Filtered By:
Cancer: Ovarian Cancer

This page shows you your search results in order of relevance. This is page number 11.

Order by Relevance | Date

Total 759 results found since Jan 2013.

TXNDC17 promotes paclitaxel resistance via inducing autophagy in ovarian cancer.
Abstract Paclitaxel is recommended as a first-line chemotherapeutic agent against ovarian cancer, but drug resistance becomes a major limitation of its success clinically. The key molecule or mechanism associated with paclitaxel resistance in ovarian cancer still remains unclear. Here, we showed that TXNDC17 screened from 356 differentially expressed proteins by LC-MS/MS label-free quantitative proteomics was more highly expressed in paclitaxel-resistant ovarian cancer cells and tissues, and the high expression of TXNDC17 was associated with poorer prognostic factors and exhibited shortened survival in 157 ovaria...
Source: Autophagy - January 21, 2015 Category: Cytology Authors: Zhang SF, Wang XY, Fu ZQ, Peng QH, Zhang JY, Ye F, Fu YF, Zhou CY, Lu WG, Cheng XD, Xie X Tags: Autophagy Source Type: research

Inhibition of microtubule-associated protein 1 light chain 3B via small-interfering RNA or 3-methyladenine impairs hypoxia-induced HO8910PM and HO8910 epithelial ovarian cancer cell migration and invasion and is associated with RhoA and alterations of the actin cytoskeleton.
Authors: Tang Z, Zhang N, Di W, Li W Abstract Expression of microtubule‑associated protein 1 light chain 3 (LC3) is correlated with poor prognosis in many human cancers. Hypoxia induces LC3 expression and is an essential characteristic of epithelial ovarian cancer (EOC). The aim of the present study was to elucidate the mechanism by which LC3 facilitates EOC cell migration and invasion under conditions of hypoxia. The effects of LC3B inhibition under hypoxic conditions on migration, invasion, and adhesion in HO8910PM and HO8910 EOC cell lines were investigated. LC3B inhibition was achieved by small‑interfering...
Source: Oncology Reports - January 27, 2015 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Expression of BAF57 in ovarian cancer cells and drug sensitivity
In this study, we investigated BAF57 expression in ovarian cancer cell lines and their sensitivities to cisplatin, doxorubicin, paclitaxel, and 5‐fluorouracil. BAF57 expression was strongly correlated with sensitivities to cisplatin, doxorubicin, and 5‐fluorouracil in 10 ovarian cancer cell lines. Paclitaxel sensitivity was also correlated with BAF57 expression, but without significance. In A2780 ovarian cancer cells, knockdown of BAF57 using specific siRNA increased cell cycle arrest at G1 phase and the sensitivities to these anticancer agents. cDNA microarray analysis of A2780 cells transfected with BAF57 siRNA showe...
Source: Cancer Science - February 25, 2015 Category: Cancer & Oncology Authors: Takahiro Yamaguchi, Tomoko Kurita, Kazuto Nishio, Junichi Tsukada, Toru Hachisuga, Yasuo Morimoto, Yoshiko Iwai, Hiroto Izumi Tags: Original Article Source Type: research

Analysis of UHRF1 expression in human ovarian cancer tissues and its regulation in cancer cell growth
In this study, we evaluated the expression level of UHRF1 in ovarian cancer. UHRF1 levels in paired ovarian cancer tissues and adjacent normal tissues from 80 ovarian cancer patients were detected using relative quantitatively PCR and Western blot. Small interfering RNA (siRNA) was introduced in two human ovarian cancer cell lines (SKOV-3 and OVCAR-3) to downregulate the expression of UHRF1. The proliferation of siRNA-treated cells was examined using cell counting kit-8 (CCK-8) assay. The growth of these cells showed a remarkable decrease. Moreover, flow cytometric and Hoechst 33342 assays were used to detect the apoptosis...
Source: Tumor Biology - June 13, 2015 Category: Cancer & Oncology Source Type: research

Berberine Sensitizes Human Ovarian Cancer Cells to Cisplatin Through miR-93/PTEN/Akt Signaling Pathway
Conclusion: The results suggested that berberine modulated the sensitivity of cisplatin through miR-93/PTEN/AKT signaling pathway in the ovarian cancer cells.Cell Physiol Biochem 2015;36:956-965
Source: Cellular Physiology and Biochemistry - June 16, 2015 Category: Cytology Source Type: research

Beclin-1 expression is retained in high-grade serous ovarian cancer yet is not essential for autophagy induction in vitro
Conclusions: Taken together, these data demonstrate that despite its sustained expression, Beclin-1 is dispensable for autophagy induction in ovarian tumor cells in vitro, yet may be retained to promote cell viability by a mechanism independent of autophagy or apoptosis regulation. Overall, this work makes novel observations about tumor expression of Beclin-1 and challenges the accepted understanding of its role in regulating autophagy in ovarian cancer.
Source: Journal of Ovarian Research - August 4, 2015 Category: Cancer & Oncology Authors: Rohann CorreaYudith ValdesTrevor ShepherdGabriel DiMattia Source Type: research

Abstract 294: A novel cancer therapeutic strategy: inducing cytotoxic functions in tumor-associated macrophages
Macrophages are recognized as an important component of the tumor microenvironment. Previous studies have shown that they promote tumor growth and participate in the initiation and progression of metastatic spread. Methods are being developed to eliminate macrophages from the tumor, thereby inhibiting their negative effects. However, we believe that the best approach would be to transform the tumor-helping macrophages into tumor-killing macrophages that would both eliminate tumor cells directly and re-invigorate other immune cells around them to better fight the tumor. Our data indicates that we have found a way to induce ...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Barham, W., Tikhomirov, O., Ortega, R., Saskowski, J., Thompson, C. S., Wilson, A., Blackwell, T., Mirafzali, Z., Khabele, D., Giorgio, T., Yull, F. E. Tags: Immunology Source Type: research

Abstract 313: Examining the role of ABCA1 cholesterol transporter in ovarian cancer spheroids
Epithelial ovarian cancer (EOC) is a devastating disease which accounts for a large proportion of gynaecological cancer-related deaths. Poor survival is largely due to late diagnosis of the disease which typically presents with peritoneal dissemination. In order to achieve reduced tumor burden and improved survival, it is imperative to identify new prognostic markers and potential therapeutic targets. Recent work by our group identified high ATP- Binding Cassette A1 (ABCA1) transporter expression as being associated with poor outcome in EOC. ABCA1 has been widely studied as a cholesterol transporter, however there is littl...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Williams, R., Russell, A., Bongers, A., Sagnella, S., Fife, C., Jessup, W., DeFazio, A., Chenevix-Trench, G., Haber, M., Norris, M., Henderson, M. Tags: Tumor Biology Source Type: research

Abstract 1434: MDM2 promotes tumor cell migration through the induction of epithelial to mesenchymal transition
Conclusion: In summary, this study explored the molecular mechanisms underlying the role of MDM2 in cancer progression. MDM2 expression has been demonstrated to be closely correlated to human ovarian adenocarcinoma clinical staging, indicating the possible utilization of MDM2 in prognosis. Further study clarified MDM2 promoted tumor cell migration through the induction of EMT, which provides new theoretical evidences for the roles that MDM2 plays in tumor metastasis. Our study implicates that MDM2 may be a potential target for inhibiting metastasis and contributes to the translational research of MDM2 inhibitors as anti-me...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Zheng, L., Wu, Y., Zhou, T., Zhu, H., He, Q., Yang, B. Tags: Tumor Biology Source Type: research

Abstract 3368: Sustained adrenergic signaling activates pro-inflammatory prostaglandin network in ovarian carcinoma
Conclusion Increased adrenergic stimulation results in a pro-inflammatory milieu mediated by prostaglandins that drives tumor progression and metastasis in ovarian cancer.Citation Format: Archana S. Nagaraja, Piotr Dorniak, Nouara Sadaoui, Guillermo Armaiz-Pena, Behrouz Zand, Sherry Y. Wu, Julie K. Allen, Rajesha Rupaimoole, Cristian Rodriguez-Aguayo, Sunila Pradeep, Lin Tan, Rebecca A. Previs, Jean M. Hansen, Peiying Yang, Garbiel Lopez-Berestein, Susan K. Lutgendorf, Steve Cole, Anil K. Sood. Sustained adrenergic signaling activates pro-inflammatory prostaglandin network in ovarian carcinoma. [abstract]. In: Proceedings ...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Nagaraja, A. S., Dorniak, P., Sadaoui, N., Armaiz-Pena, G., Zand, B., Wu, S. Y., Allen, J. K., Rupaimoole, R., Rodriguez-Aguayo, C., Pradeep, S., Tan, L., Previs, R. A., Hansen, J. M., Yang, P., Lopez-Berestein, G., Lutgendorf, S. K., Cole, S., Sood, A. K Tags: Tumor Biology Source Type: research

Abstract 4240: TORC inhibition enriches for a cancer stem cell-like population with FGFR-dependent Notch1 activation
Conclusions. These data suggest that treatment of TNBC harboring PI3K pathway aberrations with TORC1/2 inhibitors results in decreased tumor growth but may spare a drug-resistant CSC population with FGFR-Notch signaling. Thus, combination of Notch and TORC1/2 inhibitors in addition to chemotherapy may effectively decrease primary tumor growth and prevent recurrences in TNBC patients.Citation Format: Neil E. Bhola, Valerie M. Jansen, Carlos L. Arteaga. TORC inhibition enriches for a cancer stem cell-like population with FGFR-dependent Notch1 activation. [abstract]. In: Proceedings of the 106th Annual Meeting of the American...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Bhola, N. E., Jansen, V. M., Arteaga, C. L. Tags: Tumor Biology Source Type: research

Abstract 4610: Functional characterization of a multicancer risk locus on chr5p15.33 reveals regulation of TERT by ZNF148
Genome wide association studies (GWAS) have mapped multiple independent cancer risk loci (n = 6) to a small region on chr5p15.33 for at least ten distinct cancers, including bladder, breast, glioma, lung, melanoma, non-melanoma skin, ovarian, pancreas, prostate, and testicular germ cell cancer. This region harbors two plausible target genes, TERT which encodes the catalytic subunit of telomerase reverse transcriptase which maintains chromosome ends by adding telomeres repeats, and CLPTM1L which encodes the cleft lip and palate transmembrane protein 1-like protein which promotes cancer cell growth, protect cells from apopto...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Brown, K. M., Fang, J., Jia, J., Wang, Z., Makowski, M., Zhang, T., Hoskins, J., Choi, J., Han, Y., Zhang, M., Xu, M., Kanetsky, P., Thorkell, A., Petersen, G. M., Nathanson, K. L., Amos, C. I., Landi, M. T., Chanock, S. J., Vermeulen, M., Amundadottir, L Tags: Epidemiology Source Type: research

Abstract 4942: Activation of Phosphatase toward the Retinoblastoma protein in breast and colorectal cancer cell spheroids
Excessive phosphorylation of the Retinoblastoma protein is found in most cancer tumor types. Several cyclin dependent kinase (cdk) inhibitors are in development or in clinical trials at the present time. Our previous studies have focused on the regulation of Rb phosphorylation by the phosphatase, PP1. Specificity toward substrates is imparted onto PP1 by many different interacting proteins. In proliferating cells, PP1 is associated with a regulatory protein called PNUTS (Phosphatase Nuclear Targeting Subunit). Our previous experiments have shown that PNUTS inhibits PP1 activity toward specific Rb phosphorylation sites. Fur...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Egger, J., Antonucci, L., Lane, M., Krucher, N. A. Tags: Molecular and Cellular Biology Source Type: research

Abstract 5466: Integrative TCGA analyses identify Basonuclin1 (BNC1) as a key mediator for platinum resistance
Conclusion. Collectively, BNC1 represents an important target for enhancing platinum-sensitivity in ovarian and lung cancer. Targeting BNC1 in platinum-resistant malignancies may improve patient survival.Note: This abstract was not presented at the meeting.Citation Format: Sherry Y. Wu, Justyna Filant, Michael McGuire, Rajesha Rupaimoole, Sunila Pradeep, Anna Unruh, Herbrich Shelley, Cristina Ivan, Ruder Dennis, Cristian Rodriguez-Aguayo, Vasudha Sehgal, Takahito Miyake, Archana Nagaraja, Kshipra Gharpure, Guillermo Armaiz, Rebecca Previs, Gabriel Lopez-Berestein, Prahlad Ram, Keith Baggerly, Anil Sood. Integrative TCGA an...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Wu, S. Y., Filant, J., McGuire, M., Rupaimoole, R., Pradeep, S., Unruh, A., Shelley, H., Ivan, C., Dennis, R., Rodriguez-Aguayo, C., Sehgal, V., Miyake, T., Nagaraja, A., Gharpure, K., Armaiz, G., Previs, R., Lopez-Berestein, G., Ram, P., Baggerly, K., So Tags: Experimental and Molecular Therapeutics Source Type: research

DKK1 is a potential novel mediator of cisplatin-refractoriness in non-small cell lung cancer cell lines
Conclusions: We identified DKK1 as a possible marker of a cisplatin-refractory phenotype and as a potential novel therapeutic target to improve platinum response of NSCLC cells.
Source: BMC Cancer - September 9, 2015 Category: Cancer & Oncology Authors: Hogir SalimDali ZongPetra HåågMetka NovakBirgitta MörkRolf LewensohnLovisa LundholmKristina Viktorsson Source Type: research