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Total 361 results found since Jan 2013.

Awareness toward breast cancer and practice of breast self-examination among Iraqi female students at faculty of basic education
J Adv Pharm Technol Res. 2023 Jul-Sep;14(3):248-252. doi: 10.4103/japtr.japtr_281_23. Epub 2023 Jul 28.ABSTRACTThe most prevalent cancer and the one with the highest fatality rate is breast cancer, accounting for 27% of all malignancies in women and ranking one among all cancers in women. It appears that breast cancer affects both developed and developing nations. Hence, raising public awareness of breast malignancy prevention strategies is crucial in lowering the morbidity and mortality associated with the disease. The awareness and practices of female undergraduate students at Tikrit University regarding breast self-exam...
Source: Adv Data - September 11, 2023 Category: Epidemiology Authors: Nahed Ahmed Hassan Source Type: research

Phenotypically sorted highly and weakly migratory triple negative breast cancer cells exhibit migratory and metastatic commensalism
CONCLUSIONS: This study suggests that weakly migratory cells interact with highly migratory cells in a commensal fashion resulting in increased migration and metastasis. Together, these findings indicate that cancer cell subpopulation migration ability does not correlate with metastatic potential and that cooperation between highly migratory and weakly migratory subpopulations can enhance overall metastatic fitness.PMID:37649089 | PMC:PMC10468890 | DOI:10.1186/s13058-023-01696-3
Source: Cell Research - August 30, 2023 Category: Cytology Authors: Lauren A Hapach Wenjun Wang Samantha C Schwager Devika Pokhriyal Emily D Fabiano Cynthia A Reinhart-King Source Type: research

Sexual functioning, sexual enjoyment, and body image in Norwegian breast cancer survivors: a 12-year longitudinal follow-up study and comparison with the general female population
CONCLUSION: The impact of specific BC treatments on sexual functioning was modest; only mastectomy had a persistent negative influence. Nevertheless, all age groups in BC-Pop displayed significantly poorer sexual functioning than F-GenPop at both 12 months and up to 12 years after treatment.PMID:37534752 | DOI:10.1080/0284186X.2023.2238548
Source: Acta Oncologica - August 3, 2023 Category: Cancer & Oncology Authors: Ragnhild Emilie Åsberg Guro F Giske ødegård Sunil X Raj Jarle Karlsen Monica Engstr øm Øyvind Salvesen Marianne Nilsen Steinar Lundgren Randi Johansen Reidunsdatter Source Type: research

Revealing the concealed: A tribute to Donald L. Morton, MD
Clin Exp Metastasis. 2023 Jul 31. doi: 10.1007/s10585-023-10223-9. Online ahead of print.ABSTRACTDonald L. Morton, MD, epitomized one of America's dream scenarios: a person evolving from the humblest of origins to become an international celebrity in his profession, leading the world in the discipline of surgical oncology. His pioneering accomplishments in various roles have been well documented. Scientists, clinicians, students, and patients benefited from his contributions to the management of malignant diseases, particularly melanoma. His many attributes in pursuing the goal to cure malignant diseases are well known. Br...
Source: Clinical Breast Cancer - July 31, 2023 Category: Cancer & Oncology Authors: S David Nathanson Ian Wood Source Type: research

MiR-3653 blocks autophagy to inhibit epithelial-mesenchymal transition in breast cancer cells by targeting the autophagy-regulatory genes ATG12 and AMBRA1
CONCLUSIONS: Our findings suggested that miR-3653 inhibits the autophagy process by targeting ATG12 and AMBRA1, thereby inhibiting EMT, and provided a new idea and target for the metastasis of breast cancer.PMID:37464439 | DOI:10.1097/CM9.0000000000002569
Source: Chinese Medical Journal - July 18, 2023 Category: General Medicine Authors: Huachen Song Zitong Zhao Liying Ma Bailin Zhang Yongmei Song Source Type: research

HERPUD1, a Member of the Endoplasmic Reticulum Protein Quality Control Mechanism, may be a Good Target for Suppressing Tumorigenesis in Breast Cancer Cells
CONCLUSION: Present data suggest that HERPUD1 may be an effective target for biotechnological and pharmacological strategies to be developed to treat breast cancer.PMID:37417198 | DOI:10.4274/tjps.galenos.2022.71643
Source: Cancer Control - July 7, 2023 Category: Cancer & Oncology Authors: Yal çın Erzurumlu Ya ğmur Doğanlar Hatice K übra Doğan Deniz Çataklı Source Type: research

Genomic characteristics of triple negative apocrine carcinoma: a comparison to triple negative breast cancer
In this study, we evaluated the genomic characteristics of TNAC compared to TNBC with low Ki-67 (LK-TNBC). In the genetic analysis of 73 TNACs and 32 LK-TNBCs, the most frequently mutated driver gene in TNAC was TP53 (16/56, 28.6%), followed by PIK3CA (9/56, 16.1%), ZNF717 (8/56, 14.3%), and PIK3R1 (6/56, 10.71%). Mutational signature analysis showed enrichment of defective DNA mismatch repair (MMR)-related signatures (SBS6 and SBS21) and the SBS5 signature in TNAC, whereas an APOBEC activity-associated mutational signature (SBS13) was more prominent in LK-TNBC (Student's t test, p < 0.05). In intrinsic subtyping, 38.4%...
Source: Molecular Medicine - July 2, 2023 Category: Molecular Biology Authors: Ji-Yeon Kim Sabin Park Eun Yoon Cho Jeong Eon Lee Hae Hyun Jung Byung Joo Chae Seok Won Kim Seok Jin Nam Soo Youn Cho Yeon Hee Park Jin Seok Ahn Semin Lee Young-Hyuck Im Source Type: research

Building a Digital Immune System
Credit: Courtesy of Dr. Tomas Helikar. The power of computer code has been a longtime fascination for Tomas Helikar, Ph.D., a professor of biochemistry at the University of Nebraska-Lincoln (UNL). In college, when he learned he could use that power to help researchers better understand biology and improve human health, Dr. Helikar knew he’d found his ideal career. Since then, he’s built a successful team of scientists studying the ways we can use mathematical models in biomedical research, such as creating a digital replica of the immune system that could predict how a patient will react to infectious microorganisms ...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - June 28, 2023 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist Cells Tools and Techniques Bioinformatics Computational Biology Cool Tools/Techniques Modeling Profiles Source Type: blogs

Breast cancer diagnosis and prognosis using a high b-value non-Gaussian continuous-time random-walk model
CONCLUSION: Diffusion parameters derived from the CTRW model could effectively discriminate the malignancy of breast lesions. Meanwhile, the hormone receptor expression could be distinguished by combined diffusion parameters, and have the potential to reflect the prognosis.PMID:37344324 | DOI:10.1016/j.crad.2023.05.016
Source: Clinical Breast Cancer - June 21, 2023 Category: Cancer & Oncology Authors: H Feng H Liu Q Wang M Song T Yang L Zheng D Wu X Shao G Shi Source Type: research