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Cancer: Colorectal Cancer
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Total 741 results found since Jan 2013.
ctDNA-guided adjuvant treatment after radical-intent treatment of metastatic spread from colorectal cancer-the first interim results from the OPTIMISE study
CONCLUSION: The study was proven to be feasible and continues in the planned large-scale phase II trial. Results from the OPTIMISE study will potentially optimize the adjuvant treatment of patients undergoing radical-intent treatment of mCRC, thereby improving survival and reducing chemotherapy-related toxicity.PMID:37738268 | DOI:10.1080/0284186X.2023.2259083
Source: Acta Oncologica - September 22, 2023 Category: Cancer & Oncology Authors: Louise Bach Callesen Torben Fr østrup Hansen Rikke Fredslund Andersen Niels Pallisgaard Stine Kramer Sven Schlander S øren Rafael Rafaelsen Anders Kindberg Boysen Lars Henrik Jensen Anders Jakobsen Karen-Lise Garm Spindler Source Type: research
Synchronous rectal adenocarcinoma and intestinal mantle cell lymphoma: A case report
CONCLUSION: Synchronous rectal adenocarcinoma and intestinal MCL presenting as multiple lymphomatous polyposis are extremely rare. MCL is often discovered fortuitously when rectal cancer is diagnosed. The coexistence of these tumors poses treatment challenges.PMID:37727717 | PMC:PMC10506007 | DOI:10.12998/wjcc.v11.i24.5772
Source: Clinical Colorectal Cancer - September 20, 2023 Category: Cancer & Oncology Authors: Kim-Van Vu Nguyen-Van Trong Nguyen-Thi Khuyen Do Huyen Nga Hoang Anh Nguyen Tien Trung Pham Trung Thong Nguyen Minh Duc Source Type: research
Cancers, Vol. 15, Pages 4651: Is Insulin Receptor Substrate4 (IRS4) a Platform Involved in the Activation of Several Oncogenes?
Miguel A. Ortega
The IRS (insulin receptor substrate) family of scaffold proteins includes insulin receptor substrate-4 (IRS4), which is expressed only in a few cell lines, including human kidney, brain, liver, and thymus and some cell lines. Its N-terminus carries a phosphotyrosine-binding (PTB) domain and a pleckstrin homology domain (PH), which distinguishes it as a member of this family. In this paper, we collected data about the molecular mechanisms that explain the relevance of IRS4 in the development of cancer and identify IRS4 differences that distinguish it from IRS1 and IRS2. Search engines and different dat...
Source: Cancers - September 20, 2023 Category: Cancer & Oncology Authors: Luis G. Guijarro Francisco Javier Justo Bermejo Diego Liviu Boaru Patricia De Castro-Martinez Diego De Leon-Oliva Oscar Fraile-Mart ínez Cielo Garcia-Montero Melchor Alvarez-Mon Mar ía del Val Toledo-Lobo Miguel A. Ortega Tags: Review Source Type: research
PNIPAM-stabilized cubosomes as fusogenic delivery nanovectors for anticancer applications
Colloids Surf B Biointerfaces. 2023 Sep 9;231:113532. doi: 10.1016/j.colsurfb.2023.113532. Online ahead of print.ABSTRACTIn recent years, lipid cubic nanoparticles have emerged as promising nanocarriers for drug delivery, due to the several advantages they exhibit with respect to other lipid systems. Here, we report on lipid cubic nanoparticles stabilized by PNIPAM-based amphiphilic block copolymers, specifically, poly(N, N-dimethylacrylamide)-block-poly(N-isopropylacrylamide) (PDMA-b-PNIPAM), as a new class of drug delivery systems (DDS). In vitro studies on the internalization efficiency of the DDS towards two types of h...
Source: Colloids and Surfaces - September 18, 2023 Category: Biotechnology Authors: Arianna Balestri Laure Gibot Heinz Amenitisch Lorenzo Cervelli Costanza Montis Barbara Lonetti Debora Berti Source Type: research
Label-free drug response evaluation of human derived tumor spheroids using three-dimensional dynamic optical coherence tomography
This study aims at demonstrating label-free drug-response-patterns assessment of different tumor spheroids and drug types by dynamic optical coherence tomography (D-OCT). The study involved human breast cancer (MCF-7) and colon cancer (HT-29) spheroids. The MCF-7 and HT-29 spheroids were treated with paclitaxel (Taxol; PTX) and the active metabolite of irinotecan SN-38, respectively. The drugs were applied with 0 (control), 0.1, 1, and 10 μM concentrations and the treatment durations were 1, 3, and 6 days. A swept-source OCT microscope equipped with a repeated raster scanning protocol was used to scan the spheroids. Logar...
Source: Cancer Control - September 16, 2023 Category: Cancer & Oncology Authors: Ibrahim Abd El-Sadek Larina Tzu-Wei Shen Tomoko Mori Shuichi Makita Pradipta Mukherjee Antonia Lichtenegger Satoshi Matsusaka Yoshiaki Yasuno Source Type: research
PET/CT in assessment of colorectal liver metastases: a comprehensive review with emphasis on < sup > 18 < /sup > F-FDG
Clin Exp Metastasis. 2023 Sep 8. doi: 10.1007/s10585-023-10231-9. Online ahead of print.ABSTRACTApproximately 25% of those who are diagnosed with colorectal cancer will develop colorectal liver metastases (CRLM) as their illness advances. Despite major improvements in both diagnostic and treatment methods, the prognosis for patients with CRLM is still poor, with low survival rates. Accurate employment of imaging methods is critical in identifying the most effective treatment approach for CRLM. Different imaging modalities are used to evaluate CRLM, including positron emission tomography (PET)/computed tomography (CT). Amon...
Source: Clinical Colorectal Cancer - September 8, 2023 Category: Cancer & Oncology Authors: Mahdi Zirakchian Zadeh Source Type: research
Molecules, Vol. 28, Pages 6424: Green Synthesis of Silver Nanoparticles Derived from Papaver rhoeas L. Leaf Extract: Cytotoxic and Antimicrobial Properties
Beylerli
In the last few decades, the search for metal nanoparticles as an alternative to cancer treatments and antibiotics has increased. In this article, the spectroscopic (ultraviolet&ndash;visible (UV-vis), electron-dispersing X-ray (EDX), and Fourier transform infrared (FT-IR)), microscopic (field emission scanning electron microscope (FE-SEM), transmission electron microscope (TEM), and atomic force microscope (AFM)), structural (X-ray diffractometer (XRD) and zetasizer), and analytic (thermogravimetric/differential thermal analyzer (TGA-DTA)) characterization of the silver nanoparticles (AgNPs) produced...
Source: Molecules - September 4, 2023 Category: Chemistry Authors: Polat İpek Re şit Yıldız Mehmet F ırat Baran Abdulkerim Hatipo ğlu Ay şe Baran Albert Sufianov Ozal Beylerli Tags: Article Source Type: research
Preclinical evaluation of a dual-receptor targeted tracer < sup > 68 < /sup > GaGa-HX01 in 10 different subcutaneous and orthotopic tumor models
CONCLUSIONS: [68Ga]Ga-HX01, as a dual target imaging agent, exhibited superior in vivo performance in different subcutaneous and orthotopic mice models of human tumors over [18F]FDG and its respectively mono-receptor targeted agents, which warrants the future clinical translation for tumor imaging.PMID:37642706 | DOI:10.1007/s00259-023-06412-z
Source: Molecular Medicine - August 29, 2023 Category: Molecular Biology Authors: Xiaoying Lv Xiangming Song Yu Long Dexing Zeng Xiaoli Lan Yongkang Gai Source Type: research
Differences and Similarities between Colorectal Cancer Cells and Colorectal Cancer Stem Cells: Molecular Insights and Implications
ACS Omega. 2023 Aug 9;8(33):30145-30157. doi: 10.1021/acsomega.3c02681. eCollection 2023 Aug 22.ABSTRACTMalignant tumors are formed by diverse groups of cancer cells. Cancer stem cells (CSCs) are a subpopulation of heterogeneous cells identified in tumors that have the ability to self-renew and differentiate. Colorectal cancer (CRC), the third most frequent malignant tumor, is progressively being supported by evidence suggesting that CSCs are crucial in cancer development. We aim to identify molecular differences between CRC cells and CRC CSCs, as well as the effects of those differences on cell behavior in terms of migrat...
Source: Cancer Control - August 28, 2023 Category: Cancer & Oncology Authors: Derya Erisik Berrin Ozdil Eda Acikgoz Cemile Sinem Asker Abdikan Taha Kadir Yesin Huseyin Aktug Source Type: research
Prognostic Value of Artificial Intelligence-Driven, Computed Tomography-Based, Volumetric Assessment of the Volume and Density of Muscle in Patients With Colon Cancer
CONCLUSION: Preoperative volumetric sarcopenia and myosteatosis, automatically assessed from pre-contrast CT scans using AI-based software, adversely affect survival outcomes in patients with colon cancer.PMID:37634640 | PMC:PMC10462901 | DOI:10.3348/kjr.2023.0109
Source: Korean J Radiol - August 27, 2023 Category: Radiology Authors: Minsung Kim Sang Min Lee Il Tae Son Taeyong Park Bo Young Oh Source Type: research
