Recent advances and applications of peptide-agent conjugates for targeting tumor cells

CONCLUSIONS: This review highlights the potential of ACPs as a promising therapeutic option for cancer treatment, particularly through the use of peptide vaccines and peptide-drug conjugates. Despite the limitations of peptides, such as poor metabolic stability and low bioavailability, modified peptides show promise in addressing these challenges. Various mechanism of action of anticancer peptides. Modes of action against cancer cells including: inducing apoptosis by cytochrome c release, direct cell membrane lysis (necrosis), inhibiting angiogenesis, inducing autophagy-mediated cell death and immune cell regulation.PMID:37581648 | DOI:10.1007/s00432-023-05144-9

Source: Cell Research - August 15, 2023 Category: Cytology Authors: Vahab Alamdari-Palangi Khojaste Rahimi Jaberi Mahshid Shahverdi Yasaman Naeimzadeh Amir Tajbakhsh Sahar Khajeh Vahid Razban Jafar Fallahi Source Type: research