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Fight Aging! Newsletter, June 27th 2016
In conclusion, we showed for the first time that 7-KC induces oxidative stress via lysosomal dysfunction, resulting in exacerbation of calcification. CHIMERIC ANTIGEN RECEPTOR CANCER THERAPIES CAN NOW TARGET SOLID TUMORS https://www.fightaging.org/archives/2016/06/chimeric-antigen-receptor-cancer-therapies-can-now-target-solid-tumors/ If the research community is to win in the fight to cure cancer, and win soon enough to matter for all of us, then the focus must be on technology platforms that can be easily and cheaply adapted to many different types of cancer. The biggest strategic problem in the field is tha...
Source: Fight Aging! - June 26, 2016 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Autologous hematopoietic stem cell transplantation following high-dose chemotherapy for nonrhabdomyosarcoma soft tissue sarcomas.
CONCLUSIONS: The limited data of a single RCT with an unclear risk of bias and moderate to high quality evidence showed no survival advantage for HDCT. If this treatment is offered it should only be given after careful consideration on an individual person basis and possibly only as part of a well-designed RCT. PMID: 28407197 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - April 13, 2017 Category: Journals (General) Authors: Peinemann F, Enk H, Smith LA Tags: Cochrane Database Syst Rev Source Type: research

Fight Aging! Newsletter, January 15th 2018
This study is the longest, prospective randomized controlled trial that has documented the physiological effects of supervised, structured exercise training in a group of sedentary but healthy middle-aged adults. The key finding is that 2 years of exercise training performed for at least 30 minutes, 4 to 5 days per week, and including at least 1 high-intensity interval session per week results in a significant reduction in LV chamber and myocardial stiffness. The use of high-resolution, invasively measured LV pressure-volume curves and comparison with an attention control group enhances the confidence in this conclusion. T...
Source: Fight Aging! - January 14, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Hematological Side Effects of Immune Checkpoint Inhibitors: The Example of Immune-Related Thrombocytopenia
Conclusion Hem-irAEs are potentially life-threatening complications of ICIs that require a high level of clinical suspicion. Ir-TCP is amongst the most frequently reported hem-irAEs. Due to its low incidence and the lack of specific diagnostic criteria, ir-TCP may be underdiagnosed and possibly underreported. The diagnosis is based on exclusion of other causes of TCP together with clinical features that suggest an immune event such as the refractoriness to platelet transfusions and response to corticosteroids. During clinical development, a systematic analysis of ir-TCP cases at clinical study and program level is of outm...
Source: Frontiers in Pharmacology - April 25, 2019 Category: Drugs & Pharmacology Source Type: research

Should critically ill children with acute respiratory failure be treated with surfactant?
Scenario A 9-year-old child with relapsed acute lymphoblastic leukaemia postbone marrow transplant was admitted to the children's intensive care unit (ICU) for non-neutropenic fever with worsening respiratory distress that required mechanical ventilation. Despite broad-spectrum antimicrobials, serial chest radiographs showed worsening bilateral infiltrates and increasing mechanical ventilatory requirements. As the registrar in the unit, you wondered if intratracheal surfactant would be beneficial in treating this child with acute respiratory failure. Structured clinical question In critically ill children with acute respir...
Source: Archives of Disease in Childhood - June 11, 2013 Category: Pediatrics Authors: Ng, Z. M., Kavalloor, N. V., Lee, J. H. Tags: ADC Archimedes, Oncology, Epidemiologic studies, Bronchiolitis, Pneumonia (infectious disease), TB and other respiratory infections, Child health, Radiology, Adult intensive care, Bronchitis, Mechanical ventilation, Pneumonia (respiratory medicine), Clini Source Type: research

The experience of acute leukaemia in adult patients: A qualitative thematic synthesis.
CONCLUSIONS: Results from this thematic synthesis are indicative of the impact of acute leukaemia on patients' lives and the processes they use to make sense and accommodate the illness in their life. Increasing our understanding of these processes is warranted to improve patient care. PMID: 23871393 [PubMed - as supplied by publisher]
Source: European Journal of Oncology Nursing - July 17, 2013 Category: Nursing Authors: Papadopoulou C, Johnston B, Themessl-Huber M Tags: Eur J Oncol Nurs Source Type: research

The experience of acute leukaemia in adult patients: A qualitative thematic synthesis
Conclusions: Results from this thematic synthesis are indicative of the impact of acute leukaemia on patients' lives and the processes they use to make sense and accommodate the illness in their life. Increasing our understanding of these processes is warranted to improve patient care.
Source: European Journal of Oncology Nursing - July 22, 2013 Category: Cancer & Oncology Authors: Constantina Papadopoulou, Bridget Johnston, Markus Themessl-Huber Source Type: research

The impact of allogeneic stem cell transplantation on the natural course of poor-risk chronic lymphocytic leukemia as defined by the EBMT consensus criteria: a retrospective donor versus no donor comparison
Conclusion This study provides first comparative evidence that alloSCT may have the potential to improve the natural course of poor-risk CLL as defined by the EBMT criteria.
Source: Annals of Oncology - December 19, 2013 Category: Cancer & Oncology Authors: Herth, I., Dietrich, S., Benner, A., Hegenbart, U., Rieger, M., Stadtherr, P., Bondong, A., Tran, T. H., Weide, R., Hensel, M., Knauf, W., Franz-Werner, J., Welslau, M., Procaccianti, M., Gorner, M., Meissner, J., Luft, T., Schonland, S., Witzens-Harig, M Tags: original articles Source Type: research

Aerobic physical exercise for adult patients with haematological malignancies.
CONCLUSIONS: There is no evidence for differences in mortality between the exercise and control groups. Physical exercise added to standard care can improve quality of life, especially physical functioning, depression and fatigue. Currently, there is inconclusive evidence regarding anxiety, physical performance, serious adverse events and adverse events.We need further trials with more participants and longer follow-up periods to evaluate the effects of exercise intervention for people suffering from haematological malignancies. Furthermore, we need trials with overall survival as the primary outcome to determine whether t...
Source: Cochrane Database of Systematic Reviews - November 11, 2014 Category: Journals (General) Authors: Bergenthal N, Will A, Streckmann F, Wolkewitz KD, Monsef I, Engert A, Elter T, Skoetz N Tags: Cochrane Database Syst Rev Source Type: research

Question 2: What are the risk factors for antibiotic resistant Gram-negative bacteraemia in children with cancer?
Scenario A 5-year-old girl with acute lymphoblastic leukaemia is receiving empirical intravenous antibiotic treatment for febrile neutropenia. On day 2 of her admission you are notified from the microbiology laboratory that she has a blood culture positive with a Gram-negative bacillus. You wonder if she has risk factors for antibiotic resistant Gram-negative bacteraemia and if her empirical antibiotic therapy should be adjusted. Structured clinical question In a child with cancer (patient) what risk factors (‘intervention’) affect probability of growth of an antibiotic resistant Gram-negative organism in blood...
Source: Archives of Disease in Childhood - August 18, 2015 Category: Pediatrics Authors: Haeusler, G. M., Levene, I. Tags: ADC Archimedes, Oncology, Epidemiologic studies, Drugs: infectious diseases, Child health, Screening (epidemiology), Screening (public health) Source Type: research

Cyanobacteria as a Source for Novel Anti-Leukemic Compounds.
We report that cyanobacteria harbor specific anti-leukemic compounds since several studied strains induced apoptosis against AML cells but were inactive against non-malignant cells like hepatocytes. We noted that particularly benthic strains from the Baltic Sea, such as Anabaena sp., were especially potential AML apoptosis inducers. Taken together, this review and re-analysis of data demonstrates the power of maintaining large culture collections for the search for novel bioactivities, and also how anti-AML activity in cyanobacteria can be revealed by relatively simple and low-cost assays. PMID: 26306745 [PubMed - as ...
Source: Current Pharmaceutical Biotechnology - August 26, 2015 Category: Biotechnology Authors: Humisto A, Herfindal L, Jokela J, Karkman A, Bjørnstad R, Choudhury RR, Sivonen K Tags: Curr Pharm Biotechnol Source Type: research

Relative Contributions of Agricultural Drift, Para-Occupational, and Residential Use Exposure Pathways to House Dust Pesticide Concentrations: Meta-Regression of Published Data
Conclusion: Our quantification of the relative contributions of pesticide exposure pathways in agricultural populations could improve exposure assessments in epidemiologic studies. The meta-regression models can be updated when additional data become available. Citation: Deziel NC, Beane Freeman LE, Graubard BI, Jones RR, Hoppin JA, Thomas K, Hines CJ, Blair A, Sandler DP, Chen H, Lubin JH, Andreotti G, Alavanja MC, Friesen MC. 2017. Relative contributions of agricultural drift, para-occupational, and residential use exposure pathways to house dust pesticide concentrations: meta-regression of published data. Environ Heal...
Source: EHP Research - March 1, 2017 Category: Environmental Health Authors: Web Admin Tags: Reviews March 2017 Source Type: research

Comparison of first-line chemotherapy including escalated BEACOPP versus chemotherapy including ABVD for people with early unfavourable or advanced stage Hodgkin lymphoma.
CONCLUSIONS: This meta-analysis provides moderate- to high-quality evidence that adult patients between 16 and 60 years of age with early unfavourable and advanced stage HL benefit regarding OS and PFS from first-line chemotherapy including escalated BEACOPP. The proven benefit in OS for patients with advanced HL is a new finding of this updated review due to the inclusion of the results from the EORTC 20012 trial. Furthermore, there is only low-quality evidence of a difference in the total number of secondary malignancies, as the follow-up period might be too short to detect meaningful differences. Low-quality evidence al...
Source: Cochrane Database of Systematic Reviews - May 25, 2017 Category: General Medicine Authors: Skoetz N, Will A, Monsef I, Brillant C, Engert A, von Tresckow B Tags: Cochrane Database Syst Rev Source Type: research

Adherence and Coping Strategies in Outpatients With Chronic Myeloid Leukemia Receiving Oral Tyrosine Kinase Inhibitors.
CONCLUSIONS: The low adherence rate of 51% most likely resulted from using the Basel Assessment of Adherence Scale as the questionnaire of choice. The relevance of spirituality and search for meaning as main coping strategies has not been shown previously in outpatients with CML. Most patients wish to obey medical instructions accurately and put trust in their oncologists; this introduces a resource that should gain relevance considering the increasing number of oral anticancer drugs.
. IMPLICATIONS FOR NURSING: Nurses are encouraged to routinely assess adherence and spiritual needs in outpatients with CML. Spiritua...
Source: Oncology Nursing Forum - October 22, 2017 Category: Nursing Authors: Hefner J, Csef EJ, Kunzmann V Tags: Oncol Nurs Forum Source Type: research

How to Plan and Carry Out a Simple Self-Experiment, a Single Person Trial of Chemotherapeutic Senolytic Drug Candidates
The objective here is a set of tests that anyone can run without the need to involve a physician, as that always adds significant time and expense. Since we are really only interested in the identification of large and reliable effects as the result of an intervention, we can plausibly expect a collection of cheaper and easier measures known to correlate with age to be useful. Once that hill has been climbed, then decide whether or not to go further - don't bite off more than is easy to chew for a first outing. From an earlier exploration of likely tests, I picked the following items on the basis of a likely connect...
Source: Fight Aging! - January 12, 2018 Category: Research Authors: Reason Tags: Self-Experimentation Source Type: blogs