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Forget About Your New Year's Resolutions. Just Put Your Vices To Good Use
It’s your vice. Your Achilles' heel. Your thing. But it’s a thing you can’t -- you won’t -- give up, even if resolution season is here. Hey, we’re not here to judge.
In fact, we have some ways to make you feel pretty good while you might be feeling a tiny bit bad. Here are ways to turn your vices into something that's productive and helps support important causes.
If You’re Always Jonesing For A Cup Of Joe…
Sniff Out Some Beans That Support Needy Communities
You probably don’t stand a chance against the snooze button without a cup of coffee.
So if you must indulge (and yeah, we know -- it's a mus...
Source: Healthy Living - The Huffington Post - January 2, 2015 Category: Consumer Health News Source Type: news
Infertility etiologies are genetically and clinically linked with other diseases in single meta-diseases
The present review aims to ascertain whether different infertility etiologies share particular genes and/or molecular pathways with other pathologies and are associated with distinct and particular risks of later-life morbidity and mortality. In order to reach this aim, we use two different sources of information: (1) a public web server named DiseaseConnect (http://disease-connect.org) focused on the analysis of common genes and molecular mechanisms shared by diseases by integrating comprehensive omics and literature data; and (2) a literature search directed to find clinical comorbid relationships of infertility etiologi...
Source: Reproductive Biology and Endocrinology - April 15, 2015 Category: Endocrinology Authors: Juan TarínMiguel García-PérezToshio HamataniAntonio Cano Source Type: research
TNF-alpha inhibitors for ankylosing spondylitis.
CONCLUSIONS: There is moderate to high quality evidence that anti-TNF agents improve clinical symptoms in the treatment of ankylosing spondylitis. More participants withdrew due to adverse events when on an anti-TNF agent but we did not find evidence of an increase in serious adverse events, though event rates were low and trials had a short duration. The short-term toxicity profile appears acceptable. Based on indirect comparison methodology, we are uncertain whether there are differences between anti-TNF agents in terms of the key benefit or harm outcomes.
PMID: 25887212 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - April 18, 2015 Category: Journals (General) Authors: Maxwell LJ, Zochling J, Boonen A, Singh JA, Veras MM, Tanjong Ghogomu E, Benkhalti Jandu M, Tugwell P, Wells GA Tags: Cochrane Database Syst Rev Source Type: research
The role of endoscopy in the management of premalignant and malignant conditions of the stomach
This is one of a series of statements discussing the use of GI endoscopy in common clinical situations. The Standards of Practice Committee of the American Society for Gastrointestinal Endoscopy (ASGE) prepared this text. In preparing this guideline, a search of the medical literature was performed by using PubMed from January 1980 through March 2014 by using the keyword(s) “gastric tumor,” “gastric cancer,” “gastric lymphoma,” “gastric and adenocarcinoma,” “gastrointestinal stromal tumor,” “gastrointestinal endoscopy,” “endoscopy,” “endoscopic procedures,” and “procedures.” The search w...
Source: Gastrointestinal Endoscopy - April 30, 2015 Category: Gastroenterology Authors: ASGE Standards of Practice Committee, John A. Evans, Vinay Chandrasekhara, Krishnavel V. Chathadi, G. Anton Decker, Dayna S. Early, Deborah A. Fisher, Kimberly Foley, Joo Ha Hwang, Terry L. Jue, Jenifer R. Lightdale, Shabana F. Pasha, Ravi Sharaf, Amandee Tags: Guideline Source Type: research
Endometriosis: a high-risk population for major chronic diseases?
CONCLUSIONS
Increasing evidence suggests that endometriosis patients are at higher risk of several chronic diseases. Although the underlying mechanisms are not yet understood, the available data to date suggest that endometriosis is not harmless with respects to women's long-term health. If these relationships are confirmed, these findings may have important implications in screening practices and in the management and care of endometriosis patients.
Source: Human Reproduction Update - June 11, 2015 Category: OBGYN Authors: Kvaskoff, M., Mu, F., Terry, K. L., Harris, H. R., Poole, E. M., Farland, L., Missmer, S. A. Tags: Reviews Source Type: research
Topical tacrolimus for atopic dermatitis.
CONCLUSIONS: Tacrolimus 0.1% was better than low-potency corticosteroids pimecrolimus 1% and tacrolimus 0.03%. Results were equivocal when comparing both dose formulations to moderate-to-potent corticosteroids. Tacrolimus 0.03% was superior to mild corticosteroids and pimecrolimus. Both tacrolimus formulations seemed to be safe, and no evidence was found to support the possible increased risk of malignancies or skin atrophy with their use. The reliability and strength of the evidence was limited by the lack of data; thus, findings of this review should be interpreted with caution. We did not evaluate costs.
PMID: 2613...
Source: Cochrane Database of Systematic Reviews - July 1, 2015 Category: Journals (General) Authors: Cury Martins J, Martins C, Aoki V, Gois AF, Ishii HA, da Silva EM Tags: Cochrane Database Syst Rev Source Type: research
Incidence of malignancy in adult patients with rheumatoid arthritis: a meta-analysis
Conclusions:
The additional data evaluated here are consistent with previously reported data. Patients with RA are at an increased risk of lung and lymphoma malignancies compared with the general population. Quantifying differences in malignancy rates between non-biologic and biologic DMARD-treated patients with RA may further highlight which malignancies may be related to treatment rather than to the underlying disease.
Source: Arthritis Research and Therapy - August 15, 2015 Category: Rheumatology Authors: Teresa SimonAdam ThompsonKunal GandhiMarc HochbergSamy Suissa Source Type: research
An update of laboratory diagnosis of Helicobacter pylori in the Kingdom of Saudi Arabia
Helicobacter pylori is a micro-aerophilic, slow-growing, Gram-negative spiral bacterium that colonizes the mucous lining of the human stomach. Infection with this bacterium has been identified as a cause of gastritis, peptic ulcer disease, and gastric mucosa-associated lymphoid tissue lymphoma. Globally, the prevalence of H. pylori-related infection is high compared to any other infectious diseases, and the rate of prevalence much higher in developing countries than in developed nations. This review article aims to describe the trend of H. pylori-related works in the Kingdom of Saudi Arabia (KSA) and the use of various lab...
Source: The Journal of Infection in Developing Countries - August 29, 2015 Category: Infectious Diseases Source Type: research
Human Herpesvirus Type-8-associated Large B Cell Lymphoma (HHV-8-LBL). A Non- Serous Extra-Cavitary Variant of Primary Effusion Lymphoma in an HIV-Infected Man: A Case Report and Review of the Literature
Conclusions Our patient’s high CD4+ cell count, lack of pre-existing AIDS diagnosis and excellent response to chemotherapy highlights that HHV-8-LBL may have a distinct clinical picture and possibly a better response to chemotherapy than classic PEL. HHV-8-LBL should be included in the differential diagnosis of HIV patients with solid lesions. It is essential that patients’ CDC HIV clinical status and HIV viral load at time of diagnosis of PEL and HHV-8-LBL be reported and that clinical results include longer-term follow-up. Only then can a more complete clinical picture of this little appreciated and understood PEL va...
Source: Clinical Lymphoma Myeloma and Leukemia - April 1, 2016 Category: Cancer & Oncology Source Type: research
A child with mastocytosis and lymphomatoid papulosis
Key Clinical Message
A change in clinical behavior of a disease should prompt search for differential diagnoses. Here, the appearance of ulcerated skin nodules in a preexisting cutaneous mastocytosis revealed a concurrent lymphomatoid papulosis – a CD30+ lymphoproliferative skin disease with histological features of a malignant lymphoma, but with a benign self‐healing course.
A change in clinical behavior of a disease should prompt search for differential diagnoses. Here, the appearance of ulcerated skin nodules in a preexisting cutaneous mastocytosis revealed a concurrent lymphomatoid papulosis – a CD30+ lymphoprol...
Source: Clinical Case Reports - March 31, 2016 Category: Journals (General) Authors: Henriette Juel Lange, Lone Agertoft, Michael Boe Møller, Ole Clemmensen, Thomas Kristensen, Hanne Vestergaard, Charlotte G. Mørtz, Carsten Bindslev‐Jensen, Sigurd Broesby‐Olsen, Tags: Case Report Source Type: research
Human Herpesvirus Type 8-associated Large B-cell Lymphoma: A Nonserous Extracavitary Variant of Primary Effusion Lymphoma in an HIV-infected Man: A Case Report and Review of the Literature
Conclusion Our patient’s high CD4+ cell count, the lack of a pre-existing AIDS diagnosis, and the excellent response to chemotherapy highlights that HHV-8-LBL might have distinct clinical features and possibly a better response to chemotherapy than classic PEL. HHV-8-LBL should be included in the differential diagnosis of HIV patients with solid lesions. It is essential that patients’ Centers for Disease Control and Prevention HIV clinical status and HIV viral load at the diagnosis of PEL and HHV-8-LBL be reported and that the reported clinical results include longer term follow-up data. Only then will a more complete ...
Source: Clinical Lymphoma Myeloma and Leukemia - May 25, 2016 Category: Cancer & Oncology Source Type: research
Utility of FDG PET/CT in identifying the underlying cause of FUO in an inpatient population, a 10-year experience
Conclusions FDG PET/CT imaging has high diagnostic accuracy (ROC AUC = 0.90, 95% CI [0.85, 0.96]) in the evaluation of fever of unknown origin in this complex inpatient population.
Source: Journal of Nuclear Medicine - May 23, 2016 Category: Nuclear Medicine Authors: Crandall, J., Gajwani, P., Wahl, R. Tags: Infectious Disease/Hematology Source Type: research
Occult neoplasm evaluated with 18F -FDG PET/CT in patients with unprovoked thromboembolic venous disease.
Conclusions The prevalence of occult cancer in patients with UVT was 10.14%. This result is higher than a study recently publish with CT. We suggest the use of 18F -FDG PET/CT as a valuable and better tool than CT alone for the search of occult malignancy in patients with unprovoked TVD RESEARCH SUPPORT: Screening for Occult Cancer in Unprovoked Venous Thromboembolism Marc Carrier, M.D., Alejandro Lazo-Langner, M.D., Sudeep Shivakumar, M.D., Vicky Tagalakis, M.D., Ryan Zarychanski, M.D., Susan Solymoss, M.D., Nathalie Routhier, M.D., James Douketis, M.D., Kim Danovitch, C.C.R.P., Agnes Y. Lee, M.D., Gregoire Le Gal, M.D., ...
Source: Journal of Nuclear Medicine - May 23, 2016 Category: Nuclear Medicine Authors: Loya Teruel, E., Garcia Ortiz, J. R. Tags: MTA I: Educational Exhibits Posters Source Type: research
EGFR and EML4-ALK updated therapies in non-small cell lung cancer.
CONCLUSIONS: Currently, EGFR TKIs (e.g.: erlotinib, gefitinib, olmesertinib) and ALK inhibitors (crizotinib, ceritinib, alectinib) provided a new face for advanced NSCLC outcomes. To understand the disease molecular profile is mandatory to define the best approach for each patient.
PMID: 27491402 [PubMed - as supplied by publisher]
Source: Recent Patents on Anti-Cancer Drug Discovery - August 8, 2016 Category: Cancer & Oncology Tags: Recent Pat Anticancer Drug Discov Source Type: research
