Filtered By:
Cancer: Bronchial Tumour

This page shows you your search results in order of date.

Order by Relevance | Date

Total 99 results found since Jan 2013.

S100A8/A9-RAGE pathway and chronic airway inflammation in smoke-induced lung carcinogenesis
ConclusionOur study suggests that the S100A8/A9-RAGE signal pathway is the mainstream of the inflammation-immune response induced in cancer progression in CSE-related smoke-induced lung carcinogenesis in vitro and in vivo. Further studies are needed to identify the therapeutic targets of cigarette smoke-induced inflammation and immunosuppression in the tumor microenvironment.
Source: Molecular and Cellular Toxicology - March 15, 2023 Category: Cytology Source Type: research

RPL11 promotes non-small cell lung cancer cell proliferation by regulating endoplasmic reticulum stress and cell autophagy
CONCLUSION: Taken together, RPL11 has a tumor-promoting role in NSCLC. It promotes the cell proliferation of NSCLC cells by regulating ERS and autophagy.PMID:36869281 | DOI:10.1186/s12860-023-00469-2
Source: Cancer Control - March 3, 2023 Category: Cancer & Oncology Authors: Jie Chen Changda Lei Huahua Zhang Xiaoyong Huang Yang Yang Junli Liu Yuna Jia Haiyan Shi Yunqing Zhang Jing Zhang Juan Du Source Type: research

Cigarette smoke condensate induces centrosome clustering in normal lung epithelial cells
ConclusionsHere we report a novel role of cyclin D2 in the regulation of centrosome clustering, which could allow the identification of tumors sensitive to cyclin D2 inhibitors. Our data reveal a pathway that can be targeted to inhibit centrosome clustering by interfering with the expression of cyclin D2-associated genes.
Source: Cancer Medicine - January 9, 2023 Category: Cancer & Oncology Authors: Jose Thaiparambil, Chandra S. Amara, Subrata Sen, Nagireddy Putluri, Randa El ‐Zein Tags: RESEARCH ARTICLE Source Type: research

Involvement of a AS3MT/c-Fos/p53 signaling axis in arsenic-induced tumor in human lung cells
In this study, we showed that AS3MT protein expression was higher in the arsenic-exposed population compared to the unexposed population. AS3MT was also overexpressed in human lung adenocarcinoma (A549) and human bronchial epithelial (16HBE) cells exposed to arsenic (A549: 20-60 μmol/L; 16HBE: 2-6 μmol/L) for 48 h. Furthermore, we investigated the effects of AS3MT on cell proliferation and apoptosis using siRNA. The downregulation of AS3MT inhibited the proliferation and promoted the apoptosis of cells. Mechanistically, AS3MT was found to specifically bind to c-Fos, thereby inhibiting the binding of c-Fos to c-Jun. Addit...
Source: Cancer Control - November 18, 2022 Category: Cancer & Oncology Authors: Mingjun Sun Huirong Cheng Tianle Yu Jingwen Tan Ming Li Qian Chen Yun Gu Chenglan Jiang Shuting Li Yuefeng He Weihua Wen Source Type: research

Toll-Like Receptor 2 Modulates Pulmonary Inflammation and TNF- α Release Mediated by Mycoplasma pneumoniae
ConclusionWe concluded that TLR2 regulates M. pneumoniae-mediated lung inflammation and TNF-α release through the TLR2-MyD88-NF-κB signaling pathway.
Source: Frontiers in cellular and infection microbiology - March 17, 2022 Category: Microbiology Source Type: research

The TL1A-DR3 Axis in Asthma: Membrane-Bound and Secreted TL1A Co-Determined the Development of Airway Remodeling
CONCLUSIONS: Our results confirm differential TL1A expression (including its secreted and non-secreted form) in asthma, which modulates remodeling. The shared mechanism of action by which nsTL1A and secreted TL1A exert their effects on asthma development might be mediated via the nuclear factor-κB pathway. The TL1A-DR3 axis presents a promising therapeutic target in asthma.PMID:35255540 | DOI:10.4168/aair.2022.14.2.233
Source: Allergy, Asthma and Immunology Research - March 7, 2022 Category: Allergy & Immunology Authors: Jintao Zhang Dong Zhang Yun Pan Xiaofei Liu Jiawei Xu Xinrui Qiao Wenjing Cui Liang Dong Source Type: research