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Total 355 results found since Jan 2013.

HyDRA: gene prioritization via hybrid distance-score rank aggregation
Summary: Gene prioritization refers to a family of computational techniques for inferring disease genes through a set of training genes and carefully chosen similarity criteria. Test genes are scored based on their average similarity to the training set, and the rankings of genes under various similarity criteria are aggregated via statistical methods. The contributions of our work are threefold: (i) first, based on the realization that there is no unique way to define an optimal aggregate for rankings, we investigate the predictive quality of a number of new aggregation methods and known fusion techniques from machine lea...
Source: Bioinformatics - April 2, 2015 Category: Bioinformatics Authors: Kim, M., Farnoud, F., Milenkovic, O. Tags: SYSTEMS BIOLOGY Source Type: research

Limbic Encephalitis Exacerbations and Remissions Charted by Microglial PET Scan: A Case Study (P4.104)
CONCLUSIONS: C-11-PK11195 PET imaging can be useful in the diagnosis of limbic encephalitis and for monitoring response to treatment. MALT lymphoma may also be associated with autoimmune or paraneoplastic encephalitis, especially in individuals with other predisposing factors to autoimmune disorders, such as Tourette’s and autoimmune thyroid disease. The reduction in microglial activity with both IVIG and anti-psychotics supports previous findings that anti-psychotics may act through anti-inflammatory pathways.Disclosure: Dr. Shatz has received research support from Janssen Pharmaceutica. Dr. Chugani has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Shatz, R., Chugani, H. Tags: Aging, Dementia, Cognitive, and Behavioral Neurology: Rapidly Progressive and Inflammatory Dementias Source Type: research

Daucosterol protects neurons against oxygen–glucose deprivation/reperfusion-mediated injury by activating IGF1 signaling pathway
In this study, we investigated the effects of daucosterol on the survival of cultured cortical neurons after neurons were subjected to oxygen and glucose deprivation and simulated reperfusion (OGD/R) 2 2 OGD/R, oxygen and glucose deprivation and simulated reperfusion. , and determined the corresponding molecular mechanism. The results showed that post-treatment of daucosterol significantly reduced neuronal loss, as well as apoptotic rate and caspase-3 activity, displaying the neuroprotective activity. We also found that daucosterol increased the expression level of IGF1 protein, diminished the down-regulation of p-AKT 3 ...
Source: The Journal of Steroid Biochemistry and Molecular Biology - April 10, 2015 Category: Biochemistry Source Type: research

Neuroprotective Role of an N-acetyl Serotonin Derivative via Activation of Tropomyosin-related Kinase Receptor B after Subarachnoid Hemorrhage in a Rat Model.
This study is to investigate a potential role of HIOC on ameliorating early brain injury after experimental subarachnoid hemorrhage (SAH). One hundred and fifty-six adult male Sprague-Dawley rats were used. SAH model was induced by endovascular perforation. TrkB small interfering RNA (siRNA) or scramble siRNA was injected intracerebroventricularly 24hours before SAH. HIOC was administrated intracerebroventricularly 3hours after SAH and compared with brain-derived neurotrophic factor (BDNF). SAH grade and neurologic scores were evaluated for the outcome study. For the mechanism study, the expression of TrkB, phosphorylated ...
Source: Neurobiology of Disease - April 8, 2015 Category: Neurology Authors: Tang J, Hu Q, Chen Y, Liu F, Zheng Y, Tang J, Zhang J, Zhang JH Tags: Neurobiol Dis Source Type: research

Infertility etiologies are genetically and clinically linked with other diseases in single meta-diseases
The present review aims to ascertain whether different infertility etiologies share particular genes and/or molecular pathways with other pathologies and are associated with distinct and particular risks of later-life morbidity and mortality. In order to reach this aim, we use two different sources of information: (1) a public web server named DiseaseConnect (http://disease-connect.org) focused on the analysis of common genes and molecular mechanisms shared by diseases by integrating comprehensive omics and literature data; and (2) a literature search directed to find clinical comorbid relationships of infertility etiologi...
Source: Reproductive Biology and Endocrinology - April 15, 2015 Category: Endocrinology Authors: Juan TarínMiguel García-PérezToshio HamataniAntonio Cano Source Type: research

Paeoniflorin, a Monoterpene Glycoside, Protects the Brain from Cerebral Ischemic Injury via Inhibition of Apoptosis.
Abstract Paeoniflorin (PF) is a principal bioactive component, which exhibits many pharmacological effects, including protection against ischemic injury. This paper aimed to investigate the protective effect of PF both in vivo and in vitro. Middle cerebral artery occlusion (MCAO) was performed on male Sprague-Dawley (SD) rat for 2 h, and different doses of PF or vehicle were administered 2 h after reperfusion. Rats were sacrificed after 7 days treatment of PF/vehicle. PF treatment for 7 days ameliorated MCAO-induced neurological deficit and decreased the infarct area. Further study demonstrated that PF inhibited t...
Source: The American Journal of Chinese Medicine - May 17, 2015 Category: Complementary Medicine Authors: Zhang Y, Li H, Huang M, Huang M, Chu K, Xu W, Zhang S, Que J, Chen L Tags: Am J Chin Med Source Type: research

Central Nervous System Complications and Outcomes after Allogeneic Hematopoietic Stem Cell Transplantation
This retrospective study of 351 patients, who have undergone allogeneic hematopoietic stem cell transplantation between 2002 and 2011 at the University of Nebraska Medical Center, demonstrated 12% incidence of central nervous system complications. The most common complications included posterior reversible encephalopathy syndrome (40%), stroke or transient ischemic attack (24%), seizures (20%), and infection (9%). The 5-year overall survival was significantly lower among patients with versus without central nervous system complications (14% vs. 44%, p=0.0004).
Source: Clinical Lymphoma, Myeloma and Leukemia - June 18, 2015 Category: Hematology Authors: Vijaya Raj Bhatt, Vamshi Balasetti, Jagar J. Abduall, Smith Giri, James O. Armitage, Fausto R. Loberiza, R. Gregory Bociek, Philip J. Bierman, Lori J. Maness, Julie M. Vose, Pierre Fayad, Mojtaba Akhtari Source Type: research

E-075 neurosarcoidosis presenting as aneurysmal subarachnoid hemorrhage: an interesting case and novel treatment
Neurosarcoidosis, the term used for sarcoidosis involving the central nervous system, represents an uncommon form of sarcoidosis, found in a 5% of patients with systemic sarcoidosis. Clinically evident cerebrovascular involvement in neurosarcoidosis has been reported but appears to be an extremely rare manifestation of neurosarcoidosis. The literature describes these cerebral vasculopathic changes as areas of stenosis and/or vascular irregularity, with clinical manifestations including headache, ischemic stroke, and parenchymal hemorrhage. Neurosarcoidosis has even been described as the etiology for a case of moyamoya synd...
Source: Journal of NeuroInterventional Surgery - July 26, 2015 Category: Neurosurgery Authors: Gaughen, J. Tags: SNIS 12th Annual Meeting Electronic Poster Abstracts Source Type: research

Statistical methods for studying disease subtype heterogeneity
A fundamental goal of epidemiologic research is to investigate the relationship between exposures and disease risk. Cases of the disease are often considered a single outcome and assumed to share a common etiology. However, evidence indicates that many human diseases arise and evolve through a range of heterogeneous molecular pathologic processes, influenced by diverse exposures. Pathogenic heterogeneity has been considered in various neoplasms such as colorectal, lung, prostate, and breast cancers, leukemia and lymphoma, and non‐neoplastic diseases, including obesity, type II diabetes, glaucoma, stroke, cardiovascular d...
Source: Statistics in Medicine - December 1, 2015 Category: Statistics Authors: Molin Wang, Donna Spiegelman, Aya Kuchiba, Paul Lochhead, Sehee Kim, Andrew T. Chan, Elizabeth M. Poole, Rulla Tamimi, Shelley S. Tworoger, Edward Giovannucci, Bernard Rosner, Shuji Ogino Tags: Tutorial in Biostatistics Source Type: research

Neuroprotective Effects of Acetyl-L-Carnitine Against Oxygen-Glucose Deprivation-Induced Neural Stem Cell Death
Abstract Deprivation of oxygen and glucose is the main cause of neuronal cell death during cerebral infarction and can result in severe morbidity and mortality. In general, the neuroprotective therapies that are applied after ischemic stroke have been unsuccessful, despite many investigations. Acetyl-L-carnitine (ALCAR) plays an important role in mitochondrial metabolism and in modulating the coenzyme A (CoA)/acyl-CoA ratio. We investigated the protective effects of ALCAR against oxygen-glucose deprivation (OGD) in neural stem cells (NSCs). We measured cell viability, proliferation, apoptosis, and intracellular si...
Source: Molecular Neurobiology - December 8, 2015 Category: Neurology Source Type: research

Sjogren's syndrome with acute cerebellar ataxia and massive lymphadenopathy : a case report.
DISCUSSION: For patients with acute acquired cerebellar ataxia, immune-mediated cerebellar ataxia should be an important differential diagnosis aside from the more common causes like stroke or drugs. PMID: 24030041 [PubMed - indexed for MEDLINE]
Source: Acta Neurologica Taiwanica - December 12, 2015 Category: Neurology Tags: Acta Neurol Taiwan Source Type: research

EP3, Prostaglandin E2 Receptor Subtype 3, Associated with Neuronal Apoptosis Following Intracerebral Hemorrhage.
Abstract EP3 is prostaglandin E2 receptor subtype 3 and mediates the activation of several signaling pathways, changing in cAMP levels, calcium mobilization, and activation of phospholipase C. Previous studies demonstrated a direct role for EP3 in various neurodegenerative disorders, such as stroke and Alzheimer disease. However, the distribution and function of EP3 in ICH diseases remain unknown. Here, we demonstrate that EP3 may be involved in neuronal apoptosis in the processes of intracerebral hemorrhage (ICH). From the results of Western blot and immunohistochemistry, we obtained a significant up-regulation o...
Source: Cellular and Molecular Neurobiology - December 30, 2015 Category: Cytology Authors: Ni H, Shen J, Song Y, Cao M, Liu X, Huang J, Zhang W, Xie L, Ning X, Ke K Tags: Cell Mol Neurobiol Source Type: research

Cardiovascular Disease Among Survivors of Adult-Onset Cancer: A Community-Based Retrospective Cohort Study.
CONCLUSION: The magnitude of subsequent CVD risk varies according to cancer subtype and by the presence of CVRFs. Overall survival in survivors who develop CVD is poor, emphasizing the need for targeted prevention strategies for individuals at highest risk of developing CVD. PMID: 26834065 [PubMed - as supplied by publisher]
Source: Clinical Prostate Cancer - February 1, 2016 Category: Cancer & Oncology Authors: Armenian SH, Xu L, Ky B, Sun C, Farol LT, Pal SK, Douglas PS, Bhatia S, Chao C Tags: J Clin Oncol Source Type: research

Summary: International Kidney Cancer Symposium
Conclusions:  Ideal ischemia time is 20-25 minutes or less improves short and long term renal function.  >25 minutes carried 5 year risk of new onset stage 4 CKD No differences on GFR for cold vs. warm ischemia times Preoperative GFR and the percent of kidney preserved was a better predictor of post op GFR.  No ischemia preserves renal function better than warm. Longer cold ischemia times were equivalent to shorter warm ischemia times. Quality and quantity of the remaining kidney is associated with ultimate renal function. Robotics in RCC Surgery Gennady Bratslavsky, MD The...
Source: Kidney Cancer Association - December 15, 2011 Category: Urology & Nephrology Source Type: news

Pseudotumoral presentation of cerebral amyloid angiopathy-related inflammation
Conclusion: The identification of one or several nonenhancing space-occupying lesions, especially in elderly patients presenting with cognitive impairment, should raise suspicion for the pseudotumoral presentation of CAA-I and lead to T2*-GRE sequences. Perfusion MRI and MRS appear to be useful techniques for the differential diagnosis of this entity.
Source: Neurology - March 7, 2016 Category: Neurology Authors: Ronsin, S., Deiana, G., Geraldo, A. F., Durand-Dubief, F., Thomas-Maisonneuve, L., Formaglio, M., Desestret, V., Meyronet, D., Nighoghossian, N., Berthezene, Y., Honnorat, J., Ducray, F. Tags: MRI, MRS, Other cerebrovascular disease/ Stroke, Primary brain tumor ARTICLE Source Type: research