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Cancer: Childhood Cancer

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Total 243 results found since Jan 2013.

How to Keep Alzheimer ’s From Bringing About the Zombie Apocalypse
I tried to kill my father for years. To be fair, I was following his wishes. He’d made it clear that when he no longer recognized me, when he could no longer talk, when the nurses started treating him like a toddler, he didn’t want to live any longer. My father was 58 years old when he was diagnosed with Alzheimer’s disease. He took the diagnosis with the self-deprecating humor he’d spent a lifetime cultivating, constantly cracking jokes about how he would one day turn into a zombie, a walking corpse. We had a good 10 years with him after the diagnosis. Eventually, his jokes came true. Seven years ...
Source: TIME: Science - November 20, 2019 Category: Science Authors: Jay Newton-Small Tags: Uncategorized Alzheimer's Disease Source Type: news

Overweight and obesity among the boys of primary public schools of Baish City in Jazan Province, Saudi Arabia: A cross-sectional study
Conclusions: Overweight and obesity was substantially prevalent among primary schoolboys with a significant rural–urban difference.
Source: Indian Journal of Public Health - December 17, 2019 Category: International Medicine & Public Health Authors: Mohammed Ibrahim Fakeeh Mohd Shanawaz Fahad Khan Azeez Ibrahim Ali Arar Source Type: research

NIH Slated for 7 percent Budget Cut
The President has proposed a $38.7 billion budget for the National Institutes of Health in fiscal year (FY) 2021. This translates to a $3 billion or 7 percent cut in the agency’s funding compared to FY 2020. The NIH budget request includes a $50 million initiative to use artificial intelligence (AI) to develop a better understanding of the causes of chronic diseases and to identify early treatments. This plan is in line with the Administration’s “Industries of the Future” effort, which supports using and developing AI across sectors. The budget would provide $50 million for the Childhood Cancer ...
Source: Public Policy Reports - February 18, 2020 Category: Biology Authors: AIBS Source Type: news

Cancers, Vol. 12, Pages 1285: Genome-Wide Association Meta-Analysis of Single-Nucleotide Polymorphisms and Symptomatic Venous Thromboembolism during Therapy for Acute Lymphoblastic Leukemia and Lymphoma in Caucasian Children
Conclusion: This represents the largest GWAS meta-analysis conducted to date associating SNPs to VTE in children and adolescents treated on childhood ALL protocols. Validation of these findings is needed and may then lead to patient stratification for VTE preventive interventions. As VTE hemostasis involves multiple pathways, a more powerful GWAS is needed to detect combination of variants associated with VTE.
Source: Cancers - May 18, 2020 Category: Cancer & Oncology Authors: Marion K. Mateos Morten Tulstrup Michael CJ Quinn Ruta Tuckuviene Glenn M. Marshall Ramneek Gupta Chelsea Mayoh Benjamin O. Wolthers Pasquale M. Barbaro Ellen Ruud Rosemary Sutton Pasi Huttunen Tamas Revesz Sonata S. Trakymiene Draga Barbaric Ulf Tedg år Tags: Article Source Type: research

Marijuana Use for Women: To Prescribe or Not to Prescribe.
Conclusions: Benefits and risks for both the patient and the offspring especially in the long term regarding marijuana use should be carefully weighed for each specific case. Standardized dosing and duration of treatment need to be determined. Recommendations should be made by physicians with expert training and after careful patient evaluation for fully informed patients, whose preference should be respected. Legislations should encourage more active basic, translational, and clinical studies. PMID: 32627638 [PubMed - as supplied by publisher]
Source: Substance Use and Misuse - July 8, 2020 Category: Addiction Tags: Subst Use Misuse Source Type: research

The State of Our Understanding of the Pathophysiology and Optimal Treatment of Depression: Glass Half Full or Half Empty?
Abstract Major depressive disorder is a remarkably common and often severe psychiatric disorder associated with high levels of morbidity and mortality. Patients with major depression are prone to several comorbid psychiatric conditions, including posttraumatic stress disorder, anxiety disorders, obsessive-compulsive disorder, and substance use disorders, and medical conditions, including cardiovascular disease, diabetes, stroke, cancer, which, coupled with the risk of suicide, result in a shortened life expectancy. The goal of this review is to provide an overview of our current understanding of major depression, ...
Source: The American Journal of Psychiatry - July 31, 2020 Category: Psychiatry Authors: Nemeroff CB Tags: Am J Psychiatry Source Type: research

Drugs against alpha-ketoglutarate may combat deadly childhood brain tumor
(NIH/National Institute of Neurological Disorders and Stroke) Every year, 150 to 300 children in the United States are diagnosed with diffuse intrinsic pontine gliomas (DIPGs), aggressive and lethal tumors that grow deep inside the brain, for which there are no cures. In a study funded by the National Institutes of Health, researchers showed that experimental drugs designed to lower the body's natural production of alpha-ketoglutarate extended the lives of mice harboring DIPG tumors by slowing the growth of the cancer cells.
Source: EurekAlert! - Cancer - August 18, 2020 Category: Cancer & Oncology Source Type: news

Parental, Perinatal, and Childhood Risk Factors for Development of Irritable Bowel Syndrome: A Systematic Review.
Conclusions: More effort is needed to identify what fetal and maternal factors are associated with low birth weight and IBS. A well-executed prospective birth cohort with a collection of bio-samples and functional data will provide a better understanding of how adversity and the interplay between genetics, epigenetics, and numerous risk factors affect the development of IBS. PMID: 32989183 [PubMed]
Source: Journal of Neurogastroenterology and Motility - September 30, 2020 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

An Agathokakological tale of ∆9 -THC: Exploration of Possible Biological Targets.
Abstract ∆ 9 -Tetrahydrocannabinol (∆9 -THC), the active phytocannabinoid in cannabis, is virtually an adjunct to the endogenous endocannabinoid signaling system. By interacting with G-protein-coupled receptors CB1 and CB2, ∆9 -THC affects peripheral and central circulation by lowering sympathetic activity, altering gene expression, cell proliferation, and differentiation, decreasing leukocyte migration, modulating neurotransmitter release thereby modulating cardiovascular functioning, tumorigenesis, immune responses, behavioral and locomotory activities respectively. ∆ 9 -THC is effective in suppressing c...
Source: Current Drug Targets - September 30, 2020 Category: Drugs & Pharmacology Authors: Mathew B, Harilal S, Musa A, Kumar R, Parambi DGT, Jose J, Uddin MS, Shah MA, Behl T, Unnikrishnan MK Tags: Curr Drug Targets Source Type: research

Economic growth as an underlying probable systemic driver for childhood obesity in South Africa: A Joinpoint regression and ecological analysis over 10 years
CONCLUSIONS: An increase in childhood and adolescent obesity over time was observed, while trend associations between obesity and EGIs exist.PMID:33944743 | DOI:10.7196/SAMJ.2021.v111i3.14669
Source: South African Medical Journal - May 4, 2021 Category: African Health Authors: P T Pisa N M Pisa P Chikandiwa A Chikandiwa Source Type: research