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Nutrition: Calcium

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Total 207 results found since Jan 2013.

Deubiquitinase USP19 modulates apoptotic calcium release and endoplasmic reticulum stress by deubiquitinating BAG6 in triple negative breast cancer
CONCLUSIONS: Our study reveals that USP19 elevates the intracellular Ca2+ concentration to alter ER stress via regulation of BAG6 and BCL2 stability and may be a viable therapeutic target for TNBC therapy.PMID:37700495 | DOI:10.1002/ctm2.1398
Source: Clinical Breast Cancer - September 13, 2023 Category: Cancer & Oncology Authors: Xiaoqiang Zhang Xuyu Chen Fangze Qian Yanhui Zhu Gao He Junzhe Yang Xian Wu Hongfei Zhang Xiafei Yu Xiaoan Liu Source Type: research

Malignant hypercalcemia revealing a diffuse large B ‐cell lymphoma in a patient with a previous diagnosis of chronic myelomonocytic leukemia: An uncommon hematological coexistence
Key Clinical MessageA 76-year-old patient previously admitted to the cardiology department for replacement of a right ventricular lead on a double-chamber pacemaker was admitted to the internal medicine department 15  days after for bronchopneumopathy. His past medical history was relevant for Type 2 diabetes mellitus, heart failure due to dilated hypokinetic heart disease, transcatheter aortic valve implantation (TAVI), and chronic myelomonocytic leukemia (CMML-0) diagnosed in 2021. Twenty-four hours after ad mission, the patient's general condition deteriorated abruptly, with the onset of drowsiness and psychomotor ret...
Source: Clinical Case Reports - September 4, 2023 Category: General Medicine Authors: Alpha Oumar Diallo, Amelie Marcou, J érémie Lespinasse, Zaida Cordoba‐Sosa, Emmanuel Andrès, Léa Docquier, Noel Lorenzo‐Villalba Tags: CASE REPORT Source Type: research

Plaque Rupture in a Hodgkin Lymphoma Survivor without Cardiovascular Risk Factors 20 Years after Thoracic Radiotherapy: A Case Report
DISCUSSION: In HL survivors treated with thoracic radiotherapy, a calcium score of zero may not give the same warranty period for cardiac event-free survival compared to the general population. Coronary computed tomography angiography can be a proper diagnostic tool to detect CAD at an early stage after mediastinal irradiation, as performing calcium scoring may not be sufficient in this population to detect non-calcified plaques, which may show rapid progression and lead to acute coronary syndrome. Also, intensive lipid-lowering therapy should be considered in the presence of atherosclerosis in this patient population.PMID...
Source: Atherosclerosis - August 25, 2023 Category: Cardiology Authors: Elissa A S Polomski Michiel A de Graaf J Wouter Jukema M Louisa Antoni Source Type: research

CD31 promotes diffuse large B-cell lymphoma metastasis by upregulating OPN through the AKT pathway and inhibiting CD8+ T cells through the mTOR pathway
CONCLUSIONS: Our study suggests that DLBCL invasion is associated with CD31. The presence of CD31 in DLBCL lesions could represent a valuable target for treating central nervous system lymphoma and restoring CD8+ T-cell function.PMID:37193155 | PMC:PMC10182477
Source: Cell Research - May 16, 2023 Category: Cytology Authors: Zhengchang He Shaoxian Shen Yuyao Yi Lingli Ren Huan Tao Fujue Wang Yongqian Jia Source Type: research

Role of Fibrinogen in Type-2 Diabetes Mellitus with Diabetic Neuropathy and its Preliminary Mechanism
CONCLUSION: The increased concentration of FIB may be the cause of neuropathy, and its mechanism may be related to its promotion of inflammatory response, blood coagulation, and vascular stenosis.PMID:37165590 | DOI:10.2174/0929866530666230509140515
Source: Protein and Peptide Letters - May 11, 2023 Category: Biochemistry Authors: Wei-Li Gu Zhen-Hong Li Si-Qin Zhang Pian Ao Xiao-Bei Zhu Xin Zhao Xin-Yue Zhang Deng-Feng Zhang Xiao-Juan Huang Yu Jiang Li Wei Source Type: research

Inhibition of extranodal NK/T-cell lymphoma by Chiauranib through an AIF-dependent pathway and its synergy with L-asparaginase
This study demonstrates Chiauranib's positive efficacy toward NKTL through the activation of the AIF-dependent apoptosis pathway for the first time. The novel and multi-targets of Chiauranib and the synergistic effect with L-asparaginase may provide a promising therapy for NKTL patients.PMID:37160920 | DOI:10.1038/s41419-023-05833-w
Source: Cancer Control - May 10, 2023 Category: Cancer & Oncology Authors: Tianxiao Gao Jieye Huang Haofan Yin Jiajia Huang Jinye Xie Ti Zhou Wei Fan Xia Yang Guoquan Gao Zhiming Li Source Type: research

Comprehensive evaluation of mitochondrial redox profile, calcium dynamics, membrane integrity and apoptosis markers in a preclinical model of severe penetrating traumatic brain injury
Free Radic Biol Med. 2023 Feb 7:S0891-5849(23)00050-3. doi: 10.1016/j.freeradbiomed.2023.02.001. Online ahead of print.ABSTRACTTraumatic Brain Injury (TBI) is caused by the external physical assaults damages to the brain. It is a heterogeneous disorder that remains a leading cause of death and disability in the military and civilian population of the United States. Preclinical investigations of mitochondrial responses in TBI have ascertained that mitochondrial dysfunction is an acute indicator of cellular damage and plays a pivotal role in long-term injury progression through cellular excitotoxicity. The current study was ...
Source: Free Radical Biology and Medicine - February 9, 2023 Category: Biology Authors: Jignesh D Pandya Sudeep Musyaju Hiren R Modi Ying Cao William J Flerlage Linda Huynh Brittany Kociuba Nishant P Visavadiya Firas Kobeissy Kevin Wang Janice S Gilsdorf Anke H Scultetus Deborah A Shear Source Type: research

Tilianin extracted from Xiangqinglan () inhibits apoptosis induced by mitochondrial pathway and endoplasmic reticulum stress in H9c2 cells after oxygen-glucose deprivation/reoxygenation
CONCLUSIONS: Tilianin may inhibit OGD/R-induced H9c2 cell apoptosis mediated by mitochondrial pathway and endoplasmic reticulum stress, thus protecting cardiomyocytes.PMID:36639994 | DOI:10.19852/j.cnki.jtcm.20221111.001
Source: Journal of Traditional Chinese Medicine - January 14, 2023 Category: Complementary Medicine Authors: Jiang Wen Zhang Wei Zhang Yuxiang Yang Hao Pan Xiaomei Chen Qiang Chen Junhui Source Type: research