and evidence of a higher capacity to metabolize inorganic As was negatively associated with a marker of oxidative stress. https://doi.org/10.1289/EHP2062 Received: 14 April 2017 Revised: 13 November 2017 Accepted: 15 November 2017 Published: 15 December 2017 Address correspondence to S.F. Farzan, 2001 N. Soto St., Los Angeles, CA, 90032. Telephone: (323)-442-5101; Email: sffarzan@usc.edu Supplemental Material is ava...
Source: EHP Research - December 16, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research