Question 2: What are the risk factors for antibiotic resistant Gram-negative bacteraemia in children with cancer?

Scenario A 5-year-old girl with acute lymphoblastic leukaemia is receiving empirical intravenous antibiotic treatment for febrile neutropenia. On day 2 of her admission you are notified from the microbiology laboratory that she has a blood culture positive with a Gram-negative bacillus. You wonder if she has risk factors for antibiotic resistant Gram-negative bacteraemia and if her empirical antibiotic therapy should be adjusted. Structured clinical question In a child with cancer (patient) what risk factors (‘intervention’) affect probability of growth of an antibiotic resistant Gram-negative organism in blood culture (outcome) in comparison to growth of a sensitive Gram-negative organism (comparison). Search Medline was searched via the Healthcare Databases Advanced Search interface (1950 to present, limited to publications in English) using the search terms: (cancer OR oncolog*) AND ((antimicrob* AND resistan*) OR (antibiotic* AND resistan*) OR MDR OR ((multidrug OR multi-drug) AND resistan*) OR MRO OR...
Source: Archives of Disease in Childhood - Category: Pediatrics Authors: Tags: ADC Archimedes, Oncology, Epidemiologic studies, Drugs: infectious diseases, Child health, Screening (epidemiology), Screening (public health) Source Type: research