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Total 115 results found since Jan 2013.
Non-coding RNAs in cancer immunotherapy: Predictive biomarkers and targets
CONCLUSION: This review summarises important predictive ncRNA biomarkers that were reported in cancer patients treated with different immunotherapeutic modalities, including monoclonal antibodies, small molecule inhibitors, cancer vaccines and CAR-T cells. In addition, a concise discussion on forthcoming perspectives is provided, outlining technical approaches for the optimal utilisation of immunomodulatory ncRNA biomarkers as predictive tools and therapeutic targets.PMID:37735815 | DOI:10.1002/ctm2.1425
Source: Clinical Lung Cancer - September 22, 2023 Category: Cancer & Oncology Authors: Murad Alahdal Eyad Elkord Source Type: research
Potential applications of using tissue-specific EVs in targeted therapy and vaccinology
In conclusion, recently published works have shown that EVs could become biomarkers and modern vehicles of advanced drug forms.PMID:37660644 | DOI:10.1016/j.biopha.2023.115308
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 3, 2023 Category: Drugs & Pharmacology Authors: Tomasz P Lehmann Marta Golik Jolanta Olejnik Marianna Łukaszewska Dominika Markowska Martyna Dro żdżyńska Aleksander Kotecki Maciej G łowacki Pawe ł P Jagodziński Source Type: research
Recent advances and applications of peptide-agent conjugates for targeting tumor cells
CONCLUSIONS: This review highlights the potential of ACPs as a promising therapeutic option for cancer treatment, particularly through the use of peptide vaccines and peptide-drug conjugates. Despite the limitations of peptides, such as poor metabolic stability and low bioavailability, modified peptides show promise in addressing these challenges. Various mechanism of action of anticancer peptides. Modes of action against cancer cells including: inducing apoptosis by cytochrome c release, direct cell membrane lysis (necrosis), inhibiting angiogenesis, inducing autophagy-mediated cell death and immune cell regulation.PMID:3...
Source: Cell Research - August 15, 2023 Category: Cytology Authors: Vahab Alamdari-Palangi Khojaste Rahimi Jaberi Mahshid Shahverdi Yasaman Naeimzadeh Amir Tajbakhsh Sahar Khajeh Vahid Razban Jafar Fallahi Source Type: research
Humoral Immunity After COVID-19 Vaccination in Chronic Lymphocytic Leukemia and Other Indolent Lymphomas: A Single-Center Observational Study
CONCLUSION: Antibody response is lower in patients with indolent lymphomas compared to the general population. Lower Ab seropositivity was found in patients with a history of anti-leukemic agent therapy or those immunized with Pfizer vaccine. This data suggests that Moderna vaccination may confer a greater degree of immunity against SARS-CoV-2 in patients with indolent lymphomas.PMID:37141401 | DOI:10.1093/oncolo/oyad121
Source: The Oncologist - May 4, 2023 Category: Cancer & Oncology Authors: Peter G Doukas Frederique St Pierre Reem Karmali Xinlei Mi Jennifer Boyer Mariana Nieves Michael G Ison Jane N Winter Leo I Gordon Shuo Ma Source Type: research
Risk Factors and Trends for HPV-Associated Subsequent Malignant Neoplasms among Adolescent and Young Adult Cancer Survivors
CONCLUSIONS: HPV-SMN in AYA survivors are driven by oropharyngeal cancers despite temporal declines in oropharyngeal-SMN. Hispanic survivors are at risk for cervical-SMN relative to the general population.IMPACT: Encouraging HPV vaccination and cervical and oral cancer screenings may reduce HPV-SMN burden among AYA survivors.PMID:37071501 | DOI:10.1158/1055-9965.EPI-22-0826
Source: Cancer Control - April 18, 2023 Category: Cancer & Oncology Authors: Judy Y Ou Natalie Bennion Kellee Parker Douglas Fair Heidi A Hanson Deanna Kepka Echo L Warner Joemy M Ramsay Heydon K Kaddas Anne C Kirchhoff Source Type: research
Fight Aging! Newsletter, March 20th 2023
This study also provides the potential for de novo generation of complex organs in vivo.
T Cells May Play a Role in the Brain Inflammation Characteristic of Neurodegenerative Conditions
https://www.fightaging.org/archives/2023/03/t-cells-may-play-a-role-in-the-brain-inflammation-characteristic-of-neurodegenerative-conditions/
Alzheimer's disease, and other forms of neurodegenerative condition, are characterized by chronic inflammation in brain tissue. Unresolved inflammatory signaling is disruptive of tissue structure and function. Here, researchers provide evidence for T cells to become involved in this...
Source: Fight Aging! - March 19, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Enhanced antitumor activity of a novel, oral, helper epitope-containing WT1 protein vaccine in a model of murine leukemia
CONCLUSIONS: B. longum 420/2656 combination further accelerated antitumor activity that relies on WT1-specific CTLs in the tumor compared with B. longum 420.PMID:36803483 | DOI:10.1186/s12885-023-10547-5
Source: Methods of Information in Medicine - February 21, 2023 Category: Information Technology Authors: Hikaru Minagawa Yoshiko Hashii Hiroko Nakajima Fumihiro Fujiki Soyoko Morimoto Jun Nakata Toshiro Shirakawa Takane Katayama Akihiro Tsuboi Keiichi Ozono Source Type: research
The case of T-ALL presenting with NK phenotype after COVID-19 vaccination
We present a 55-year-old man who had cervical lymph node swelling post vaccination for COVID-19. Hematological malignancy was suspected due to the presence of atypical lymphoid cells with an elevated IL-2R in laboratory data. Tumor cells were positive for CD7, CD56, cyCD3, and terminal deoxynucleotidyl transferase (TdT) evidenced through flow cytometry of the bone marrow and the lymph node. The histopathological findings showed monotonous tumor cell proliferation, the cells being positive for CD3 and TdT in the bone marrow and they were positive for CD3, TdT, and CD56 in lymph node. Even though these findings suggested NK-...
Source: Cell Research - January 27, 2023 Category: Cytology Authors: Eriko Yanagida Akira Kubota Hiroaki Miyoshi Koichi Ohshima Toshiro Kawakita Toshihiko Murayama Source Type: research
Cancer statistics, 2023
CA Cancer J Clin. 2023 Jan;73(1):17-48. doi: 10.3322/caac.21763.ABSTRACTEach year, the American Cancer Society estimates the numbers of new cancer cases and deaths in the United States and compiles the most recent data on population-based cancer occurrence and outcomes using incidence data collected by central cancer registries and mortality data collected by the National Center for Health Statistics. In 2023, 1,958,310 new cancer cases and 609,820 cancer deaths are projected to occur in the United States. Cancer incidence increased for prostate cancer by 3% annually from 2014 through 2019 after two decades of decline, tra...
Source: Clinical Prostate Cancer - January 12, 2023 Category: Cancer & Oncology Authors: Rebecca L Siegel Kimberly D Miller Nikita Sandeep Wagle Ahmedin Jemal Source Type: research
