Human Herpesvirus Type-8-associated Large B Cell Lymphoma (HHV-8-LBL). A Non- Serous Extra-Cavitary Variant of Primary Effusion Lymphoma in an HIV-Infected Man: A Case Report and Review of the Literature

Conclusions Our patient’s high CD4+ cell count, lack of pre-existing AIDS diagnosis and excellent response to chemotherapy highlights that HHV-8-LBL may have a distinct clinical picture and possibly a better response to chemotherapy than classic PEL. HHV-8-LBL should be included in the differential diagnosis of HIV patients with solid lesions. It is essential that patients’ CDC HIV clinical status and HIV viral load at time of diagnosis of PEL and HHV-8-LBL be reported and that clinical results include longer-term follow-up. Only then can a more complete clinical picture of this little appreciated and understood PEL variant be defined. Teaser Human Herpes Virus type-8 associated large B cell lymphoma is a variant of primary effusion lymphoma (PEL) that is both solid and extra-cavitary. It has immunoblastic and/or anaplastic morphologic features, a distinct immune-histochemical staining pattern, and may have a different clinical presentation from classic HIV-associated PEL.
Source: Clinical Lymphoma Myeloma and Leukemia - Category: Cancer & Oncology Source Type: research