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Total 28070 results found since Jan 2013.

Synthesis and Anticancer Activity of Phosphinoylated and Phosphonoylated N-Heterocycles Obtained by the Microwave-Assisted Palladium Acetate-Catalyzed Hirao Reaction
Chemistry. 2023 Sep 15:e202302465. doi: 10.1002/chem.202302465. Online ahead of print.ABSTRACTA literature survey showed that different derivatives with the 9-phenyl-9H-carbazole or the dihydroindoline scaffold may be of biological activity including cytotoxic effect. Driven by this experience, we wished to synthesize P-functionalized derivatives of the above mentioned N-heterocycles. Three N-heterocycles, 9-(4-bromophenyl)-9H-carbazole, 3-bromo-9-phenyl-9H-carbazole and 1-(5-bromoindolin-1-yl)ethan-1-one were coupled with dialkyl phosphites and diarylphosphine oxides using Pd(OAc)2 (10%) as the catalyst precursor and trie...
Source: Chemistry - September 15, 2023 Category: Chemistry Authors: Bianka Husz ár Ren áta Szolga Szilvia B ősze Rita Ol áhné Szabó Andr ás Simon Konstantin Karaghiosoff M átyás Czugler L ászló Drahos Gy örgy Keglevich Source Type: research

LC-PDA-QTof-MS characterization of the stress degradation products of Zanubrutinib: A novel BTK inhibitor
This study provides comprehensive information on the inherent stability of ZAN which will be useful in the drug development and manufacturing processes.PMID:37713985 | DOI:10.1016/j.jpba.2023.115714
Source: Biomed Res - September 15, 2023 Category: Research Authors: Murali Mohan Bhandi Debasish Swain Srinivas Ragampeta Mohana Krishna Reddy Mudiam Source Type: research

Podophyllotoxin reduces the aggressiveness of human oral squamous cell carcinoma through myeloid cell leukemia ‑1
Int J Mol Med. 2023 Nov;52(5):103. doi: 10.3892/ijmm.2023.5306. Epub 2023 Sep 15.ABSTRACTPodophyllotoxin (PPT), which is derived from the podophyllum plant, exhibits marked cytotoxic effects against cancer cells; however, the precise molecular mechanism underlying its activity against human oral squamous cell carcinoma (OSCC) has not been elucidated. In the present study, the mechanism by which PPT induced cytotoxicity in two OSCC cell lines, HSC3 and HSC4, was determined. The effects of PPT on cytotoxicity in HSC3 and HSC4 cells were analyzed using Annexin V/PI double staining, Sub‑G1 analysis, soft agar assays, western...
Source: International Journal of Molecular Medicine - September 15, 2023 Category: Molecular Biology Authors: Hyun-Ju Yu Ji-Ae Shin Su-Jung Choi Sung-Dae Cho Source Type: research

A Patient Presenting for Dental Extraction After Completion of Chemotherapy
Dent Clin North Am. 2023 Oct;67(4):667-670. doi: 10.1016/j.cden.2023.05.020. Epub 2023 Jun 18.ABSTRACTAcute myeloid leukemia (AML) presents several oral manifestations, including gingival hyperplasia, pale mucosa, poor wound healing, petechiae, ecchymoses, candidiasis, recurrent herpes infection, and ulcerations in the oral mucosa. Chemotherapy is the first-line treatment of AML. Common dental complications of chemotherapy include mucositis, infections secondary to profound bone marrow aplasia, and gingival bleeding. When treating patients with AML, preparing a comprehensive treatment plan is essential to help minimize the...
Source: Herpes - September 15, 2023 Category: Infectious Diseases Authors: Walter W Hong Irene H Kim Brad M Hong Sophia Oak Mel Mupparapu Source Type: research

Acute Myeloid Leukemia Causes T Cell Exhaustion and Depletion in a Humanized Graft-versus-Leukemia Model
J Immunol. 2023 Sep 15:ji2300111. doi: 10.4049/jimmunol.2300111. Online ahead of print.ABSTRACTAllogeneic hematopoietic stem cell transplantation (alloSCT) is, in many clinical settings, the only curative treatment for acute myeloid leukemia (AML). The clinical benefit of alloSCT greatly relies on the graft-versus-leukemia (GVL) effect. However, AML relapse remains the top cause of posttransplant death; this highlights the urgent need to enhance GVL. Studies of human GVL have been hindered by the lack of optimal clinically relevant models. In this article, we report, the successful establishment of a novel (to our knowledg...
Source: Journal of Immunology - September 15, 2023 Category: Allergy & Immunology Authors: Bei Jia Chenchen Zhao Kentaro Minagawa Hiroko Shike David F Claxton W Christopher Ehmann Witold B Rybka Shin Mineishi Ming Wang Todd D Schell K Sandeep Prabhu Robert F Paulson Yi Zhang Leonard D Shultz Hong Zheng Source Type: research

Study the effect of recombinant leukemia inhibitory factor on maintenance of pregnancy and frequency of regulatory T cells in abortion-prone mice
Int Immunopharmacol. 2023 Sep 13;124(Pt A):110908. doi: 10.1016/j.intimp.2023.110908. Online ahead of print.ABSTRACTRecurrent spontaneous abortion (RSA) can have a significant impact on a woman's quality of life. Understanding the mechanisms behind abortion is crucial for developing potential treatments. Among various models of abortion, the CBA/J(♀) × DBA/2J(♂) model stands out as the most extensively studied. This model reveals the influence of an altered immune system on resorption during pregnancy. The leukemia inhibitory factor (LIF) holds considerable importance as a secretory glycoprotein essential for successf...
Source: International Immunopharmacology - September 15, 2023 Category: Allergy & Immunology Authors: Hossein Ansariniya Hossein Hadinedoushan Fateme Zare Farah Idali Mahdi Shabani Nariman Mosaffa Source Type: research

A novel KMT2A::DCP1B rearrangement in chronic neutrophilic leukemia
Int J Lab Hematol. 2023 Sep 15. doi: 10.1111/ijlh.14173. Online ahead of print.NO ABSTRACTPMID:37712389 | DOI:10.1111/ijlh.14173
Source: International Journal of Laboratory Hematology - September 15, 2023 Category: Hematology Authors: Lei Yang Xiaoshan Yang Yun Zhuang Jue Wang Xiaojun Chen Wentao Hu Dan Shan Rong Rong Xin Zhou Sheng Xiao Source Type: research

Targeting SDCBP2 in acute myeloid leukemia
Cell Signal. 2023 Sep 13:110889. doi: 10.1016/j.cellsig.2023.110889. Online ahead of print.ABSTRACTAcute myeloid leukemia (AML) remains a biologically heterogeneous disease with high morbidity and mortality under the existing treatment strategies. Our previous study showed that E2A might be a potential therapeutic target for AML, but the underlying mechanism was unclear. Here, we found that SDCBP2 might be a target gene of E2A through RNA-seq combined ChIP-seq screening. This was also demonstrated by Co-IP experiment. Furthermore, the expression of E2A and SDCBP2 were increased in both AML cell lines and patient samples. D...
Source: Cellular Signalling - September 15, 2023 Category: Cytology Authors: Yan Du Lan-Lan Li Feihu Chen Yan Du Source Type: research

Mitotic perturbation is a key mechanism of action of decitabine in myeloid tumor treatment
Cell Rep. 2023 Sep 12:113098. doi: 10.1016/j.celrep.2023.113098. Online ahead of print.ABSTRACTDecitabine (DAC) is clinically used to treat myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). Our genome-wide CRISPR-dCas9 activation screen using MDS-derived AML cells indicates that mitotic regulation is critical for DAC resistance. DAC strongly induces abnormal mitosis (abscission failure or tripolar mitosis) in human myeloid tumors at clinical concentrations, especially in those with TP53 mutations or antecedent hematological disorders. This DAC-induced mitotic disruption and apoptosis are significantly attenu...
Source: Cancer Control - September 15, 2023 Category: Cancer & Oncology Authors: Tomohiro Yabushita Takumi Chinen Atsuya Nishiyama Shuhei Asada Ruka Shimura Tomoya Isobe Keita Yamamoto Naru Sato Yutaka Enomoto Yosuke Tanaka Tomofusa Fukuyama Hitoshi Satoh Keiko Kato Kaori Saitoh Takamasa Ishikawa Tomoyoshi Soga Yasuhito Nannya Tatsuo Source Type: research

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