Abstract 1434: MDM2 promotes tumor cell migration through the induction of epithelial to mesenchymal transition

Conclusion: In summary, this study explored the molecular mechanisms underlying the role of MDM2 in cancer progression. MDM2 expression has been demonstrated to be closely correlated to human ovarian adenocarcinoma clinical staging, indicating the possible utilization of MDM2 in prognosis. Further study clarified MDM2 promoted tumor cell migration through the induction of EMT, which provides new theoretical evidences for the roles that MDM2 plays in tumor metastasis. Our study implicates that MDM2 may be a potential target for inhibiting metastasis and contributes to the translational research of MDM2 inhibitors as anti-metastatic agents.Citation Format: Lin Zheng, Yeping Wu, Tianyi Zhou, Hong Zhu, Qiaojun He, Bo Yang. MDM2 promotes tumor cell migration through the induction of epithelial to mesenchymal transition. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 1434. doi:10.1158/1538-7445.AM2015-1434
Source: Cancer Research - Category: Cancer & Oncology Authors: Tags: Tumor Biology Source Type: research